Botanical Ingredient

Daidzein Safety Tips

Handling of Daidzein should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Pharmacokinetics and Relative Bioavailability of Flavonoids between Two Dosage Forms of Gegen-Qinlian-Tang in Rats.
  Yu CP, Shia CS, Tsai SY, Hou YC.Evid Based Complement Alternat Med. 2012;2012:308018. doi: 10.1155/2012/308018. Epub 2012 Nov 1.
• 2. A new daidzein derivative from endophytic Streptomyces sp. YIM 65408.
  Yang Y, Yang X, Zhang Y, Zhou H, Zhang J, Xu L, Ding Z.Nat Prod Res. 2012 Dec 21. [Epub ahead of print]
• 3. Homocysteine, heat shock proteins, genistein and vitamins in ischemic stroke – pathogenic and therapeutic implications.
  Banecka-Majkutewicz Z, Sawu?a W, Kadzinski L, W?grzyn A, Banecki B.Acta Biochim Pol. 2012 Dec 19. [Epub ahead of print]
• 4. Simultaneous monitoring of seven phenolic metabolites of endocrine disrupting compounds (EDC) in human urine using gas chromatography with tandem mass spectrometry.
  Schmidt L, Müller J, Göen T.Anal Bioanal Chem. 2012 Dec 16. [Epub ahead of print]
• 5. Anti-breast cancer potential of daidzein in rodents.
  Liu X, Suzuki N, Santosh Laxmi YR, Okamoto Y, Shibutani S.Life Sci. 2012 Oct 5;91(11-12):415-9.
• 6. Effects of the natural endocrine disruptor equol on the pituitary function in adult male rats.
  Loutchanwoot P, Srivilai P, Jarry H.Toxicology. 2012 Dec 7. doi:pii: S0300-483X(12)00414-3.  10.1016/j.tox.2012.11.017. [Epub ahead of print]
• 7. Daidzein-estrogen interaction in the rat uterus and its effect on human breast cancer cell growth.
  Gaete L, Tchernitchin AN, Bustamante R, Villena J, Lemus I, Gidekel M, Cabrera G, Astorga P.J Med Food. 2012 Dec;15(12):1081-90. doi: 10.1089/jmf.2011.0322. Epub 2012 Dec 10.
• 8. A comparative analysis of the photo-protective effects of  soy isoflavones in their aglycone and glucoside forms.
  Iovine B, Iannella ML, Gasparri F, Giannini V, Monfrecola G, Bevilacqua MA.Int J Mol Sci. 2012 Dec 4;13(12):16444-56. doi: 10.3390/ijms131216444.
• 9. Contrasting binding of fisetin and daidzein in γ-cyclodextrin nanocavity.
  Pahari B, Sengupta B, Chakraborty S, Thomas B, McGowan D, Sengupta PK.J Photochem Photobiol B. 2012 Nov 1. doi:pii: S1011-1344(12)00228-X.  10.1016/j.jphotobiol.2012.10.010. [Epub ahead of print]
• 10. Mechanisms underlying the dualistic mode of action of major soy isoflavones in relation to cell proliferation and cancer risks.
  Rietjens IM, Sotoca AM, Vervoort J, Louisse J.Mol Nutr Food Res. 2012 Nov 23. doi: 10.1002/mnfr.201200439. [Epub ahead of print]
• 11. Effects of dietary genistein on hormone-dependent rat mammary carcinogenesis induced by ethyl methanesulphonate.
  Ono M, Koga T, Ueo H, Nakano S.Nutr Cancer. 2012 Nov;64(8):1204-10. doi: 10.1080/01635581.2012.718035.
• 12. Isoflavones: estrogenic activity, biological effect and bioavailability.
  Vitale DC, Piazza C, Melilli B, Drago F, Salomone S.Eur J Drug Metab Pharmacokinet. 2012 Nov 17. [Epub ahead of print]
• 13. A modified QuEChERS method as sample treatment before the determination of isoflavones in foods by ultra-performance liquid chromatography-triple quadrupole mass spectrometry.
  Delgado-Zamarreño MM, Pérez-Martín L, Bustamante-Rangel M, Carabias-Martínez R.Talanta. 2012 Oct 15;100:320-8. doi: 10.1016/j.talanta.2012.07.070. Epub 2012 Aug 16.
• 14. Androgen deprivation by flutamide modulates uPAR, MMP-9 expressions, lipid profile, and oxidative stress: amelioration by daidzein.
  Lateef A, Khan AQ, Tahir M, Khan R, Rehman MU, Ali F, Hamiza OO, Sultana S.Mol Cell Biochem. 2012 Nov 8. [Epub ahead of print]
• 15. Mass spectrometry-based metabolite profiling and bacterial diversity characterization of korean traditional meju during fermentation.
  Lee SY, Kim HY, Lee S, Lee JM, Muthaiya MJ, Kim BS, Oh JY, Song CK, Jeon EJ, Ryu HS, Lee CH.J Microbiol Biotechnol. 2012 Nov;22(11):1523-31.
• 16. [Microbial conversion of daidzein affects fecal equol concentration and bacterial composition of rats with or without ovariectomy].
  Zhang X, Zheng W, Huang S, Yao W.Wei Sheng Wu Xue Bao. 2012 Jul 4;52(7):866-74. Chinese.
• 17. Isoflavones, genistein and daidzein, regulate mucosal immune response by suppressing dendritic cell function.
  Wei J, Bhatt S, Chang LM, Sampson HA, Masilamani M.PLoS One. 2012;7(10):e47979. doi: 10.1371/journal.pone.0047979. Epub 2012 Oct 22.
• 18. Genistein and daidzein, typical soy isoflavones, inhibit TNF-α-mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes.
  Yanagisawa M, Sugiya M, Iijima H, Nakagome I, Hirono S, Tsuda T.Mol Nutr Food Res. 2012 Dec;56(12):1783-93. doi: 10.1002/mnfr.201200284. Epub 2012 Oct 29.
• 19. The Soy Isoflavone Equol May Increase Cancer Malignancy via Up-regulation of Eukaryotic Protein Synthesis Initiation Factor eIF4G.
  de la Parra C, Otero-Franqui E, Martinez-Montemayor M, Dharmawardhane S.J Biol Chem. 2012 Dec 7;287(50):41640-50. doi: 10.1074/jbc.M112.393470. Epub 2012 Oct 24.
• 20. Inhibition of ABCG2/BCRP transporter by soy isoflavones genistein and daidzein: Effect on plasma and milk levels of danofloxacin in sheep.
  Perez M, Otero JA, Barrera B, Prieto JG, Merino G, Alvarez AI.Vet J. 2012 Oct 17. doi:pii: S1090-0233(12)00397-8.  10.1016/j.tvjl.2012.09.012. [Epub ahead of print]

Details