Botanical Ingredient

Betulinic Acid Safety Tips

Handling of Betulinic Acid should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Application of a liquid chromatography-electrospray mass spectrometry (LC/MS) method to the biodistribution and excretion studies of novel 5′-chloro-2, 3-didehydroindolo (2′, 3′: 2, 3) betulinic acid (DRF-4012) in tumour-bearing mice.
  Mishra G, Singh MK, Awasthi A, Singh AT, Jaggi M, Ahmad FJ.Xenobiotica. 2012 Dec 21. [Epub ahead of print]
• 2. Combined Treatment of Betulinic Acid, a PTP1B Inhibitor, with Orthosiphon stamineus Extract Decreases Body Weight in High-Fat-Fed Mice.
  Choi YJ, Park SY, Kim JY, Won KC, Kim BR, Son JK, Lee SH, Kim YW.J Med Food. 2012 Dec 20. [Epub ahead of print]
• 3. [Chemical constituents from the aerial roots of Ficus microcarpa].
  Jiang B, Han WL, Zhang QW, Zhang XQ, Ye WC.Zhong Yao Cai. 2012 Jun;35(6):904-8. Chinese.
• 4. A new norditerpenoid from Euonymus grandiflorus Wall.
  Li C, Li B, Ye J, Zhang W, Shen Y, Yin J.Nat Prod Res. 2012 Dec 12. [Epub ahead of print]
• 5. The Pentacyclic Triterpenoids in Herbal Medicines and Their Pharmacological Activities in Diabetes and Diabetic Complications.
  Alqahtani A, Hamid K, Kam A, Wong KH, Abdelhak Z, Razmovski-Naumovski V, Chan K, Li KM, Groundwater PW, Li GQ.Curr Med Chem. 2012 Dec 3. [Epub ahead of print]
• 6. Design, synthesis and biological evaluation of novel betulinic acid derivatives.
  Yang S, Liang N, Li H, Xue W, Hu D, Jin L, Zhao Q, Yang S.Chem Cent J. 2012 Nov 23;6(1):141. [Epub ahead of print]
• 7. Study of the betulin enriched birch bark extracts effects on human carcinoma cells and ear inflammation.
  Dehelean CA, Soica C, Lede?i I, Alua? M, Zupko I, G Lu?can A, Cinta-Pinzaru S, Munteanu M.Chem Cent J. 2012 Nov 19;6(1):137. doi: 10.1186/1752-153X-6-137.
• 8. Structural and Functional Insights into the HIV-1 Maturation Inhibitor Binding Pocket.
  Waki K, Durell SR, Soheilian F, Nagashima K, Butler SL, Freed EO.PLoS Pathog. 2012 Nov;8(11):e1002997. doi: 10.1371/journal.ppat.1002997. Epub 2012 Nov 8.
• 9. Molecular docking analyses of Avicennia marinaderived phytochemicals against white spot syndrome virus (WSSV) envelope protein-VP28.
  Sahu SK, Kathiresan K, Singh R, Senthilraja P.Bioinformation. 2012;8(18):897-900. doi: 10.6026/97320630008897. Epub 2012 Sep 21.
• 10. Fast separation of triterpenoids by supercritical fluid chromatography/evaporative light scattering detector.
  Lesellier E, Destandau E, Grigoras C, Fougère L, Elfakir C.J Chromatogr A. 2012 Dec 14;1268:157-65. doi: 10.1016/j.chroma.2012.09.102. Epub 2012 Oct 22.
• 11. New iridoid glycoside from Gratiola officinalis.
  Ali L, Rizvi TS, Ahmad M, Shaheen F.J Asian Nat Prod Res. 2012;14(12):1191-5. doi: 10.1080/10286020.2012.734299. Epub 2012 Nov 8.
• 12. Antidepressant-like effects of fractions, essential oil, carnosol, and betulinic acid isolated from Rosmarinus officinalis L.
  Machado DG, Cunha MP, Neis VB, Balen GO, Colla A, Bettio LE, Oliveira A, Pazini FL, Dalmarco JB, Simionatto EL, Pizzolatti MG, Rodrigues AL.Food Chem. 2013 Jan 15;136(2):999-1005. doi: 10.1016/j.foodchem.2012.09.028. Epub 2012 Sep 16.
• 13. A simple GC-MS method for the screening of betulinic, corosolic, maslinic, oleanolic and ursolic acid contents in commercial botanicals used as food supplement ingredients.
  Caligiani A, Malavasi G, Palla G, Marseglia A, Tognolini M, Bruni R.Food Chem. 2013 Jan 15;136(2):735-41. doi: 10.1016/j.foodchem.2012.08.011. Epub 2012 Aug 16.
• 14. Betulinic acid inhibits superoxide anion-mediated impairment of endothelium-dependent relaxation in rat aortas.
  Qian LB, Fu JY, Cai X, Xia ML.Indian J Pharmacol. 2012 Sep;44(5):588-92. doi: 10.4103/0253-7613.100382.
• 15. Synthesis and antiplasmodial activity of betulinic acid and ursolic acid analogues.
  Innocente AM, Silva GN, Cruz LN, Moraes MS, Nakabashi M, Sonnet P, Gosmann G, Garcia CR, Gnoatto SC.Molecules. 2012 Oct 12;17(10):12003-14. doi: 10.3390/molecules171012003.
• 16. Synthesis and Biological Activity of 28-Amide Derivatives of 23-Hydroxy Betulinic Acid as Antitumor Agent Candidates.
  Bi Y, Xu J, Sun F, Wu X, Ye W, Sun Y, Huang W.Med Chem. 2012 Oct 17. [Epub ahead of print]
• 17. Betulinic acid inhibits autophagic flux and induces apoptosis in human multiple myeloma cells in vitro.
  Yang LJ, Chen Y, He J, Yi S, Wen L, Zhao J, Zhang BP, Cui GH.Acta Pharmacol Sin. 2012 Dec;33(12):1542-8. doi: 10.1038/aps.2012.102. Epub 2012 Oct 15.
• 18. Betulinic Acid inhibits growth of cultured vascular smooth muscle cells in vitro by inducing g(1) arrest and apoptosis.
  Vadivelu RK, Yeap SK, Ali AM, Hamid M, Alitheen NB.Evid Based Complement Alternat Med. 2012;2012:251362. doi: 10.1155/2012/251362. Epub 2012 Sep 27.
• 19. BBA, a Derivative of 23-Hydroxybetulinic Acid, Potently Reverses ABCB1-Mediated Drug Resistance in Vitro and in Vivo.
  Zhang DM, Shu C, Chen JJ, Sodani K, Wang J, Bhatnagar J, Lan P, Ruan ZX, Xiao ZJ, Ambudkar SV, Chen WM, Chen ZS, Ye WC.Mol Pharm. 2012 Nov 5;9(11):3147-59. doi: 10.1021/mp300249s. Epub 2012 Oct 22.
• 20. [Chemical constituents contained in Macropanax rosthornii].
  Luo Y, Liu H, Yin X, Ye X, Kang L.Zhongguo Zhong Yao Za Zhi. 2012 Jul;37(13):1977-80. Chinese.

Details