Botanical Ingredient

References

• 1. Validated Stability Indicating TLC-Densitometric Method for the Determination of Diacerein.
  Ali NW, Abdelwahab NS, Abdelkawy M, Emam AA.J Chromatogr Sci. 2012 Dec 20. [Epub ahead of print]
• 2. Studies on synthesis, stability, release and pharmacodynamic profile of a novel diacerein-thymol prodrug.
  Dhaneshwar S, Patel V, Patil D, Meena G.Bioorg Med Chem Lett. 2013 Jan 1;23(1):55-61. doi: 10.1016/j.bmcl.2012.11.016. Epub 2012 Nov 16.
• 3. Synthesis and pharmacokinetic profile of rhein- boswellic acid conjugate.
  Suneela D, Dipmala P.Bioorg Med Chem Lett. 2012 Dec 15;22(24):7582-7. doi: 10.1016/j.bmcl.2012.10.017. Epub 2012 Oct 11.
• 4. Nutraceuticals in the management of osteoarthritis : a critical review.
  Ragle RL, Sawitzke AD.Drugs Aging. 2012 Sep;29(9):717-31.
• 5. [Clinical study of Qianggu granule and diacerein capsule in treating knee osteoarthritis].
  Wang FS, Wu QF, Qi JM.Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 Jun;32(6):779-81, 792. Chinese.
• 6. Chondromodulating Chimeric Prodrugs of Diacetylrhein: Synthesis and Evaluation in Monoiodoacetate-induced Hyperalgesia.
  Dhaneshwar S, Patil D.Med Chem. 2012 Aug 17. [Epub ahead of print]
• 7. Diacerein decreases visceral pain through inhibition of glutamatergic neurotransmission and cytokine signaling in mice.
  Gadotti VM, Martins DF, Pinto HF, Oliveira G, Kaster MP, Quintão NL, Santos AR.Pharmacol Biochem Behav. 2012 Oct;102(4):549-54. doi: 10.1016/j.pbb.2012.06.018. Epub 2012 Jun 28.
• 8. [Management of osteoarthritis: oral therapies].
  Richette P.Rev Prat. 2012 May;62(5):654-60. Review. French.
• 9. Combined effect of subchondral drilling and hyaluronic acid with/without diacerein in full-thickness articular cartilage lesion in rabbits.
  Suwannaloet W, Laupattarakasem W, Sukon P, Ong-Chai S, Laupattarakasem P.ScientificWorldJournal. 2012;2012:310745. doi: 10.1100/2012/310745. Epub 2012 Apr 30.
• 10. Fast-dissolving and high-drug-loaded, Fatty Acid-based self-emulsifying solid dispersions of diacerein.
  Aggarwal AK, Singh S.PDA J Pharm Sci Technol. 2012 May-Jun;66(3):201-13. doi: 10.5731/pdajpst.2012.00857.
• 11. Diacerein: a potential therapeutic drug for periodontal disease.
  Huang RY, Lu SH, Su KW, Chen JK, Fang WH, Liao WN, Chen SY, Shieh YS.Med Hypotheses. 2012 Aug;79(2):165-7. doi: 10.1016/j.mehy.2012.04.024. Epub 2012 May 13.
• 12. [Clinical efficacy of bushen huoxue qubi decoction on treatment of knee-osteoarthritis and its effect on hemarheology, anti-inflammation and antioxidation].
  Gao G, Wu H, Tian J, Du J, Xie X, Gao J.Zhongguo Zhong Yao Za Zhi. 2012 Feb;37(3):390-6. Chinese.
• 13. Diacerein as adjuvant to diclofenac sodium in osteoarthritis knee.
  Singh K, Sharma R, Rai J.Int J Rheum Dis. 2012 Feb;15(1):69-77. doi: 10.1111/j.1756-185X.2011.01648.x. Epub 2011 Sep 6.
• 14. Comment on: Ramos-Zavala et al. Effect of diacerein on insulin secretion and metabolic control in drug-naïve patients with type 2 diabetes: a randomized clinical trial. Diabetes Care 2011;34:1591-1594.
  Tobar N, Oliveira AG, Guadagnini D, Bagarolli RA, Rocha GZ, Araujo TG, Prada PO, Saad MJ.Diabetes Care. 2012 Feb;35(2):e13; author reply e14. doi: 10.2337/dc11-1856. No abstract available.
• 15. A comparison of the therapeutic efficacy of diclofenac in osteoarthritis: a systematic review of randomised controlled trials.
  Pavelka K.Curr Med Res Opin. 2012 Jan;28(1):163-78. doi: 10.1185/03007995.2011.649848. Review.
• 16. [Pharmacological therapies for osteoarthritis].
  Richette P.Therapie. 2011 Sep-Oct;66(5):383-90. doi: 10.2515/therapie/2011060. Epub 2011 Oct 27. Review. French.
• 17. Rhein: a potential biological therapeutic drug for intervertebral disc degeneration.
  Li H, Liang C, Chen Q, Yang Z.Med Hypotheses. 2011 Dec;77(6):1105-7. doi: 10.1016/j.mehy.2011.09.013. Epub 2011 Sep 29.
• 18. Diacerhein improves glucose tolerance and insulin sensitivity in mice on a high-fat diet.
  Tobar N, Oliveira AG, Guadagnini D, Bagarolli RA, Rocha GZ, Araújo TG, Santos-Silva JC, Zollner RL, Boechat LH, Carvalheira JB, Prada PO, Saad MJ.Endocrinology. 2011 Nov;152(11):4080-93. doi: 10.1210/en.2011-0249. Epub 2011 Sep 6.
• 19. Effect of diacerein on insulin secretion and metabolic control in drug-naive patients with type 2 diabetes: a randomized clinical trial.
  Ramos-Zavala MG, González-Ortiz M, Martínez-Abundis E, Robles-Cervantes JA, González-López R, Santiago-Hernández NJ.Diabetes Care. 2011 Jul;34(7):1591-4. doi: 10.2337/dc11-0357. Epub 2011 May 24.
• 20. Stability-indicating spectrophotometric and spectrodensitometric methods for the determination of diacerein in the presence of its degradation product.
  Nebsen M, Abd El-Rahman MK, Salem MY, El-Kosasy AM, El-Bardicy MG.Drug Test Anal. 2011 Apr;3(4):221-7. doi: 10.1002/dta.213. Epub 2010 Dec 29.