Standard Herbal Extract

Black Cohosh Extract Safety Tips

Handling of Black Cohosh Extract should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Estrogen receptor mediated effects of Cimicifuga extracts on human breast cancer cells.
  Park J, Shim M, Rhyu MR, Lee Y.Pharmazie. 2012 Nov;67(11):947-50.
• 2. Discovery of a novel pharmacological and structural class of gamma secretase modulators derived from the extract of Actaea racemosa.
  Findeis MA, Schroeder F, McKee TD, Yager D, Fraering PC, Creaser SP, Austin WF, Clardy J, Wang R, Selkoe D, Eckman CB.ACS Chem Neurosci. 2012 Nov 21;3(11):941-51. doi: 10.1021/cn3000857. Epub 2012 Aug 28.
• 3. Antidepressant-like effects of the extract from Cimicifuga foetida L.
  Ye L, Hu Z, Du G, Zhang J, Dong Q, Fu F, Tian J.J Ethnopharmacol. 2012 Dec 18;144(3):683-91. doi: 10.1016/j.jep.2012.10.013. Epub 2012 Oct 13.
• 4. Cytotoxic caffeic acid derivatives from the rhizomes of Cimicifuga heracleifolia.
  Yim SH, Kim HJ, Park SH, Kim J, Williams DR, Jung DW, Lee IS.Arch Pharm Res. 2012 Sep;35(9):1559-65. doi: 10.1007/s12272-012-0906-0. Epub 2012 Oct 9.
• 5. Oral administration of Cimicifuga racemosa extract attenuates psychological and physiological stress responses.
  Nadaoka I, Yasue M, Kitagawa Y, Koga Y.Biomed Res. 2012 Jun;33(3):145-52.
• 6. Pharmacokinetics and bioavailability of cimicifugosides after oral administration of Cimicifuga foetida L. extract to rats.
  Gai YY, Liu WH, Sha CJ, Wang YL, Sun YT, Li XJ, Paul Fawcett J, Gu JK.J Ethnopharmacol. 2012 Aug 30;143(1):249-55. doi: 10.1016/j.jep.2012.06.031. Epub 2012 Jul 3.
• 7. Osteoprotective effects of Cimicifuga racemosa and its triterpene-saponins are responsible for reduction of bone marrow fat.
  Seidlova-Wuttke D, Stecher G, Kammann M, Haunschild J, Eder N, Stahnke V, Wessels J, Wuttke W.Phytomedicine. 2012 Jul 15;19(10):855-60. doi: 10.1016/j.phymed.2012.05.002. Epub 2012 Jun 26.
• 8. Alternative methods for the treatment of post-menopausal troubles.
  Aidelsburger P, Schauer S, Grabein K, Wasem J.GMS Health Technol Assess. 2012;8:Doc03. doi: 10.3205/hta000101. Epub 2012 May 7.
• 9. An ethanolic extract of black cohosh causes hematological changes but not estrogenic effects in female rodents.
  Mercado-Feliciano M, Cora MC, Witt KL, Granville CA, Hejtmancik MR, Fomby L, Knostman KA, Ryan MJ, Newbold R, Smith C, Foster PM, Vallant MK, Stout MD.Toxicol Appl Pharmacol. 2012 Sep 1;263(2):138-47. doi: 10.1016/j.taap.2012.05.022. Epub 2012 Jun 9.
• 10. Cimicifuga racemosa impairs fatty acid β-oxidation and induces oxidative stress in livers of ovariectomized rats with renovascular hypertension.
  Campos LB, Gilglioni EH, Garcia RF, Brito Mdo N, Natali MR, Ishii-Iwamoto EL, Salgueiro-Pagadigorria CL.Free Radic Biol Med. 2012 Aug 15;53(4):680-9. doi: 10.1016/j.freeradbiomed.2012.05.043. Epub 2012 Jun 7.
• 11. Effects of black cohosh and estrogen on the hypothalamic nuclei of ovariectomized rats at different temperatures.
  Hui Z, Xiaoyan M, Mukun Y, Ke W, Liyuan Y, Sainan Z, Jing J, Lihua Q, Wenpei B.J Ethnopharmacol. 2012 Aug 1;142(3):769-75. doi: 10.1016/j.jep.2012.05.059. Epub 2012 Jun 7.
• 12. Cimicifuga racemosa and its triterpene-saponins prevent the Metabolic Syndrome and deterioration of cartilage in the knee joint of ovariectomized rats by similar mechanisms.
  Seidlova-Wuttke D, Eder N, Stahnke V, Kammann M, Stecher G, Haunschild J, Wessels JT, Wuttke W.Phytomedicine. 2012 Jun 15;19(8-9):846-53. doi: 10.1016/j.phymed.2012.03.001. Epub 2012 May 17.
• 13. Oral administration of Cimicifuga racemosa extract affects immobilization stress-induced changes in murine cerebral monoamine metabolism.
  Nadaoka I, Yasue M, Sami M, Kitagawa Y.Biomed Res. 2012 Apr;33(2):133-7.
• 14. Oral administration of Cimicifuga racemosa extract attenuates immobilization stress-induced reactions.
  Nadaoka I, Watanabe K, Yasue M, Sami M, Kitagawa Y, Mimaki Y.Nat Prod Commun. 2012 Jan;7(1):15-8.
• 15. [Study on fingerprint chromatograms of extract of cimicifugae rhizoma].
  Jin B, Liu Y, Chen H, Peng Y, Zhao Y.Zhongguo Zhong Yao Za Zhi. 2011 Dec;36(24):3475-9. Chinese.
• 16. Chemopreventive potential of black cohosh on breast cancer in Sprague-Dawley rats.
  Einbond LS, Soffritti M, Degli Esposti D, Tibaldi E, Lauriola M, Bua L, He K, Genovese G, Su T, Huggins L, Wang X, Roller M, Wu HA.Anticancer Res. 2012 Jan;32(1):21-30.
• 17. Pharmacological mechanisms of black cohosh in Sprague-Dawley rats.
  Einbond LS, Soffritti M, Esposti DD, Wu HA, Tibaldi E, Lauriola M, He K, Park T, Su T, Huggins L, Wang X, Roller M, Brennan R.Fitoterapia. 2012 Apr;83(3):461-8. doi: 10.1016/j.fitote.2011.12.011. Epub 2011 Dec 16.
• 18. Menopause: a standardized isopropanolic black cohosh extract (remifemin) is found to be safe and effective for menopausal symptoms.
  Ross SM.Holist Nurs Pract. 2012 Jan-Feb;26(1):58-61. doi: 10.1097/HNP.0b013e31823d1f67.
• 19. Black cohosh (Cimicifuga racemosa) relaxes the isolated rat thoracic aorta through endothelium-dependent and -independent mechanisms.
  Kim EY, Lee YJ, Rhyu MR.J Ethnopharmacol. 2011 Nov 18;138(2):537-42. doi: 10.1016/j.jep.2011.09.048. Epub 2011 Oct 1.
• 20. Hops (Humulus lupulus) inhibits oxidative estrogen metabolism and estrogen-induced malignant transformation in human mammary epithelial cells (MCF-10A).
  Hemachandra LP, Madhubhani P, Chandrasena R, Esala P, Chen SN, Main M, Lankin DC, Scism RA, Dietz BM, Pauli GF, Thatcher GR, Bolton JL.Cancer Prev Res (Phila). 2012 Jan;5(1):73-81. doi: 10.1158/1940-6207.CAPR-11-0348. Epub 2011 Oct 13.

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