Botanical Ingredient

Astilbin Safety Tips

Handling of Astilbin should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Aqueous Solubility and Stability Enhancement of Astilbin through Complexation with Cyclodextrins.
  Zhang QF, Nie HC, Shangguang XC, Yin ZP, Zheng GD, Chen JG.J Agric Food Chem. 2012 Dec 17. [Epub ahead of print]
• 2. Structure selective complexation of cyclodextrins with five polyphenols investigated by capillary electrokinetic chromatography.
  Zhang QF, Cheung HY, Shangguan X, Zheng G.J Sep Sci. 2012 Dec;35(23):3347-53. doi: 10.1002/jssc.201200528.
• 3. [Comparative pharmacokinetics study of astilbin after oral administration of Yinxieling prescription or Smilacis Glabrae Rhizoma to rats].
  Wang Y, Zhao R, Lu C.Zhongguo Zhong Yao Za Zhi. 2012 Jun;37(12):1859-61. Chinese.
• 4. Nuciferine stimulates insulin secretion from beta cells-an in vitro comparison with glibenclamide.
  Nguyen KH, Ta TN, Pham TH, Nguyen QT, Pham HD, Mishra S, Nyomba BL.J Ethnopharmacol. 2012 Jul 13;142(2):488-95. doi: 10.1016/j.jep.2012.05.024. Epub 2012 May 23.
• 5. Astilbin inhibits proliferation of rat aortic smooth muscle cells induced by angiotensin II and down-regulates expression of protooncogene.
  Li P, Gao S, Jie W, Ao Q, Huang Y.J Huazhong Univ Sci Technolog Med Sci. 2012 Apr;32(2):181-5. doi: 10.1007/s11596-012-0032-8. Epub 2012 Apr 20.
• 6. Chemical constituents comparison between Rhizoma Smilacis Glabrae and Rhizoma Smilacis Chinae by HPLC-DAD-MS/MS.
  Zhang QF, Guo YX, Zheng G, Wang WJ.Nat Prod Res. 2012 Mar 8. [Epub ahead of print]
• 7. Development of HPLC fingerprint for species differentiation and quality assessment of Rhizoma Smilacis Glabrae.
  Zhang QF, Cheung HY, Zeng LB.J Nat Med. 2013 Jan;67(1):207-11. doi: 10.1007/s11418-012-0648-9. Epub 2012 Mar 2.
• 8. Optimized self-microemulsifying drug delivery systems (SMEDDS) for enhanced oral bioavailability of astilbin.
  Mezghrani O, Ke X, Bourkaib N, Xu BH.Pharmazie. 2011 Oct;66(10):754-60.
• 9. Determination of puerarin in rabbit aqueous humor by liquid chromatography tandem mass spectrometry using microdialysis sampling after topical administration of puerarin PAMAM dendrimer complex.
  Wang WY, Yao C, Shao YF, Mu HJ, Sun KX.J Pharm Biomed Anal. 2011 Dec 5;56(4):825-9. doi: 10.1016/j.jpba.2011.07.017. Epub 2011 Jul 23.
• 10. Astilbin attenuates hyperuricemia and ameliorates nephropathy in fructose-induced hyperuricemic rats.
  Chen L, Lan Z, Zhou Y, Li F, Zhang X, Zhang C, Yang Z, Li P.Planta Med. 2011 Nov;77(16):1769-73. doi: 10.1055/s-0030-1271135. Epub 2011 May 25.
• 11. Effects of genistein, apigenin, quercetin, rutin and astilbin on serum uric acid levels and xanthine oxidase activities in normal and hyperuricemic mice.
  Huang J, Wang S, Zhu M, Chen J, Zhu X.Food Chem Toxicol. 2011 Sep;49(9):1943-7. doi: 10.1016/j.fct.2011.04.029. Epub 2011 May 10.
• 12. Isolation and characterization of two flavonoids, engeletin and astilbin, from the leaves of Engelhardia roxburghiana and their potential anti-inflammatory properties.
  Huang H, Cheng Z, Shi H, Xin W, Wang TT, Yu LL.J Agric Food Chem. 2011 May 11;59(9):4562-9. doi: 10.1021/jf2002969. Epub 2011 Apr 19.
• 13. Herbal medicines and infectious diseases: characterization by LC-SPE-NMR of some medicinal plant extracts used against malaria.
  Xu YJ, Capistrano R 1st, Dhooghe L, Foubert K, Lemière F, Maregesi S, Baldé A, Apers S, Pieters L.Planta Med. 2011 Jul;77(11):1139-48. doi: 10.1055/s-0030-1270719. Epub 2011 Feb 15.
• 14. Estrogenic and anti-estrogenic compounds from the Thai medicinal plant, Smilax corbularia (Smilacaceae).
  Wungsintaweekul B, Umehara K, Miyase T, Noguchi H.Phytochemistry. 2011 Apr;72(6):495-502. doi: 10.1016/j.phytochem.2010.12.018.
• 15. Inhibition of peroxidase activity and scavenging of reactive oxygen species by astilbin isolated from Dimorphandra mollis (Fabaceae, Caesalpinioideae).
  Petacci F, Freitas SS, Brunetti IL, Khalil NM.Biol Res. 2010;43(1):63-74. doi: /S0716-97602010000100008. Epub 2010 May 7.
• 16. [Chemical constituents of rhizomes of Smilax ferox].
  Yang A, Guo X.Zhongguo Zhong Yao Za Zhi. 2010 Sep;35(17):2293-5. Chinese.
• 17. Astilbin suppresses acute heart allograft rejection by inhibiting maturation and function of dendritic cells in mice.
  Zou S, Shen X, Tang Y, Fu Z, Zheng Q, Wang Q.Transplant Proc. 2010 Nov;42(9):3798-802. doi: 10.1016/j.transproceed.2010.06.031.
• 18. Development of capillary electrophoresis fingerprint for quality control of rhizoma Smilacis Glabrae.
  Zhang QF, Cheung HY.Phytochem Anal. 2011 Jan-Feb;22(1):18-25. doi: 10.1002/pca.1245. Epub 2010 Sep 16.
• 19. [Effects of astilbin on the expression of TNF alpha and IL-10 in liver warm ischemia-reperfusion injury].
  Lin RK, Zhang CH, Mu N, Yao QY, Dong SL, Ai QB, Wang QX.Zhonghua Gan Zang Bing Za Zhi. 2010 Jun;18(6):463-6. doi: 10.3760/cma.j.issn.1007-3418.2010.06.016. Chinese.
• 20. [Chemical constituents from Sarcandra glabra].
  Wang C, Zhu L, Yang J, Li C, Zhang D.Zhongguo Zhong Yao Za Zhi. 2010 Mar;35(6):714-7. Chinese.

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