Botanical Ingredient

Dioscin Safety Tips

Handling of Dioscin should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Dioscin’s antiviral effect in vitro.
  Liu C, Wang Y, Wu C, Pei R, Song J, Chen S, Chen X.Virus Res. 2012 Dec 10. doi:pii: S0168-1702(12)00463-7.  10.1016/j.virusres.2012.12.001. [Epub ahead of print]
• 2. Autophagy inhibition enhances apoptosis induced by dioscin in huh7 cells.
  Hsieh MJ, Yang SF, Hsieh YS, Chen TY, Chiou HL.Evid Based Complement Alternat Med. 2012;2012:134512. doi: 10.1155/2012/134512. Epub 2012 Nov 5.
• 3. Formulation and in vitro absorption analysis of Rhizoma paridis steroidal saponins.
  Liu Z, Wang J, Gao W, Man S, Guo H, Zhang J, Liu C.Int J Pharm. 2012 Oct 27. doi:pii: S0378-5173(12)00968-4.  10.1016/j.ijpharm.2012.10.028. [Epub ahead of print]
• 4. Dioscin: a synergistic tyrosinase inhibitor from the roots of Smilax china.
  Liang C, Lim JH, Kim SH, Kim DS.Food Chem. 2012 Sep 15;134(2):1146-8. doi: 10.1016/j.foodchem.2012.03.003. Epub 2012 Mar 7.
• 5. Dioscin, a natural steroid saponin, shows remarkable protective effect against acetaminophen-induced liver damage in vitro and in vivo.
  Zhao X, Cong X, Zheng L, Xu L, Yin L, Peng J.Toxicol Lett. 2012 Oct 2;214(1):69-80. doi: 10.1016/j.toxlet.2012.08.005. Epub 2012 Aug 21.
• 6. Dioscin sensitizes cells to TRAIL-induced apoptosis through downregulation of c-FLIP and Bcl-2.
  Kim YS, Kim EA, Park KG, Lee SJ, Kim MS, Sohn HY, Lee TJ.Oncol Rep. 2012 Nov;28(5):1910-6. doi: 10.3892/or.2012.1962. Epub 2012 Aug 9.
• 7. Natural products: a safest approach for obesity.
  Vasudeva N, Yadav N, Sharma SK.Chin J Integr Med. 2012 Jun;18(6):473-80. doi: 10.1007/s11655-012-1120-0. Epub 2012 Jul 22. Review.
• 8. A novel β-glucosidase from Aspergillus fumigates releases diosgenin from spirostanosides of Dioscorea zingiberensis C. H. Wright (DZW).
  Lei J, Niu H, Li T, Huang W.World J Microbiol Biotechnol. 2012 Mar;28(3):1309-14. doi: 10.1007/s11274-011-0907-z. Epub 2011 Nov 19.
• 9. Solanum incanum and S. heteracanthum as sources of biologically active steroid glycosides: confirmation of their synonymy.
  Manase MJ, Mitaine-Offer AC, Pertuit D, Miyamoto T, Tanaka C, Delemasure S, Dutartre P, Mirjolet JF, Duchamp O, Lacaille-Dubois MA.Fitoterapia. 2012 Sep;83(6):1115-9. doi: 10.1016/j.fitote.2012.04.024. Epub 2012 May 2.
• 10. Mechanism investigation of dioscin against CCl(4)-induced acute liver damage in mice.
  Lu B, Xu Y, Xu L, Cong X, Yin L, Li H, Peng J.Environ Toxicol Pharmacol. 2012 Sep;34(2):127-35. doi: 10.1016/j.etap.2012.03.010. Epub 2012 Mar 30.
• 11. Application of high-speed countercurrent chromatography-evaporative light scattering detection for the separation of seven steroidal saponins from Dioscorea villosa.
  Yoon KD, Chin YW, Yang MH, Choi J, Kim J.Phytochem Anal. 2012 Sep-Oct;23(5):462-8. doi: 10.1002/pca.2342. Epub 2012 Mar 9.
• 12. A 90-day subchronic toxicological assessment of dioscin, a natural steroid saponin, in Sprague-Dawley rats.
  Xu T, Zhang S, Zheng L, Yin L, Xu L, Peng J.Food Chem Toxicol. 2012 May;50(5):1279-87. doi: 10.1016/j.fct.2012.02.027. Epub 2012 Feb 22.
• 13. Cytotoxicity of dioscin in human gastric carcinoma cells through death receptor and mitochondrial pathways.
  Hu M, Xu L, Yin L, Qi Y, Li H, Xu Y, Han X, Peng J, Wan X.J Appl Toxicol. 2012 Feb 14. doi: 10.1002/jat.2715. [Epub ahead of print]
• 14. Absorption, disposition, and pharmacokinetics of saponins from Chinese medicinal herbs: what do we know and what do we need to know more?
  Yu K, Chen F, Li C.Curr Drug Metab. 2012 Jun 1;13(5):577-98. Review.
• 15. A high-throughput fluorescence resonance energy transfer (FRET)-based endothelial cell apoptosis assay and its application for screening vascular disrupting agents.
  Zhu X, Fu A, Luo KQ.Biochem Biophys Res Commun. 2012 Feb 24;418(4):641-6. doi: 10.1016/j.bbrc.2012.01.066. Epub 2012 Jan 21.
• 16. Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins.
  Wang Z, Cheng Y, Wang N, Wang DM, Li YW, Han F, Shen JG, Yang de P, Guan XY, Chen JP.Cancer Biol Ther. 2012 Feb 1;13(3):138-47. doi: 10.4161/cbt.13.3.18693. Epub 2012 Feb 1.
• 17. Paris chinensis dioscin induces G2/M cell cycle arrest and apoptosis in human gastric cancer SGC-7901 cells.
  Gao LL, Li FR, Jiao P, Yang MF, Zhou XJ, Si YH, Jiang WJ, Zheng TT.World J Gastroenterol. 2011 Oct 21;17(39):4389-95. doi: 10.3748/wjg.v17.i39.4389.
• 18. Saponins do not affect the ecdysteroid receptor complex but cause membrane permeation in insect culture cell lines.
  De Geyter E, Swevers L, Soin T, Geelen D, Smagghe G.J Insect Physiol. 2012 Jan;58(1):18-23. doi: 10.1016/j.jinsphys.2011.09.005. Epub 2011 Oct 25.
• 19. [Studies on the chemical constituents from the flowers of Ophiopogon japonicus].
  Zhu YH, Zhao M, Ren L, Tian D, Dou F, Wang JX.Zhong Yao Cai. 2011 May;34(5):720-3. Chinese.
• 20. Apoptosis of human ovarian cancer cells induced by Paris chinensis dioscin via a Ca(2+)-mediated mitochondrion pathway.
  Gao LL, Li FR, Jiao P, Yao ST, Sang H, Si YH.Asian Pac J Cancer Prev. 2011;12(5):1361-6.

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