Botanical Ingredient

D-Pinitol Safety Tips

Handling of D-Pinitol should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. D-Pinitol attenuates 7, 12 dimethylbenz [a] anthracene induced hazards through modulating protein bound carbohydrates, adenosine triphosphatases and lysosomal enzymes during experimental mammary carcinogenesis.
  Rengarajan T, Nandakumar N, Balasubramanian MP.J Exp Ther Oncol. 2012;10(1):39-49.
• 2. Antihyperglycemic Activity of Extracts from Boldoa purpurascens Leaves in Alloxan-Induced Diabetic Rats.
  González Mosquera DM, Hernandez Ortega Y, By B, Vicet Muro L, Saucedo Hernandez Y, Grau Ábalos R, Dehaen W, Pieters L, Apers S.Phytother Res. 2012 Jul 17. doi: 10.1002/ptr.4769. [Epub ahead of print]
• 3. D-chiro-inositol Negatively Regulates the Formation of Multinucleated Osteoclasts by Down-Regulating NFATc1.
  Yu J, Choi S, Park ES, Shin B, Yu J, Lee SH, Takami M, Kang JS, Meong H, Rho J.J Clin Immunol. 2012 Jun 19. [Epub ahead of print]
• 4. Interactions between phytochemical components of Sutherlandia frutescens and the antiretroviral, atazanavir in vitro: implications for absorption and metabolism.
  Müller AC, Patnala S, Kis O, Bendayan R, Kanfer I.J Pharm Pharm Sci. 2012 Jan;15(2):221-33.
• 5. D-pinitol inhibits RANKL-induced osteoclastogenesis.
  Liu SC, Chuang SM, Tang CH.Int Immunopharmacol. 2012 Mar;12(3):494-500. doi: 10.1016/j.intimp.2012.01.002. Epub 2012 Jan 23.
• 6. GATA binding protein 3 overexpression and suppression significantly contribute to the regulation of allergic skin inflammation.
  Bae CJ, Lee JW, Shim SB, Jee SW, Lee SH, Woo JM, Lee CK, Hwang DY.Int J Mol Med. 2011 Aug;28(2):171-9. doi: 10.3892/ijmm.2011.685. Epub 2011 Apr 28.
• 7. Determination of D-pinitol in carob syrup.
  Tetik N, Turhan I, Oziyci HR, Karhan M.Int J Food Sci Nutr. 2011 Sep;62(6):572-6. doi: 10.3109/09637486.2011.560564. Epub 2011 Apr 5.
• 8. Free cyclitol, soluble carbohydrate and protein contents in Vigna unguiculata and Phaseolus vulgaris bean sprouts.
  Ribeiro Eda S, Centeno Dda C, Figueiredo-Ribeiro Rde C, Fernandes KV, Xavier-Filho J, Oliveira AE.J Agric Food Chem. 2011 Apr 27;59(8):4273-8. doi: 10.1021/jf104979m. Epub 2011 Mar 31.
• 9. D-chiro-inositol affects accumulation of raffinose family oligosaccharides in developing embryos of Pisum sativum.
  Lahuta LB, Dzik T.J Plant Physiol. 2011 Mar 1;168(4):352-8. doi: 10.1016/j.jplph.2010.07.027. Epub 2010 Oct 13.
• 10. Plant physiology and proteomics reveals the leaf response to drought in alfalfa (Medicago sativa L.).
  Aranjuelo I, Molero G, Erice G, Avice JC, Nogués S.J Exp Bot. 2011 Jan;62(1):111-23. doi: 10.1093/jxb/erq249. Epub 2010 Aug 25.
• 11. Impact of D-pinitol on the attenuation of proinflammatory cytokines, hyperglycemia-mediated oxidative stress and protection of kidney tissue ultrastructure in streptozotocin-induced diabetic rats.
  Sivakumar S, Palsamy P, Subramanian SP.Chem Biol Interact. 2010 Oct 6;188(1):237-45. doi: 10.1016/j.cbi.2010.07.014. Epub 2010 Jul 17.
• 12. D-pinitol and myo-inositol stimulate translocation of glucose transporter 4 in skeletal muscle of C57BL/6 mice.
  Dang NT, Mukai R, Yoshida K, Ashida H.Biosci Biotechnol Biochem. 2010;74(5):1062-7. Epub 2010 May 7.
• 13. Attenuation of oxidative stress and alteration of hepatic tissue ultrastructure by D-pinitol in streptozotocin-induced diabetic rats.
  Sivakumar S, Palsamy P, Subramanian SP.Free Radic Res. 2010 Jun;44(6):668-78. doi: 10.3109/10715761003733901.
• 14. D-pinitol attenuates the impaired activities of hepatic key enzymes in carbohydrate metabolism of streptozotocin-induced diabetic rats.
  Sivakumar S, Subramanian SP.Gen Physiol Biophys. 2009 Sep;28(3):233-41.
• 15. [Chemical constituents from leaves of Albizia chinensis].
  Liu R, Yu S, Pei Y.Zhongguo Zhong Yao Za Zhi. 2009 Aug;34(16):2063-6. Chinese.
• 16. The effects of creatine monohydrate supplementation with and without D-pinitol on resistance training adaptations.
  Kerksick CM, Wilborn CD, Campbell WI, Harvey TM, Marcello BM, Roberts MD, Parker AG, Byars AG, Greenwood LD, Almada AL, Kreider RB, Greenwood M.J Strength Cond Res. 2009 Dec;23(9):2673-82. doi: 10.1519/JSC.0b013e3181b3e0de.
• 17. Pancreatic tissue protective nature of D-Pinitol studied in streptozotocin-mediated oxidative stress in experimental diabetic rats.
  Sivakumar S, Subramanian SP.Eur J Pharmacol. 2009 Nov 10;622(1-3):65-70. doi: 10.1016/j.ejphar.2009.09.021. Epub 2009 Sep 16.
• 18. D-(+)-pinitol, a component of the heartwood of Enterolobium cyclocarpum (Jacq.) Griseb.
  Raya-Gonzalez D, Pamatz-Bolaños T, del Rio-Torres RE, Martinez-Muñoz RE, Ron-Echeverria O, Martinez-Pacheco MM.Z Naturforsch C. 2008 Nov-Dec;63(11-12):922-4.
• 19. Rat L6 myotubes as an in vitro model system to study GLUT4-dependent glucose uptake stimulated by inositol derivatives.
  Yap A, Nishiumi S, Yoshida K, Ashida H.Cytotechnology. 2007 Dec;55(2-3):103-8. doi: 10.1007/s10616-007-9107-y. Epub 2007 Oct 31.
• 20. Antihyperlipidemic effect of D-pinitol on streptozotocin-induced diabetic Wistar rats.
  Geethan PK, Prince PS.J Biochem Mol Toxicol. 2008 Jul-Aug;22(4):220-4. doi: 10.1002/jbt.20218.

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