Botanical Ingredient

Betulin Safety Tips

Handling of Betulin should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Cytotoxic betulin-derived hydroxypropargylamines trigger apoptosis.
  Csuk R, Sczepek R, Siewert B, Nitsche C.Bioorg Med Chem. 2012 Nov 24. doi:pii: S0968-0896(12)00900-5.  10.1016/j.bmc.2012.11.016. [Epub ahead of print]
• 2. The Pentacyclic Triterpenoids in Herbal Medicines and Their Pharmacological Activities in Diabetes and Diabetic Complications.
  Alqahtani A, Hamid K, Kam A, Wong KH, Abdelhak Z, Razmovski-Naumovski V, Chan K, Li KM, Groundwater PW, Li GQ.Curr Med Chem. 2012 Dec 3. [Epub ahead of print]
• 3. Betulin complex in γ-cyclodextrin derivatives: properties and antineoplasic activities in vitro and in vivo tumor models.
  Soica C, Dehelean C, Danciu C, Wang HM, Wenz G, Ambrus R, Bojin F, Anghel M.Int J Mol Sci. 2012 Nov 15;13(11):14992-5011. doi: 10.3390/ijms131114992.
• 4. Study of the betulin enriched birch bark extract effects on human carcinoma cells and ear inflammation.
  Dehelean CA, Soica C, Lede?i I, Alua? M, Zupko I, G Lu?can A, Cinta-Pinzaru S, Munteanu M.Chem Cent J. 2012 Nov 19;6(1):137. doi: 10.1186/1752-153X-6-137.
• 5. Triterpenoid profile of flower and leaf cuticular waxes of heather Calluna vulgaris.
  Szakiel A, Ni?ynski B, P?czkowski C.Nat Prod Res. 2012 Nov 13. [Epub ahead of print]
• 6. Molecular docking analyses of Avicennia marinaderived phytochemicals against white spot syndrome virus (WSSV) envelope protein-VP28.
  Sahu SK, Kathiresan K, Singh R, Senthilraja P.Bioinformation. 2012;8(18):897-900. doi: 10.6026/97320630008897. Epub 2012 Sep 21.
• 7. Fast separation of triterpenoids by supercritical fluid chromatography/evaporative light scattering detector.
  Lesellier E, Destandau E, Grigoras C, Fougère L, Elfakir C.J Chromatogr A. 2012 Dec 14;1268:157-65. doi: 10.1016/j.chroma.2012.09.102. Epub 2012 Oct 22.
• 8. Effect of triterpene derivatives on the total hepatocyte count in the liver of rats with toxic hepatitis.
  Semenov DE, Zhukova NA, Bessergeneva EP, Sorokina IV, Baev DS, Glukhov BM, Nepomnyaschikh GI, Tolstikova TG.Bull Exp Biol Med. 2012 Oct;153(6):858-61. English, Russian.
• 9. Cytotoxic constituents from the stem bark of Diospyros cuneata Standl.
  Quintal-Novelo C, Moo-Puc RE, Chale-Dzul J, Cáceres-Farfán M, Mendez-Gonzalez M, Borges-Argáez R.Nat Prod Res. 2012 Oct 26. [Epub ahead of print]
• 10. A practical synthesis of betulonic acid using selective oxidation of betulin on aluminium solid support.
  Melnikova N, Burlova I, Kiseleva T, Klabukova I, Gulenova M, Kislitsin CA, Vasin V, Tanaseichuk B.Molecules. 2012 Oct 9;17(10):11849-63. doi: 10.3390/molecules171011849.
• 11. Enzymatic biotransformation of terpenes as bioactive agents.
  Sultana N, Saify ZS.J Enzyme Inhib Med Chem. 2012 Oct 9. [Epub ahead of print]
• 12. A novel one-step microbial transformation of betulin to betulinic acid catalysed by Cunninghamella blakesleeana.
  Feng Y, Li M, Liu J, Xu TY, Fang RS, Chen QH, He GQ.Food Chem. 2013 Jan 1;136(1):73-9. doi: 10.1016/j.foodchem.2012.07.088. Epub 2012 Jul 28.
• 13. Study of skin anti-ageing and anti-inflammatory effects of dihydroquercetin, natural triterpenoids, and their synthetic derivatives.
  Lee CW, Park NH, Kim JW, Um BH, Shpatov AV, Shults EE, Sorokina IV, Popov SA.Bioorg Khim. 2012 May-Jun;38(3):374-81.
• 14. X-ray diffraction and infrared spectroscopy of N,N-dimethylformamide and dimethyl sulfoxide solvatomorphs of betulonic acid.
  Boryczka S, Jastrzebska M, B?benek E, Kusz J, Zubko M, Kadela M, Michalik E.J Pharm Sci. 2012 Dec;101(12):4458-71. doi: 10.1002/jps.23321. Epub 2012 Sep 16.
• 15. Constituents of twig bark of pear cultivars (Pyrus species).
  Tomosaka H, Tamimoto H, Tsukagoshi Y, Suzuki Y, Ooka H, Ota M.Nat Prod Commun. 2012 Aug;7(8):987-8.
• 16. Betulin as an antitumor agent tested in vitro on A431, HeLa and MCF7, and as an angiogenic inhibitor in vivo in the CAM assay.
  Dehelean CA, Feflea S, Molnár J, Zupko I, Soica C.Nat Prod Commun. 2012 Aug;7(8):981-5.
• 17. Lignans and triterpenes from the root of Pseuderanthemum carruthersii var. atropurpureum.
  Vo TN, Nguyen PL, Tuong LT, Pratt LM, Vo PN, Nguyen KP, Nguyen NS.Chem Pharm Bull (Tokyo). 2012;60(9):1125-33.
• 18. One new pyrroline compound from Callistemon viminalis (Sol. Ex Gaertner) G.Don Ex Loudon.
  Gohar AA, Maatooq GT, Gadara SR, Aboelmaaty WS.Nat Prod Res. 2012 Sep 11. [Epub ahead of print]
• 19. In vitro schistosomicidal activity of some brazilian cerrado species and their isolated compounds.
  Cunha NL, Uchôa CJ, Cintra LS, de Souza HC, Peixoto JA, Silva CP, Magalhães LG, Gimenez VM, Groppo M, Rodrigues V, da Silva Filho AA, Andrade E Silva ML, Cunha WR, Pauletti PM, Januário AH.Evid Based Complement Alternat Med. 2012;2012:173614. doi: 10.1155/2012/173614. Epub 2012 Aug 8.
• 20. Extraction of betulin, trimyristin, eugenol, and carnosic acid using water-organic solvent mixtures.
  Lugemwa FN.Molecules. 2012 Aug 3;17(8):9274-82. doi: 10.3390/molecules17089274.

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