Standard Herbal Extract

Butterbur Extract Safety Tips

Handling of Butterbur Extract should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Meta-analysis of the impact of the principal venoactive drug agents on malleolar venous edema.
  Allaert FA.Int Angiol. 2012 Aug;31(4):310-5. Review.
• 2. Bioactive compounds, RP-HPLC analysis of phenolics, and antioxidant activity of some Portuguese shrub species extracts.
  Luís A, Domingues F, Duarte AP.Nat Prod Commun. 2011 Dec;6(12):1863-72.
• 3. Steroidal glycosides from the leaves of Ruscus colchicus: isolation and structural elucidation based on a preliminary liquid chromatography-electrospray ionization tandem mass spectrometry profiling.
  Perrone A, Muzashvili T, Napolitano A, Skhirtladze A, Kemertelidze E, Pizza C, Piacente S.Phytochemistry. 2009 Dec;70(17-18):2078-88. doi: 10.1016/j.phytochem.2009.08.016. Epub 2009 Sep 19.
• 4. Changes on venous diameter and leg perimeter with different clinical treatments for moderate chronic venous disease: evaluation using Duplex scanning and perimeter measurements.
  Porto CL, Milhomens AL, Pires CE, Xavier SS, Sicuro F, Bottino DA, Bouskela E.Int Angiol. 2009 Jun;28(3):222-31.
• 5. Use of microcirculatory parameters to evaluate clinical treatments of chronic venous disorder (CVD).
  Lascasas-Porto CL, Milhomens AL, Virgini-Magalhães CE, Fernandes FF, Sicuro FL, Bouskela E.Microvasc Res. 2008 May;76(1):66-72. doi: 10.1016/j.mvr.2008.02.002. Epub 2008 Mar 15.
• 6. Antinociceptive properties of extracts and two flavonoids isolated from leaves of Danae racemosa.
  Maleki-Dizaji N, Fathiazad F, Garjani A.Arch Pharm Res. 2007 Dec;30(12):1536-42.
• 7. Anti-inflammatory activity of Achillea and Ruscus topical gel on carrageenan-induced paw edema in rats.
  Maswadeh HM, Semreen MH, Naddaf AR.Acta Pol Pharm. 2006 Jul-Aug;63(4):277-80.
• 8. Inhibition of COX isoforms by nutraceuticals.
  Seaver B, Smith JR.J Herb Pharmacother. 2004;4(2):11-8.
• 9. Meta-analysis of clinical trials of Cyclo 3 Fort in the treatment of chronic venous insufficiency.
  Boyle P, Diehm C, Robertson C.Int Angiol. 2003 Sep;22(3):250-62.
• 10. [Chronic venous insufficiency: an open trial of FLEBS Crema].
  Consoli A.Minerva Cardioangiol. 2003 Aug;51(4):411-6. Italian.
• 11. Pharmacological targets of drugs employed in chronic venous and lymphatic insufficiency.
  Boisseau MR.Int Angiol. 2002 Jun;21(2 Suppl 1):33-9. Review.
• 12. Efficacy and safety of a Butcher’s broom preparation (Ruscus aculeatus L. extract) compared to placebo in patients suffering from chronic venous insufficiency.
  Vanscheidt W, Jost V, Wolna P, Lücker PW, Müller A, Theurer C, Patz B, Grützner KI.Arzneimittelforschung. 2002;52(4):243-50.
• 13. Formulation and in vitro release of suppositories containing dry extract of Ruscus aculeatus L.
  Peneva B, Krasteva I, Nikolov S, Minkov E.Pharmazie. 2000 Dec;55(12):956. No abstract available.
• 14. HPTLC densitometric determination of ruscogenins in dry extract of Ruscus aculeatus L.
  Peneva B, Krasteva I, Nikolov S, Minkov E.Pharmazie. 2000 Jul;55(7):541-2. No abstract available.
• 15. Pharmacological assessment of adrenergic receptors in human varicose veins.
  Miller VM, Rud KS, Gloviczki P.Int Angiol. 2000 Jun;19(2):176-83.
• 16. Effect of Ruscus extract and hesperidin methylchalcone on hypoxia-induced activation of endothelial cells.
  Bouaziz N, Michiels C, Janssens D, Berna N, Eliaers F, Panconi E, Remacle J.Int Angiol. 1999 Dec;18(4):306-12.
• 17. Antifungal activity of plant extracts against dermatophytes.
  Ali-Shtayeh MS, Abu Ghdeib SI.Mycoses. 1999;42(11-12):665-72.
• 18. Cyclic nucleotides and production of prostanoids in human varicose veins.
  Nemcova S, Gloviczki P, Rud KS, Miller VM.J Vasc Surg. 1999 Nov;30(5):876-83.
• 19. Antimicrobial activity of 20 plants used in folkloric medicine in the Palestinian area.
  Ali-Shtayeh MS, Yaghmour RM, Faidi YR, Salem K, Al-Nuri MA.J Ethnopharmacol. 1998 Apr;60(3):265-71.
• 20. Antipermeability effects of Cyclo 3 Fort in hamsters with moderate diabetes.
  Svensjö E, Bouskela E, Cyrino FZ, Bougaret S.Clin Hemorheol Microcirc. 1997 Sep-Oct;17(5):385-8.

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