Botanical Ingredient

Chrysin Safety Tips

Handling of Chrysin should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Alleviation of doxorubicin induced nephrotoxicity and hepatotoxicity by chrysin in wistar rats.
  Rashid S, Ali N, Nafees S, Tanveer Ahmad S, Arjumand W, Kazim Hasan S, Sultana S.Toxicol Mech Methods. 2012 Dec 20. [Epub ahead of print]
• 2. Inhibition of Tumor Cells Proliferation and Migration by the Flavonoid Furin Inhibitor Isolated from Oroxylum Indicum.
  Lalou C, Basak A, Mishra P, Mohanta BC, Banik R, Dinda B, Khatib AM.Curr Med Chem. 2012 Dec 3. [Epub ahead of print]
• 3. Polyphenols inhibit indoleamine 3,5-dioxygenase-1 enzymatic activity — a role of immunomodulation in chemoprevention.
  Chen SS, Corteling R, Stevanato L, Sinden J.Discov Med. 2012 Nov;14(78):327-33.
• 4. Chrysin suppresses renal carcinogenesis via amelioration of hyperproliferation, oxidative stress and inflammation: Plausible role of NF-κB.
  Rehman MU, Tahir M, Khan AQ, Lateef A, Khan R, Oday-O-Hamiza, Qamar W, Ali F, Sultana S.Toxicol Lett. 2012 Nov 27. doi:pii: S0378-4274(12)01386-0.  10.1016/j.toxlet.2012.11.013. [Epub ahead of print]
• 5. Ethanolic extract of propolis, chrysin, Cape inhibit human astroglia cells.
  Markiewicz-?ukowska R, Car H, Naliwajko S, Sawicka D, Szynaka B, Chyczewski L, Isidorov V, Borawska M.Adv Med Sci. 2012 Nov 22:15-23. doi: 10.2478/v10039-012-0042-6. [Epub ahead of print]
• 6. Preconcentration of flavonoids on polyurethane foam and their direct determination by diffuse reflectance spectroscopy.
  Dmitrienko SG, Apyari VV, Kudrinskaya VA, Stepanova AV.Talanta. 2012 Dec 15;102:132-6. doi: 10.1016/j.talanta.2012.08.017. Epub 2012 Aug 21.
• 7. Identification and Quantification of Phytochemical Composition and Anti-inflammatory and Radical Scavenging Properties of Methanolic Extracts of Chinese Propolis.
  Shi H, Yang H, Zhang X, Yu LL.J Agric Food Chem. 2012 Dec 19;60(50):12403-10. doi: 10.1021/jf3042775. Epub 2012 Dec 5.
• 8. Effect of Chrysin on Gene Expression and Production of MUC5AC Mucin from Cultured Airway Epithelial Cells.
  Shin HD, Lee HJ, Sikder MA, Park SH, Ryu J, Hong JH, Kim JO, Seok JH, Lee CJ.Tuberc Respir Dis (Seoul). 2012 Oct;73(4):204-9. doi: 10.4046/trd.2012.73.4.204. Epub 2012 Oct 31.
• 9. Influences of glucose on the dietary hydroxyflavonoid-plasma protein interaction.
  Wang Y, Zhao Y, Yang F, Yuan Y, Wang H, Xiao J.J Agric Food Chem. 2012 Dec 12;60(49):12116-21. doi: 10.1021/jf303094e. Epub 2012 Nov 28.
• 10. Chrysin: a histone deacetylase 8 inhibitor with anticancer activity and a suitable candidate for the standardization of chinese propolis.
  Sun LP, Chen AL, Hung HC, Chien YH, Huang JS, Huang CY, Chen YW, Chen CN.J Agric Food Chem. 2012 Nov 28;60(47):11748-58. doi: 10.1021/jf303261r. Epub 2012 Nov 15.
• 11. Naringenin degradation by the endophytic diazotroph Herbaspirillum seropedicae SmR1.
  Marin AM, Souza EM, Pedrosa FO, Souza LM, Sassaki GL, Baura VA, Yates MG, Wassem R, Monteiro RA.Microbiology. 2012 Nov 1. [Epub ahead of print]
• 12. Evaluation of the structure-activity relationship of flavonoids as antioxidants and toxicants of zebrafish larvae.
  Chen YH, Yang ZS, Wen CC, Chang YS, Wang BC, Hsiao CA, Shih TL.Food Chem. 2012 Sep 15;134(2):717-24. doi: 10.1016/j.foodchem.2012.02.166. Epub 2012 Mar 6.
• 13. Antihypercholesterolemic and antioxidative effects of an extract of the oyster mushroom, Pleurotus ostreatus, and its major constituent, chrysin, in Triton WR-1339-induced hypercholesterolemic rats.
  Anandhi R, Annadurai T, Anitha TS, Muralidharan AR, Najmunnisha K, Nachiappan V, Thomas PA, Geraldine P.J Physiol Biochem. 2012 Oct 27. [Epub ahead of print]
• 14. Heme binding site in apomyoglobin may be effectively targeted with small molecules to control aggregation.
  Movahed MA, Shariatizi S, Sabbaghian M, Ghasemi A, Ebrahim-Habibi A, Nemat-Gorgani M.Int J Biochem Cell Biol. 2012 Oct 23. doi:pii: S1357-2725(12)00340-8.  10.1016/j.biocel.2012.10.004. [Epub ahead of print]
• 15. Natural inhibitors of indoleamine 3,5-dioxygenase induced by interferon-gamma in human neural stem cells.
  Chen S, Corteling R, Stevanato L, Sinden J.Biochem Biophys Res Commun. 2012 Dec 7;429(1-2):117-23. doi: 10.1016/j.bbrc.2012.10.009. Epub 2012 Oct 12.
• 16. HPLC Determination of the Major Active Flavonoids and GC-MS Analysis of Volatile Components of Dysphania graveolens (Amaranthaceae).
  Alvarez-Ospina H, Rivero Cruz I, Duarte G, Bye R, Mata R.Phytochem Anal. 2012 Oct 5. doi: 10.1002/pca.2405. [Epub ahead of print]
• 17. Chrysin activates Notch1 signaling and suppresses tumor growth of anaplastic thyroid carcinoma in vitro and in vivo.
  Yu XM, Phan T, Patel PN, Jaskula-Sztul R, Chen H.Cancer. 2012 Sep 18. doi: 10.1002/cncr.27742. [Epub ahead of print]
• 18. Induction of apoptosis by 7-piperazinethylchrysin in HCT-116 human colon cancer cells.
  Ren J, Cheng H, Xin WQ, Chen X, Hu K.Oncol Rep. 2012 Nov;28(5):1719-26. doi: 10.3892/or.2012.2016. Epub 2012 Sep 4.
• 19. A Review of the Taxonomy, Ethnobotany, Chemistry and Pharmacology of Oroxylum indicum Vent.
  Harminder, Singh V, Chaudhary AK.Indian J Pharm Sci. 2011 Sep;73(5):483-90. doi: 10.4103/0250-474X.98981.
• 20. Drug screening study using glioma stem-like cells.
  Feng X, Zhou Q, Liu C, Tao ML.Mol Med Report. 2012 Nov;6(5):1117-20. doi: 10.3892/mmr.2012.1040. Epub 2012 Aug 20.

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