Botanical Ingredient

Chlorogenic Acid Safety Tips

Handling of Chlorogenic Acid should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

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  Liu Y, Peng XX, Zhu SS, Bai GB.Zhong Yao Cai. 2012 Jul;35(7):1032-6. Chinese.
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• 3. Standardized butanol fraction of WIN-34B suppresses cartilage destruction via inhibited production of matrix metalloproteinase and inflammatory mediator in osteoarthritis human cartilage explants culture and chondrocytes.
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  Hu X, Li WD, Li O, Hao JB, Liu JK.Zhongguo Zhong Yao Za Zhi. 2012 Sep;37(17):2554-7. Chinese.
• 6. Polyphenolic Profile and Biological Activity of Chinese Hawthorn (Crataegus pinnatifida BUNGE) Fruits.
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• 7. Contribution of serum IL-4 and IgE to the early prediction of allergic reactions induced by chlorogenic acid.
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• 8. Antihyperalgesic activity of chlorogenic acid in experimental neuropathic pain.
  Bagdas D, Cinkilic N, Ozboluk HY, Ozyigit MO, Gurun MS.J Nat Med. 2012 Dec 1. [Epub ahead of print]
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• 10. Chlorogenic Acid and Rutin Play a Major Role in the In Vivo Anti-Diabetic Activity of Morus alba Leaf Extract on Type II Diabetic Rats.
  Hunyadi A, Martins A, Hsieh TJ, Seres A, Zupkó I.PLoS One. 2012;7(11):e50619. doi: 10.1371/journal.pone.0050619. Epub 2012 Nov 21.
• 11. Comparative Study on the Inhibitory Effect of Caffeic and Chlorogenic Acids on Key Enzymes Linked to Alzheimer’s Disease and Some Pro-oxidant Induced Oxidative Stress in Rats’ Brain-In Vitro.
  Oboh G, Agunloye OM, Akinyemi AJ, Ademiluyi AO, Adefegha SA.Neurochem Res. 2012 Nov 27. [Epub ahead of print]
• 12. Gastroprotective effect of Hintonia latiflora and Hintonia standleyana aqueous extracts and compounds.
  Cristians S, Bye R, Navarrete A, Mata R.J Ethnopharmacol. 2012 Nov 23. doi:pii: S0378-8741(12)00802-1.  10.1016/j.jep.2012.11.025. [Epub ahead of print]
• 13. Seasonal Variations in the Concentrations of Lipophilic Compounds and Phenolic Acids in the Roots of Echinacea purpurea and Echinacea pallida.
  Thomsen MO, Fretté XC, Christensen KB, Christensen LP, Grevsen K.J Agric Food Chem. 2012 Dec 12;60(49):12131-41. doi: 10.1021/jf303292t. Epub 2012 Dec 3.
• 14. Formation of ester and amine derivatives of 5-o-caffeoylquinic Acid in the process of its simulated extraction.
  Dawidowicz AL, Typek R.J Agric Food Chem. 2012 Dec 19;60(50):12289-95. doi: 10.1021/jf3029682. Epub 2012 Dec 5.
• 15. Quantification of chlorogenic acid and hyperoside directly from crude blueberry (Vaccinium angustifolium) leaf extract by NMR spectroscopy analysis: single-laboratory validation.
  Hicks JM, Muhammad A, Ferrier J, Saleem A, Cuerrier A, Arnason JT, Colson KL.J AOAC Int. 2012 Sep-Oct;95(5):1406-11.
• 16. Quantification of Phenylpropanoids in Commercial Echinacea Products Using TLC with Video Densitometry as Detection Technique and ANN for Data Modelling.
  Agatonovic-Kustrin S, Loescher CM, Singh R.Phytochem Anal. 2012 Nov 22. doi: 10.1002/pca.2411. [Epub ahead of print]
• 17. Chlorogenic acid attenuates HMGB1 and enhances host defense mechanisms in murine sepsis.
  Lee CH, Yoon SJ, Lee SM.Mol Med. 2012 Nov 15. doi: 10.2119/molmed.2012.00279. [Epub ahead of print]
• 18. Development of an automated method for folin-ciocalteu total phenolic assay in artichoke extracts.
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• 19. A novel glutathione-hydroxycinnamic Acid product generated in oxidative wine conditions.
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• 20. Chlorogenic Acid Induces Apoptotic Cell Death in U937 Leukemia Cells through Caspase- and Mitochondria-dependent Pathways.
  Yang JS, Liu CW, Ma YS, Weng SW, Tang NY, Wu SH, Ji BC, Ma CY, Ko YC, Funayama S, Kuo CL.In Vivo. 2012 Nov;26(6):971-8.

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