Standard Herbal Extract

Bitter Melon Extract Safety Tips

Handling of Bitter Melon Extract should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Histomorphological Alterations in the Prostate Gland and Epithelium of Seminiferous Tubule of Sprague-Dawley Rats Treated with Methanolic Extract of Momordica charantia Seeds.
  Boetse YO, Ikechukwu DF, Olugbenga OA, Ayodele OA, Caramel NC.Iran J Med Sci. 2011 Dec;36(4):266-72.
• 2. Momordica charantia Extract Induces Apoptosis in Human Cancer Cells through Caspase- and Mitochondria-Dependent Pathways.
  Li CJ, Tsang SF, Tsai CH, Tsai HY, Chyuan JH, Hsu HY.Evid Based Complement Alternat Med. 2012;2012:261971. doi: 10.1155/2012/261971. Epub 2012 Oct 4.
• 3. Wild bitter melon (Momordica charantia Linn. var. abbreviata Ser.) extract and its bioactive components suppress Propionibacterium acnes-induced inflammation.
  Hsu C, Tsai TH, Li YY, Wu WH, Huang CJ, Tsai PJ.Food Chem. 2012 Dec 1;135(3):976-84. doi: 10.1016/j.foodchem.2012.05.045. Epub 2012 May 22.
• 4. The beneficial effects of Momordica charantia (bitter gourd) on wound healing of rabbit skin.
  Pi?kin A, Altunkaynak BZ, Tümentemur G, Kaplan S, Yaz?c? OB, Hökelek M.J Dermatolog Treat. 2012 Sep 21. [Epub ahead of print]
• 5. Glycosidic inhibitors of melanogenesis from leaves of Momordica charantia.
  Kikuchi T, Zhang J, Huang Y, Watanabe K, Ishii K, Yamamoto A, Fukatsu M, Tanaka R, Akihisa T.Chem Biodivers. 2012 Jul;9(7):1221-30. doi: 10.1002/cbdv.201100350.
• 6. In vitro modulation of oxidative burst via release of reactive oxygen species from immune cells by extracts of selected tropical medicinal herbs and food plants.
  Mahomoodally F, Mesaik A, Choudhary MI, Subratty AH, Gurib-Fakim A.Asian Pac J Trop Med. 2012 Jun;5(6):440-7. doi: 10.1016/S1995-7645(12)60075-3.
• 7. Mechanisms underlying decreased hepatic triacylglycerol and cholesterol by dietary bitter melon extract in the rat.
  Senanayake GV, Fukuda N, Nshizono S, Wang YM, Nagao K, Yanagita T, Iwamoto M, Ohta H.Lipids. 2012 May;47(5):495-503. doi: 10.1007/s11745-012-3667-0. Epub 2012 Mar 29.
• 8. Antimalarial activities of medicinal plants traditionally used in the villages of Dharmapuri regions of South India.
  Kamaraj C, Kaushik NK, Rahuman AA, Mohanakrishnan D, Bagavan A, Elango G, Zahir AA, Santhoshkumar T, Marimuthu S, Jayaseelan C, Kirthi AV, Rajakumar G, Velayutham K, Sahal D.J Ethnopharmacol. 2012 Jun 14;141(3):796-802. doi: 10.1016/j.jep.2012.03.003. Epub 2012 Mar 13.
• 9. Cucurbitane triterpenoids from the leaves of Momordica charantia, and their cancer chemopreventive effects and cytotoxicities.
  Zhang J, Huang Y, Kikuchi T, Tokuda H, Suzuki N, Inafuku K, Miura M, Motohashi S, Suzuki T, Akihisa T.Chem Biodivers. 2012 Feb;9(2):428-40. doi: 10.1002/cbdv.201100142.
• 10. Kuguacin J, a triterpeniod from Momordica charantia leaf, modulates the progression of androgen-independent human prostate cancer cell line, PC3.
  Pitchakarn P, Suzuki S, Ogawa K, Pompimon W, Takahashi S, Asamoto M, Limtrakul P, Shirai T.Food Chem Toxicol. 2012 Mar;50(3-4):840-7. doi: 10.1016/j.fct.2012.01.009. Epub 2012 Jan 15.
• 11. Inhibition of nuclear transcription factor-κB and activation of peroxisome proliferator-activated receptors in HepG2 cells by cucurbitane-type triterpene glycosides from Momordica charantia.
  Nhiem NX, Yen PH, Ngan NT, Quang TH, Kiem PV, Minh CV, Tai BH, Cuong NX, Song SB, Kim YH.J Med Food. 2012 Apr;15(4):369-77. doi: 10.1089/jmf.2011.1766. Epub 2012 Jan 16.
• 12. Screening of anti-dengue activity in methanolic extracts of medicinal plants.
  Tang LI, Ling AP, Koh RY, Chye SM, Voon KG.BMC Complement Altern Med. 2012 Jan 13;12:3. doi: 10.1186/1472-6882-12-3.
• 13. Trypanocide, cytotoxic, and antifungal activities of Momordica charantia.
  Santos KK, Matias EF, Sobral-Souza CE, Tintino SR, Morais-Braga MF, Guedes GM, Santos FA, Sousa AC, Rolón M, Vega C, de Arias AR, Costa JG, Menezes IR, Coutinho HD.Pharm Biol. 2012 Feb;50(2):162-6. doi: 10.3109/13880209.2011.581672.
• 14. Bitter melon (Momordica charantia) extract suppresses adrenocortical cancer cell proliferation through modulation of the apoptotic pathway, steroidogenesis, and insulin-like growth factor type 1 receptor/RAC-α serine/threonine-protein kinase signaling.
  Brennan VC, Wang CM, Yang WH.J Med Food. 2012 Apr;15(4):325-34. doi: 10.1089/jmf.2011.0158. Epub 2011 Dec 22.
• 15. Saponins from the traditional medicinal plant Momordica charantia stimulate insulin secretion in vitro.
  Keller AC, Ma J, Kavalier A, He K, Brillantes AM, Kennelly EJ.Phytomedicine. 2011 Dec 15;19(1):32-7. doi: 10.1016/j.phymed.2011.06.019. Epub 2011 Nov 30.
• 16. Pharmaceutical and biopharmaceutical evaluation of extracts from different plant parts of indigenous origin for their hypoglycemic responses in rabbits.
  Akhtar N, Khan BA, Majid A, Khan HM, Mahmood T, Gulfishan, Saeed T.Acta Pol Pharm. 2011 Nov-Dec;68(6):919-25.
• 17. Momordica charantia extract, a herbal remedy for type 2 diabetes, contains a specific 11β-hydroxysteroid dehydrogenase type 1 inhibitor.
  Blum A, Loerz C, Martin HJ, Staab-Weijnitz CA, Maser E.J Steroid Biochem Mol Biol. 2012 Jan;128(1-2):51-5. doi: 10.1016/j.jsbmb.2011.09.003. Epub 2011 Oct 1.
• 18. Effect of methanolic seed extract of Momordica charantia on body weight and serum cholesterol level of male Sprague-Dawley rats.
  Yama OE, Osinubi AA, Noronha CC, Okanlawon AO.Nig Q J Hosp Med. 2010 Oct-Dec;20(4):209-13.
• 19. Bitter melon extract impairs prostate cancer cell-cycle progression and delays prostatic intraepithelial neoplasia in TRAMP model.
  Ru P, Steele R, Nerurkar PV, Phillips N, Ray RB.Cancer Prev Res (Phila). 2011 Dec;4(12):2122-30. doi: 10.1158/1940-6207.CAPR-11-0376. Epub 2011 Sep 12.
• 20. Influence of Momordica charantia on oxidative stress-induced perturbations in brain monoamines and plasma corticosterone in albino rats.
  Kavitha N, Babu SM, Rao ME.Indian J Pharmacol. 2011 Jul;43(4):424-8. doi: 10.4103/0253-7613.83114.

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