Botanical Ingredient

Dihydroartemisinin Safety Tips

Handling of Dihydroartemisinin should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Heat stabilization of blood spot samples for determination of metabolically unstable drug compounds.
  Blessborn D, Sköld K, Zeeberg D, Kaewkhao K, Sköld O, Ahnoff M.Bioanalysis. 2013 Jan;5(1):31-9. doi: 10.4155/bio.12.294.
• 2. Randomized, Open Label Trial of Primaquine Against Vivax Malaria Relapse in Indonesia.
  Sutanto I, Tjahjono B, Basri H, Taylor WR, Putri FA, Meilia RA, Setiabudy R, Nurleila S, Ekawati LL, Elyazar I, Farrar J, Sudoyo H, Baird JK.Antimicrob Agents Chemother. 2012 Dec 17. [Epub ahead of print]
• 3. Antimalarial activity of 10-alkyl/aryl esters and -aminoethylethers of artemisinin.
  Cloete TT, Krebs HJ, Clark JA, Connelly MC, Orcutt A, Sigal MS, Kiplin Guy R, N’da DD.Bioorg Chem. 2012 Nov 3;46C:10-16. doi: 10.1016/j.bioorg.2012.10.002. [Epub ahead of print]
• 4. [Anti-inflammatory effect and mechanism of artemisinin and dihydroartemisinin].
  Yu WY, Kan WJ, Yu PX, Li MM, Song JS, Zhao F.Zhongguo Zhong Yao Za Zhi. 2012 Sep;37(17):2618-21. Chinese.
• 5. The effect of single nucleotide polymorphisms in cytochrome P450 isoenzyme and N-acetyltransferase-2 genes on the metabolism of artemisinin-based combination therapies in malaria patients from Cambodia and Tanzania.
  Hodel EM, Csajka C, Ariey F, Guidi M, Kabanywanyi AM, Duong S, Decosterd LA, Olliaro P, Beck HP, Genton B.Antimicrob Agents Chemother. 2012 Dec 10. [Epub ahead of print]
• 6. Efficacy and safety of dihydroartemisinin-piperaquine for treatment of uncomplicated Plasmodium falciparum malaria in endemic countries: meta-analysis of randomised controlled studies.
  Naing C, Mak JW, Aung K, Wong JY.Trans R Soc Trop Med Hyg. 2012 Dec 4. [Epub ahead of print]
• 7. Efficacy of dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum and Plasmodium vivax in Cambodia, 2008-2010.
  Leang R, Barrette A, Mey Bouth D, Menard D, Abdur R, Duong S, Ringwald P.Antimicrob Agents Chemother. 2012 Dec 3. [Epub ahead of print]
• 8. Reduced artemisinin susceptibility of Plasmodium falciparum ring stages in western Cambodia.
  Witkowski B, Khim N, Chim P, Kim S, Ke S, Kloeung N, Chy S, Duong S, Leang R, Ringwald P, Dondorp AM, Tripura R, Benoit-Vical F, Berry A, Gorgette O, Ariey F, Barale JC, Mercereau-Puijalon O, Menard D.Antimicrob Agents Chemother. 2012 Dec 3. [Epub ahead of print]
• 9. Dihydroartemisinin inhibits the Bcr/Abl oncogene at the mRNA level in chronic myeloid leukemia sensitive or resistant to imatinib.
  Lee J, Shen P, Zhang G, Wu X, Zhang X.Biomed Pharmacother. 2012 Nov 19. doi:pii: S0753-3322(12)00109-6.  10.1016/j.biopha.2012.10.017. [Epub ahead of print]
• 10. Chemotherapeutic Strategies for Reducing Transmission of Plasmodium vivax Malaria.
  Douglas NM, John GK, von Seidlein L, Anstey NM, Price RN.Adv Parasitol. 2012;80:271-300. doi: 10.1016/B978-0-12-397900-1.00005-0.
• 11. A population pharmacokinetic model of piperaquine in pregnant and non-pregnant women with uncomplicated Plasmodium falciparum malaria in Sudan.
  Hoglund RM, Adam I, Hanpithakpong W, Ashton M, Lindegardh N, Day NP, White NJ, Nosten F, Tarning J.Malar J. 2012 Nov 29;11(1):398. [Epub ahead of print]
• 12. The effect of primaquine on gametocyte development and clearance in the treatment of uncomplicated falciparum malaria with dihydroartemisinin-piperaquine in South Sumatra, Western Indonesia: an open label randomized controlled trial.
  Sutanto I, Suprijanto S, Kosasih A, Dahlan MS, Sjafruddin D, Kusriastuti R, Hawley WA, Lobo NF, Ter Kuile FO.Clin Infect Dis. 2012 Nov 21. [Epub ahead of print]
• 13. Effect of high dose or split dose artesunate on parasite clearance in artemisinin resistant falciparum malaria.
  Das D, Tripura R, Phyo AP, Lwin KM, Tarning J, Lee SJ, Hanpithakpong W, Stepniewska K, Menard D, Ringwald P, Silamut K, Imwong M, Chotivanich K, Yi P, Day NP, Lindegardh N, Socheat D, Nguon C, White NJ, Nosten F, Dondorp AM.Clin Infect Dis. 2012 Nov 21. [Epub ahead of print]
• 14. Therapeutic efficacy of artemether-lumefantrine combination in the treatment of uncomplicated malaria among children under five years of age in three ecological zones in Ghana.
  Abuaku B, Duah N, Quaye L, Quashie N, Koram K.Malar J. 2012 Nov 22;11:388. doi: 10.1186/1475-2875-11-388.
• 15. An investigation of the auto-induction of and gender-related variability in the pharmacokinetics of dihydroartemisinin in the rat.
  Zhu F, Du F, Li X, Xing J.Malar J. 2012 Nov 21;11:379. doi: 10.1186/1475-2875-11-379.
• 16. Antimalarial activity of isoquine against Kenyan Plasmodium falciparum clinical isolates and association with polymorphisms in pfcrt and pfmdr1 genes.
  Okombo J, Kiara SM, Abdirahman A, Mwai L, Ohuma E, Borrmann S, Nzila A, Ward S.J Antimicrob Chemother. 2012 Nov 20. [Epub ahead of print]
• 17. Mechanism-based model of parasite growth and dihydroartemisinin pharmacodynamics in murine malaria.
  Patel K, Batty KT, Moore BR, Gibbons PL, Bulitta JB, Kirkpatrick CM.Antimicrob Agents Chemother. 2012 Nov 12. [Epub ahead of print]
• 18. Involvement of the mitochondrial pathway and Bim/Bcl-2 balance in dihydroartemisinin-induced             apoptosis in human breast cancer in vitro.
  Mao H, Gu H, Qu X, Sun J, Song B, Gao W, Liu J, Shao Q.Int J Mol Med. 2013 Jan;31(1):213-8. doi: 10.3892/ijmm.2012.1176. Epub 2012 Nov 8.
• 19. Induction of neurite outgrowth in PC12 cells by artemisinin through activation of ERK and p38 MAPK signaling pathways.
  Sarina, Yagi Y, Nakano O, Hashimoto T, Kimura K, Asakawa Y, Zhong M, Narimatsu S, Gohda E.Brain Res. 2012 Nov 2. doi:pii: S0006-8993(12)01749-0.  10.1016/j.brainres.2012.10.059. [Epub ahead of print]
• 20. Correction: Dihydroartemisinin Enhances Apo2L/TRAIL-Mediated Apoptosis in Pancreatic Cancer Cells via ROS-Mediated Up-Regulation of Death Receptor 5.
  Kong R, Jia G, Cheng ZX, Wang YW, Mu M, Wang SJ, Pan SH, Gao Y, Jiang HC, Dong DL, Sun B.PLoS One. 2012;7(10). doi: 10.1371/annotation/f7203563-87dc-4d11-a1b7-958f81cf743a. Epub 2012 Oct 11.

Details