Standard Herbal Extract

Artichoke Leaf Extract Safety Tips

Handling of Artichoke Leaf Extract should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Effect of Zeolite Nano-Materials and Artichoke (Cynara scolymus L.) Leaf Extract on Increase in Urinary Clearance of Systematically Absorbed Nicotine.
  Malekshah RE, Mahjub R, Rastgarpanah M, Ghorbani M, Partoazar AR, Mehr SE, Dehpour AR, Dorkoosh FA.Arzneimittelforschung. 2012 Dec;62(12):650-4. doi: 10.1055/s-0032-1330018. Epub 2012 Nov 29.
• 2. Artichoke induces genetic toxicity and decreases ethyl methanesulfonate-related DNA damage in Chinese hamster ovary cells.
  Jacociunas LV, de Andrade HH, Lehmann M, de Abreu BR, Ferraz Ade B, da Silva J, Dihl RR.J Med Food. 2012 Oct;15(10):873-8. doi: 10.1089/jmf.2012.0032. Epub 2012 Aug 14.
• 3. Beneficial effects of artichoke leaf extract supplementation on increasing HDL-cholesterol in subjects with primary mild hypercholesterolaemia: a double-blind, randomized, placebo-controlled trial.
  Rondanelli M, Giacosa A, Opizzi A, Faliva MA, Sala P, Perna S, Riva A, Morazzoni P, Bombardelli E.Int J Food Sci Nutr. 2012 Jun 29. [Epub ahead of print]
• 4. Artichoke extract lowered plasma cholesterol and increased fecal bile acids in Golden Syrian hamsters.
  Qiang Z, Lee SO, Ye Z, Wu X, Hendrich S.Phytother Res. 2012 Jul;26(7):1048-52. doi: 10.1002/ptr.3698. Epub 2011 Dec 20.
• 5. [Phytotherapy with a mixture of dry extracts with hepato-protective effects containing artichoke leaves in the management of functional dyspepsia symptoms].
  Sannia A.Minerva Gastroenterol Dietol. 2010 Jun;56(2):93-9. Italian.
• 6. Effects of artichoke leaf extract on acute gastric mucosal injury in rats.
  Ishida K, Kojima R, Tsuboi M, Tsuda Y, Ito M.Biol Pharm Bull. 2010;33(2):223-9.
• 7. Artichoke leaf extract for treating hypercholesterolaemia.
  Wider B, Pittler MH, Thompson-Coon J, Ernst E.Cochrane Database Syst Rev. 2009 Oct 7;(4):CD003335. doi: 10.1002/14651858.CD003335.pub2. Review.
• 8. Artichoke leaf extract reduces oxidative stress and lipoprotein dyshomeostasis in rats fed on high cholesterol diet.
  Küskü-Kiraz Z, Mehmetçik G, Dogru-Abbasoglu S, Uysal M.Phytother Res. 2010 Apr;24(4):565-70. doi: 10.1002/ptr.2985.
• 9. Effect of artichoke leaf extract on hepatic and cardiac oxidative stress in rats fed on high cholesterol diet.
  Küçükgergin C, Aydin AF, Ozdemirler-Erata G, Mehmetçik G, Koçak-Toker N, Uysal M.Biol Trace Elem Res. 2010 Jun;135(1-3):264-74. doi: 10.1007/s12011-009-8484-9. Epub 2009 Aug 4.
• 10. Artichoke leave extract for chronic hepatitis C – a pilot study.
  Huber R, Müller M, Naumann J, Schenk T, Lüdtke R.Phytomedicine. 2009 Sep;16(9):801-4. doi: 10.1016/j.phymed.2009.03.007. Epub 2009 May 8.
• 11. Effect of pretreatment with artichoke extract on carbon tetrachloride-induced liver injury and oxidative stress.
  Mehmetçik G, Ozdemirler G, Koçak-Toker N, Cevikba? U, Uysal M.Exp Toxicol Pathol. 2008 Sep;60(6):475-80. doi: 10.1016/j.etp.2008.04.014. Epub 2008 Jun 25.
• 12. The influence of supplementation with artichoke (Cynara scolymus L.) extract on selected redox parameters in rowers.
  Skarpanska-Stejnborn A, Pilaczynska-Szczesniak L, Basta P, Deskur-Smielcka E, Horoszkiewicz-Hassan M.Int J Sport Nutr Exerc Metab. 2008 Jun;18(3):313-27.
• 13. Artichoke leaf extract (Cynara scolymus) reduces plasma cholesterol in otherwise healthy hypercholesterolemic adults: a randomized, double blind placebo controlled trial.
  Bundy R, Walker AF, Middleton RW, Wallis C, Simpson HC.Phytomedicine. 2008 Sep;15(9):668-75. doi: 10.1016/j.phymed.2008.03.001.
• 14. Flavonoids of Cynara scolymus possess potent xanthinoxidase inhibitory activity in vitro but are devoid of hypouricemic effects in rats after oral application.
  Sarawek S, Feistel B, Pischel I, Butterweck V.Planta Med. 2008 Feb;74(3):221-7. doi: 10.1055/s-2008-1034316. Epub 2008 Feb 26.
• 15. Clinical uses of artichoke leaf extract.
  Joy JF, Haber SL.Am J Health Syst Pharm. 2007 Sep 15;64(18):1904, 1906-9. No abstract available.
• 16. Time-resolved spectral studies of blue-green fluorescence of artichoke (Cynara cardunculus L. Var. Scolymus) leaves: identification of chlorogenic acid as one of the major fluorophores and age-mediated changes.
  Morales F, Cartelat A, Alvarez-Fernández A, Moya I, Cerovic ZG.J Agric Food Chem. 2005 Dec 14;53(25):9668-78.
• 17. Bioavailability and pharmacokinetics of caffeoylquinic acids and flavonoids after oral administration of Artichoke leaf extracts in humans.
  Wittemer SM, Ploch M, Windeck T, Müller SC, Drewelow B, Derendorf H, Veit M.Phytomedicine. 2005 Jan;12(1-2):28-38.
• 18. Antifungal activity of Cynara scolymus L. extracts.
  Zhu XF, Zhang HX, Lo R.Fitoterapia. 2005 Jan;76(1):108-11.
• 19. Phenolic compounds from the leaf extract of artichoke (Cynara scolymus L.) and their antimicrobial activities.
  Zhu X, Zhang H, Lo R.J Agric Food Chem. 2004 Dec 1;52(24):7272-8.
• 20. Artichoke leaf extract reduces symptoms of irritable bowel syndrome and improves quality of life in otherwise healthy volunteers suffering from concomitant dyspepsia: a subset analysis.
  Bundy R, Walker AF, Middleton RW, Marakis G, Booth JC.J Altern Complement Med. 2004 Aug;10(4):667-9.

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