Botanical Ingredient

Cryptotanshinone Safety Tips

Handling of Cryptotanshinone should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Inhibition of Hypoxia Inducible Factor Alpha and Astrocyte-Elevated Gene-1 Mediates Cryptotanshinone Exerted Antitumor Activity in Hypoxic PC-3 Cells.
  Lee HJ, Jung DB, Sohn EJ, Kim HH, Park MN, Lew JH, Lee SG, Kim B, Kim SH.Evid Based Complement Alternat Med. 2012;2012:390957. doi: 10.1155/2012/390957. Epub 2012 Nov 29.
• 2. Enzyme kinetic and molecular docking studies for the inhibitions of miltirone on major human cytochrome P450 isozymes.
  Zhou X, Wang Y, Hu T, Or PM, Wong J, Kwan YW, Wan DC, Hoi PM, Lai PB, Yeung JH.Phytomedicine. 2012 Oct 25. doi:pii: S0944-7113(12)00357-1.  10.1016/j.phymed.2012.09.021. [Epub ahead of print]
• 3. Tanshinone derivatives: a patent review (January 2006 – September 2012).
  Tian XH, Wu JH.Expert Opin Ther Pat. 2013 Jan;23(1):19-29. doi: 10.1517/13543776.2013.736494. Epub 2012 Oct 25.
• 4. Coexisted components of Salvia miltiorrhiza enhance intestinal absorption of cryptotanshinone via inhibition of the intestinal P-gp.
  Dai H, Li X, Li X, Bai L, Li Y, Xue M.Phytomedicine. 2012 Nov 15;19(14):1256-62. doi: 10.1016/j.phymed.2012.08.007. Epub 2012 Oct 5.
• 5. Comparison of neuroprotective effects of five major lipophilic diterpenoids from Danshen extract against experimentally induced transient cerebral ischemic damage.
  Park OK, Choi JH, Park JH, Kim IH, Yan BC, Ahn JH, Kwon SH, Lee JC, Kim YS, Kim M, Kang IJ, Kim JD, Lee YL, Won MH.Fitoterapia. 2012 Dec;83(8):1666-74. doi: 10.1016/j.fitote.2012.09.020. Epub 2012 Sep 28.
• 6. [Chemical constituents contained in Salvia castanea].
  Qu G, Yue X, An F, Dai S, Li G, Li B.Zhongguo Zhong Yao Za Zhi. 2012 Jul;37(13):1985-9. Chinese.
• 7. Enhancement of solubility and dissolution rate of cryptotanshinone, tanshinone I and tanshinone IIA extracted from Salvia miltiorrhiza.
  Yu H, Subedi RK, Nepal PR, Kim YG, Choi HK.Arch Pharm Res. 2012 Aug;35(8):1457-64. doi: 10.1007/s12272-012-0816-1. Epub 2012 Sep 1.
• 8. On-line ionic liquid-based dynamic microwave-assisted extraction-high performance liquid chromatography for the determination of lipophilic constituents in root of Salvia miltiorrhiza Bunge.
  Gao S, Yu W, Yang X, Liu Z, Jia Y, Zhang H.J Sep Sci. 2012 Oct;35(20):2813-21. doi: 10.1002/jssc.201200267. Epub 2012 Aug 21.
• 9. Three-channel column-switching high-performance liquid chromatography with electrochemical detection for determining bioactive redox components in Salvia miltiorrhiza.
  Chen X, Kotani A, Hakamata H, Wang J, Du S, Kusu F.J Chromatogr A. 2012 Sep 21;1256:105-13. doi: 10.1016/j.chroma.2012.07.061. Epub 2012 Jul 27.
• 10. Cryptotanshinone and tanshinone IIA enhance IL-15-induced natural killer cell differentiation.
  Kim WS, Kim DO, Yoon SJ, Kim MJ, Yoon SR, Park YJ, Jung H, Kim TD, Kwon BM, Choi I.Biochem Biophys Res Commun. 2012 Aug 24;425(2):340-7. doi: 10.1016/j.bbrc.2012.07.093. Epub 2012 Jul 26.
• 11. Metabolism of tanshinone IIA, cryptotanshinone and tanshinone I from Radix Salvia miltiorrhiza in zebrafish.
  Wei Y, Li P, Wang C, Peng Y, Shu L, Jia X, Ma W, Wang B.Molecules. 2012 Jul 18;17(7):8617-32. doi: 10.3390/molecules17078617.
• 12. Screening of bioactive compounds in Radix Salviae Miltiorrhizae with liposomes and cell membranes using HPLC.
  Chen X, Deng Y, Xue Y, Liang J.J Pharm Biomed Anal. 2012 Nov;70:194-201. doi: 10.1016/j.jpba.2012.06.030. Epub 2012 Jun 28.
• 13. [Simultaneous determination of four tanshinones in Salvia miltiorrhiza by QAMS].
  Li Q, Liu W, Luo Z, Yang M.Zhongguo Zhong Yao Za Zhi. 2012 Mar;37(6):824-8. Chinese.
• 14. Cryptotanshinone induces cell cycle arrest and apoptosis of multidrug resistant human chronic myeloid leukemia cells by inhibiting the activity of eukaryotic initiation factor 4E.
  Ge Y, Cheng R, Zhou Y, Shen J, Peng L, Xu X, Dai Q, Liu P, Wang H, Ma X, Jia J, Chen Z.Mol Cell Biochem. 2012 Sep;368(1-2):17-25. doi: 10.1007/s11010-012-1338-3. Epub 2012 May 22.
• 15. Modeling gradient elution in countercurrent chromatography: efficient separation of tanshinones from Salvia miltiorrhiza Bunge.
  Wu S, Wu D, Liang J, Berthod A.J Sep Sci. 2012 Apr;35(8):964-76. doi: 10.1002/jssc.201100993.
• 16. Molecular docking and enzyme kinetic studies of dihydrotanshinone on metabolism of a model CYP2D6 probe substrate in human liver microsomes.
  Zhou X, Wang Y, Or PM, Wan DC, Kwan YW, Yeung JH.Phytomedicine. 2012 May 15;19(7):648-57. doi: 10.1016/j.phymed.2012.01.005. Epub 2012 Apr 27.
• 17. Cryptotanshinone attenuates isoprenaline-induced cardiac fibrosis in             mice associated with upregulation and activation of matrix metalloproteinase-2.
  Ma S, Yang D, Wang K, Tang B, Li D, Yang Y.Mol Med Report. 2012 Jul;6(1):145-50. doi: 10.3892/mmr.2012.866. Epub 2012 Apr 11.
• 18. Growth-inhibitory and apoptosis-inducing effects of tanshinones on hematological malignancy cells and their structure-activity relationship.
  Li H, Zhang Q, Chu T, Shi HY, Fu HM, Song XR, Meng WT, Mao SJ, Jia YQ.Anticancer Drugs. 2012 Sep;23(8):846-55.
• 19. Cryptotanshinone activates p38/JNK and inhibits Erk1/2 leading to caspase-independent cell death in tumor cells.
  Chen W, Liu L, Luo Y, Odaka Y, Awate S, Zhou H, Shen T, Zheng S, Lu Y, Huang S.Cancer Prev Res (Phila). 2012 May;5(5):778-87. doi: 10.1158/1940-6207.CAPR-11-0551. Epub 2012 Apr 3.
• 20. Bioassay-guided isolation of fatty acid synthase inhibitory diterpenoids from the roots of Salvia miltiorrhiza Bunge.
  Jang TS, Zhang H, Kim G, Kim DW, Min BS, Kang W, Son KH, Na M, Lee SH.Arch Pharm Res. 2012 Mar;35(3):481-6. doi: 10.1007/s12272-012-0311-8. Epub 2012 Apr 5.

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