Standard Herbal Extract

Celandine Extract Safety Tips

Handling of Celandine Extract should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Studies of biological properties of Uncaria tomentosa extracts on human blood mononuclear cells.
  Bors M, Micha?owicz J, Pilarski R, Sicinska P, Gulewicz K, Bukowska B.J Ethnopharmacol. 2012 Aug 1;142(3):669-78. doi: 10.1016/j.jep.2012.05.036. Epub 2012 Jun 7.
• 2. HPLC-PDA method for quinovic acid glycosides assay in Cat’s claw (Uncaria tomentosa) associated with UPLC/Q-TOF-MS analysis.
  Pavei C, Kaiser S, Verza SG, Borre GL, Ortega GG.J Pharm Biomed Anal. 2012 Mar 25;62:250-7. doi: 10.1016/j.jpba.2011.12.031. Epub 2012 Jan 11.
• 3. Contraceptive effect of Uncaria tomentosa (cat’s claw) in rats with experimental endometriosis.
  Nogueira Neto J, Cavalcante FL, Carvalho RA, Rodrigues TG, Xavier MS, Furtado PG, Schor E.Acta Cir Bras. 2011;26 Suppl 2:15-9.
• 4. Effect of a Herbal-Leucine mix on the IL-1β-induced cartilage degradation and inflammatory gene expression in human chondrocytes.
  Akhtar N, Miller MJ, Haqqi TM.BMC Complement Altern Med. 2011 Aug 19;11:66. doi: 10.1186/1472-6882-11-66.
• 5. Uncaria tomentosa stimulates the proliferation of myeloid progenitor cells.
  Farias I, do Carmo Araújo M, Zimmermann ES, Dalmora SL, Benedetti AL, Alvarez-Silva M, Asbahr AC, Bertol G, Farias J, Schetinger MR.J Ethnopharmacol. 2011 Sep 1;137(1):856-63. doi: 10.1016/j.jep.2011.07.011. Epub 2011 Jul 8.
• 6. Prevention of experimental diabetes by Uncaria tomentosa extract: Th2 polarization, regulatory T cell preservation or both?
  Domingues A, Sartori A, Golim MA, Valente LM, da Rosa LC, Ishikawa LL, Siani AC, Viero RM.J Ethnopharmacol. 2011 Sep 1;137(1):635-42. doi: 10.1016/j.jep.2011.06.021. Epub 2011 Jun 28.
• 7. Uncaria tomentosa aqueous-ethanol extract triggers an immunomodulation toward a Th2 cytokine profile.
  Domingues A, Sartori A, Valente LM, Golim MA, Siani AC, Viero RM.Phytother Res. 2011 Aug;25(8):1229-35. doi: 10.1002/ptr.3549. Epub 2011 Jun 8.
• 8. Anti-inflammatory effects of natural product formulations on murine dendritic cells.
  Miller AK, Benson JM, Muanza DN, Smith JR, Shepherd DM.J Diet Suppl. 2011 Mar;8(1):19-33. doi: 10.3109/19390211.2010.542233.
• 9. Inhibitory mechanisms of two Uncaria tomentosa extracts affecting the Wnt-signaling pathway.
  Gurrola-Díaz CM, García-López PM, Gulewicz K, Pilarski R, Dihlmann S.Phytomedicine. 2011 Jun 15;18(8-9):683-90. doi: 10.1016/j.phymed.2010.11.002. Epub 2010 Dec 14.
• 10. Experimental endometriosis reduction in rats treated with Uncaria tomentosa (cat’s claw) extract.
  Nogueira Neto J, Coelho TM, Aguiar GC, Carvalho LR, de Araújo AG, Girão MJ, Schor E.Eur J Obstet Gynecol Reprod Biol. 2011 Feb;154(2):205-8. doi: 10.1016/j.ejogrb.2010.10.002. Epub 2010 Oct 27.
• 11. Antitumoral and antioxidant effects of a hydroalcoholic extract of cat’s claw (Uncaria tomentosa) (Willd. Ex Roem. & Schult) in an in vivo carcinosarcoma model.
  Dreifuss AA, Bastos-Pereira AL, Avila TV, Soley Bda S, Rivero AJ, Aguilar JL, Acco A.J Ethnopharmacol. 2010 Jul 6;130(1):127-33. doi: 10.1016/j.jep.2010.04.029. Epub 2010 May 6.
• 12. Immunomodulating and antiviral activities of Uncaria tomentosa on human monocytes infected with Dengue Virus-2.
  Reis SR, Valente LM, Sampaio AL, Siani AC, Gandini M, Azeredo EL, D’Avila LA, Mazzei JL, Henriques Md, Kubelka CF.Int Immunopharmacol. 2008 Mar;8(3):468-76. doi: 10.1016/j.intimp.2007.11.010. Epub 2007 Dec 26.
• 13. Select plant tannins induce IL-2Ralpha up-regulation and augment cell division in gammadelta T cells.
  Holderness J, Jackiw L, Kimmel E, Kerns H, Radke M, Hedges JF, Petrie C, McCurley P, Glee PM, Palecanda A, Jutila MA.J Immunol. 2007 Nov 15;179(10):6468-78.
• 14. The potency of immunomodulatory herbs may be primarily dependent upon macrophage activation.
  Groom SN, Johns T, Oldfield PR.J Med Food. 2007 Mar;10(1):73-9.
• 15. Antiproliferative effects of mitraphylline, a pentacyclic oxindole alkaloid of Uncaria tomentosa on human glioma and neuroblastoma cell lines.
  García Prado E, García Gimenez MD, De la Puerta Vázquez R, Espartero Sánchez JL, Sáenz Rodríguez MT.Phytomedicine. 2007 Apr;14(4):280-4. Epub 2007 Feb 12.
• 16. Effect of oral ingestion of an extract of the herb Uncaria tomentosa on the biodistribution of sodium pertechnetate in rats.
  Moreno SR, Silva AL, Diré G, Honeycut H, Carvalho JJ, Nascimento AL, Pereira M, Rocha EK, Oliveira-Timóteo M, Arnobio A, Olej B, Bernardo-Filho M, Caldas LQ.Braz J Med Biol Res. 2007 Jan;40(1):77-80.
• 17. Changes in chromosome structure, mitotic activity and nuclear DNA content from cells of Allium Test induced by bark water extract of Uncaria tomentosa (Willd.) DC.
  Kura? M, Nowakowska J, Sliwinska E, Pilarski R, Ilasz R, Tykarska T, Zobel A, Gulewicz K.J Ethnopharmacol. 2006 Sep 19;107(2):211-21. Epub 2006 Mar 27.
• 18. The chrondoprotective actions of a natural product are associated with the activation of IGF-1 production by human chondrocytes despite the presence of IL-1beta.
  Miller MJ, Ahmed S, Bobrowski P, Haqqi TM.BMC Complement Altern Med. 2006 Apr 7;6:13.
• 19. A water soluble extract from Uncaria tomentosa (Cat’s Claw) is a potent enhancer of DNA repair in primary organ cultures of human skin.
  Mammone T, Akesson C, Gan D, Giampapa V, Pero RW.Phytother Res. 2006 Mar;20(3):178-83.
• 20. Early relief of osteoarthritis symptoms with a natural mineral supplement and a herbomineral combination: a randomized controlled trial [ISRCTN38432711].
  Miller MJ, Mehta K, Kunte S, Raut V, Gala J, Dhumale R, Shukla A, Tupalli H, Parikh H, Bobrowski P, Chaudhary J.J Inflamm (Lond). 2005 Oct 21;2:11.

Details