Standard Herbal Extract

Bilberry Extract Safety Tips

Handling of Bilberry Extract should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Stability of anthocyanin-rich w/o/w-emulsions designed for intestinal release in gastrointestinal environment.
  Frank K, Walz E, Gräf V, Greiner R, Köhler K, Schuchmann HP.J Food Sci. 2012 Dec;77(12):N50-7. doi: 10.1111/j.1750-3841.2012.02982.x.
• 2. Anthocyanins, but not Anthocyanidins, from Bilberry (Vaccinium myrtillus L.) Alleviate Pruritus via Inhibition of Mast Cell Degranulation.
  Yamaura K, Ishiwatari M, Yamamoto M, Shimada M, Bi Y, Ueno K.J Food Sci. 2012 Dec;77(12):H262-7. doi: 10.1111/j.1750-3841.2012.02974.x. Epub 2012 Nov 19.
• 3. Effect of Fermented Bilberry Extracts on Visual Outcomes in Eyes with Myopia: A Prospective, Randomized, Placebo-Controlled Study.
  Kamiya K, Kobashi H, Fujiwara K, Ando W, Shimizu K.J Ocul Pharmacol Ther. 2012 Oct 31. [Epub ahead of print]
• 4. Bog bilberry anthocyanin extract improves motor functional recovery by multifaceted effects in spinal cord injury.
  Wang J, Ma C, Rong W, Jing H, Hu X, Liu X, Jiang L, Wei F, Liu Z.Neurochem Res. 2012 Dec;37(12):2814-25. doi: 10.1007/s11064-012-0883-1. Epub 2012 Sep 22.
• 5. Modulation of inflammatory gene expression by a bilberry ( Vaccinium myrtillus L.) extract and single anthocyanins considering their limited stability under cell culture conditions.
  Triebel S, Trieu HL, Richling E.J Agric Food Chem. 2012 Sep 12;60(36):8902-10. doi: 10.1021/jf3028842. Epub 2012 Aug 27.
• 6. Ginkgo biloba extract and bilberry anthocyanins improve visual function in patients with normal tension glaucoma.
  Shim SH, Kim JM, Choi CY, Kim CY, Park KH.J Med Food. 2012 Sep;15(9):818-23. doi: 10.1089/jmf.2012.2241. Epub 2012 Aug 7.
• 7. Vaccinium myrtillus ameliorates unpredictable chronic mild stress induced depression: possible involvement of nitric oxide pathway.
  Kumar B, Arora V, Kuhad A, Chopra K.Phytother Res. 2012 Apr;26(4):488-97. doi: 10.1002/ptr.3584. Epub 2011 Aug 26.
• 8. Preparation and comparative release characteristics of three anthocyanin encapsulation systems.
  Oidtmann J, Schantz M, Mäder K, Baum M, Berg S, Betz M, Kulozik U, Leick S, Rehage H, Schwarz K, Richling E.J Agric Food Chem. 2012 Jan 25;60(3):844-51. doi: 10.1021/jf2047515. Epub 2012 Jan 13.
• 9. Effects of dietary supplementation with a combination of fish oil, bilberry extract, and lutein on subjective symptoms of asthenopia in humans.
  Kawabata F, Tsuji T.Biomed Res. 2011 Dec;32(6):387-93.
• 10. Sealing liquid-filled pectinate capsules with a shellac coating.
  Henning S, Leick S, Kott M, Rehage H, Suter D.J Microencapsul. 2012;29(2):147-55. doi: 10.3109/02652048.2011.635220. Epub 2011 Nov 30.
• 11. Identification and characterization of low molecular weight polyphenols in berry leaf extracts by HPLC-DAD and LC-ESI/MS.
  Oszmianski J, Wojdy?o A, Gorzelany J, Kapusta I.J Agric Food Chem. 2011 Dec 28;59(24):12830-5. doi: 10.1021/jf203052j. Epub 2011 Nov 29.
• 12. Anthocyanins from bilberry (Vaccinium myrtillus L.) alleviate pruritus in a mouse model of chronic allergic contact dermatitis.
  Yamaura K, Shimada M, Ueno K.Pharmacognosy Res. 2011 Jul;3(3):173-7. doi: 10.4103/0974-8490.85002.
• 13. Attenuated total reflection infrared (ATR-IR) spectroscopy of a water-in-oil emulsion.
  Kiefer J, Frank K, Schuchmann HP.Appl Spectrosc. 2011 Sep;65(9):1024-8. doi: 10.1366/11-06323.
• 14. Vision preservation during retinal inflammation by anthocyanin-rich bilberry extract: cellular and molecular mechanism.
  Miyake S, Takahashi N, Sasaki M, Kobayashi S, Tsubota K, Ozawa Y.Lab Invest. 2012 Jan;92(1):102-9. doi: 10.1038/labinvest.2011.132. Epub 2011 Sep 5.
• 15. Protective effect of bilberry (Vaccinium myrtillus) against doxorubicin-induced oxidative cardiotoxicity in rats.
  Ashour OM, Elberry AA, Alahdal A, Al Mohamadi AM, Nagy AA, Abdel-Naim AB, Abdel-Sattar EA, Mohamadin AM.Med Sci Monit. 2011 Apr;17(4):BR110-5.
• 16. [Determination of the qualitative and quantitative composition of antocyan pigments as components of dietary supplements and drugs for vision].
  Gottikh MB, Tashlitski? VN.Vestn Oftalmol. 2010 Sep-Oct;126(5):34-7. Russian.
• 17. Different berries and berry fractions have various but slightly positive effects on the associated variables of metabolic diseases on overweight and obese women.
  Lehtonen HM, Suomela JP, Tahvonen R, Yang B, Venojärvi M, Viikari J, Kallio H.Eur J Clin Nutr. 2011 Mar;65(3):394-401. doi: 10.1038/ejcn.2010.268. Epub 2011 Jan 12.
• 18. Nutrigenomic analysis of the protective effects of bilberry anthocyanin-rich extract in apo E-deficient mice.
  Mauray A, Felgines C, Morand C, Mazur A, Scalbert A, Milenkovic D.Genes Nutr. 2010 Dec;5(4):343-53. doi: 10.1007/s12263-010-0171-0. Epub 2010 Mar 1.
• 19. Effects of standardized bilberry fruit extract (Mirtoselect®) on resolution of CCl4-induced liver fibrosis in mice.
  Domitrovi? R, Jakovac H.Food Chem Toxicol. 2011 Apr;49(4):848-54. doi: 10.1016/j.fct.2010.12.006. Epub 2010 Dec 14.
• 20. Inhibition of adhesion of Neisseria meningitidis to human epithelial cells by berry juice polyphenolic fractions.
  Toivanen M, Huttunen S, Lapinjoki S, Tikkanen-Kaukanen C.Phytother Res. 2011 Jun;25(6):828-32. doi: 10.1002/ptr.3349. Epub 2010 Nov 17.