Botanical Ingredient

Biochanin A Safety Tips

Handling of Biochanin A should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Neuroprotective Effects of Biochanin A Against Glutamate-Induced Cytotoxicity in PC12 Cells Via Apoptosis Inhibition.
  Tan JW, Tham CL, Israf DA, Lee SH, Kim MK.Neurochem Res. 2012 Dec 6. [Epub ahead of print]
• 2. A modified QuEChERS method as sample treatment before the determination of isoflavones in foods by ultra-performance liquid chromatography-triple quadrupole mass spectrometry.
  Delgado-Zamarreño MM, Pérez-Martín L, Bustamante-Rangel M, Carabias-Martínez R.Talanta. 2012 Oct 15;100:320-8. doi: 10.1016/j.talanta.2012.07.070. Epub 2012 Aug 16.
• 3. Differential antiviral and anti-inflammatory mechanisms of the flavonoids biochanin A and baicalein in H5N1 influenza A virus-infected cells.
  Sithisarn P, Michaelis M, Schubert-Zsilavecz M, Cinatl J Jr.Antiviral Res. 2012 Oct 23;97(1):41-48. doi: 10.1016/j.antiviral.2012.10.004. [Epub ahead of print]
• 4. Phytotoxic effect, uptake, and transformation of biochanin in selected weed species.
  Shajib MT, Pedersen HA, Mortensen AG, Kudsk P, Fomsgaard IS.J Agric Food Chem. 2012 Oct 31;60(43):10715-22. doi: 10.1021/jf3023589. Epub 2012 Oct 18.
• 5. Distribution of isoflavones and coumestrol in neglected tropical and subtropical legumes.
  Leuner O, Havlik J, Hummelova J, Prokudina E, Novy P, Kokoska L.J Sci Food Agric. 2012 Aug 28. doi: 10.1002/jsfa.5835. [Epub ahead of print]
• 6. A Review of the Taxonomy, Ethnobotany, Chemistry and Pharmacology of Oroxylum indicum Vent.
  Harminder, Singh V, Chaudhary AK.Indian J Pharm Sci. 2011 Sep;73(5):483-90. doi: 10.4103/0250-474X.98981.
• 7. The protective effect of rutin against ischemia/reperfusion-associated hemodynamic alteration through antioxidant activity.
  Bhandary B, Piao CS, Kim DS, Lee GH, Chae SW, Kim HR, Chae HJ.Arch Pharm Res. 2012 Jun;35(6):1091-7. doi: 10.1007/s12272-012-0617-6. Epub 2012 Jun 30.
• 8. A standardized phytopreparation from an Indian medicinal plant (Dalbergia sissoo) has antiresorptive and bone-forming effects on a postmenopausal osteoporosis model of rat.
  Khedgikar V, Gautam J, Kushwaha P, Kumar A, Nagar GK, Dixit P, Chillara R, Voruganti S, Singh SP, Uddin W, Jain GK, Singh D, Maurya R, Chattopadhyay N, Trivedi R.Menopause. 2012 Dec;19(12):1336-46. doi: 10.1097/gme.0b013e318256b6ae.
• 9. A standardized phytopreparation from an Indian medicinal plant (Dalbergia sissoo) has antiresorptive and bone-forming effects on a postmenopausal osteoporosis model of rat.
  Khedgikar V, Gautam J, Kushwaha P, Kumar A, Nagar GK, Dixit P, Chillara R, Voruganti S, Singh SP, Uddin W, Jain GK, Singh D, Maurya R, Chattopadhyay N, Trivedi R.Menopause. 2012 Jul 23. [Epub ahead of print]
• 10. Effects of feeding dairy cows different legume-grass silages on milk phytoestrogen concentration.
  Höjer A, Adler S, Purup S, Hansen-Møller J, Martinsson K, Steinshamn H, Gustavsson AM.J Dairy Sci. 2012 Aug;95(8):4526-40. doi: 10.3168/jds.2011-5226.
• 11. Germination dramatically increases isoflavonoid content and diversity in chickpea (Cicer arietinum L.) seeds.
  Wu Z, Song L, Feng S, Liu Y, He G, Yioe Y, Liu SQ, Huang D.J Agric Food Chem. 2012 Sep 5;60(35):8606-15. doi: 10.1021/jf3021514. Epub 2012 Aug 15.
• 12. LC-MS/MS method for the detection of common laxatives.
  Middleberg RA, Homan J.Methods Mol Biol. 2012;902:157-66. doi: 10.1007/978-1-61779-934-1_14.
• 13. Aquatic photochemistry of isoflavone phytoestrogens: degradation kinetics and pathways.
  Felcyn JR, Davis JC, Tran LH, Berude JC, Latch DE.Environ Sci Technol. 2012 Jun 19;46(12):6698-704. doi: 10.1021/es301205a. Epub 2012 Jun 6.
• 14. [Interaction between three isoflavones and different isomers of human serum albumin].
  Ma J, Liu Y, Xie MX.Guang Pu Xue Yu Guang Pu Fen Xi. 2012 Jan;32(1):1-6. Chinese.
• 15. Ester and carbamate ester derivatives of Biochanin A: synthesis and in vitro evaluation of estrogenic and antiproliferative activities.
  Fokialakis N, Alexi X, Aligiannis N, Siriani D, Meligova AK, Pratsinis H, Mitakou S, Alexis MN.Bioorg Med Chem. 2012 May 1;20(9):2962-70. doi: 10.1016/j.bmc.2012.03.012. Epub 2012 Mar 10.
• 16. Effects of sodium metavanadate and germination on the sprouting of chickpeas and its content of vanadium, formononetin and biochanin A in the sprouts.
  Zhang L, Mao X, Xia Z.J Diet Suppl. 2012 Mar;9(1):34-44. doi: 10.3109/19390211.2011.639858. Epub 2012 Jan 5.
• 17. Pressurized liquid extraction as a sample preparation method for the analysis of isoflavones in pulses.
  Delgado-Zamarreño MM, Pérez-Martín L, Bustamante-Rangel M, Carabias-Martínez R.Anal Bioanal Chem. 2012 Aug;404(2):361-6. doi: 10.1007/s00216-012-5912-z. Epub 2012 Mar 18.
• 18. [Identification of major components of traditional Chinese medicine Naodesheng tablet by HPLC-DAD-MS(n)].
  Chen HZ, Li YF, Zhong JH, Fan XH.Zhejiang Da Xue Xue Bao Yi Xue Ban. 2012 Jan;41(1):32-42. Chinese.
• 19. Double-edged sword effect of biochanin to inhibit nuclear factor kappaB: suppression of serine/threonine and tyrosine kinases.
  Manna SK.Biochem Pharmacol. 2012 May 15;83(10):1383-92. doi: 10.1016/j.bcp.2012.02.011. Epub 2012 Feb 22.
• 20. The pollen extract Femal–a nonestrogenic alternative to hormone therapy in women with menopausal symptoms.
  Hellström AC, Muntzing J.Menopause. 2012 Jul;19(7):825-9. doi: 10.1097/gme.0b013e31824017bc.

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