Botanical Ingredient

Diosgenin Safety Tips

Handling of Diosgenin should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Diosgenin down-regulates NF-κB p65/p50 and p38MAPK pathways and attenuates acute lung injury induced by lipopolysaccharide in mice.
  Gao M, Chen L, Yu H, Sun Q, Kou J, Yu B.Int Immunopharmacol. 2012 Dec 13. doi:pii: S1567-5769(12)00362-1.  10.1016/j.intimp.2012.11.019. [Epub ahead of print]
• 2. Novel organic gelators based on pentose derivatized diosgenyl saponins.
  Guo X, Xin G, He S, Wang Y, Huang B, Zhao H, Xing Z, Chen Q, Huang W, He Y.Org Biomol Chem. 2012 Dec 12. [Epub ahead of print]
• 3. Diosgenin, a Steroidal Saponin, Exhibits Anticancer Activity by Attenuating Lipid Peroxidation Via Enhancing Antioxidant Defense System During NMU-Induced Breast Carcinoma.
  Jagadeesan J, Nandakumar N, Rengarajan T, Balasubramanian MP.J Environ Pathol Toxicol Oncol. 2012;31(2):121-9.
• 4. Preparation of nano/submicrometer yam and its benefits on collagen secretion from skin fibroblast cells.
  Chiang LH, Chen SH, Yeh AI.J Agric Food Chem. 2012 Dec 19;60(50):12332-40. doi: 10.1021/jf304036c. Epub 2012 Dec 11.
• 5. Synthesis, characterization and biological studies of diosgenyl analogues.
  Huang B, Du D, Zhang R, Wu X, Xing Z, He Y, Huang W.Bioorg Med Chem Lett. 2012 Dec 15;22(24):7330-4. doi: 10.1016/j.bmcl.2012.10.086. Epub 2012 Oct 23.
• 6. Synthesis and plant growth promoting activity of dinorcholanic lactones bearing the 5α-hydroxy-6-oxo moiety.
  Rosado-Abón A, de Dios-Bravo G, Rodríguez-Sotres R, Iglesias-Arteaga MA.J Steroid Biochem Mol Biol. 2013 Mar;134:45-50. doi: 10.1016/j.jsbmb.2012.10.007. Epub 2012 Oct 17.
• 7. Antineoplastic and apoptotic potential of traditional medicines thymoquinone and diosgenin in squamous cell carcinoma.
  Das S, Dey KK, Dey G, Pal I, Majumder A, MaitiChoudhury S, kundu SC, Mandal M.PLoS One. 2012;7(10):e46641. doi: 10.1371/journal.pone.0046641. Epub 2012 Oct 15.
• 8. N,O6-partially acetylated chitosan nanoparticles hydrophobically-modified for controlled release of steroids and vitamin E.
  Quiñones JP, Gothelf KV, Kjems J, Caballero ÁM, Schmidt C, Covas CP.Carbohydr Polym. 2013 Jan 2;91(1):143-51. doi: 10.1016/j.carbpol.2012.07.080. Epub 2012 Aug 10.
• 9. [Chemical constituents from aqueous extract of Gastrodia elata].
  Wang Y, Lin S, Chen M, Jiang B, Guo Q, Zhu C, Wang S, Yang Y, Shi J.Zhongguo Zhong Yao Za Zhi. 2012 Jun;37(12):1775-81. Chinese.
• 10. Preconditioning with diosgenin and treadmill exercise preserves the cardiac toxicity of isoproterenol in rats.
  Salimeh A, Mohammadi M, Rashidi B.J Physiol Biochem. 2012 Sep 6. [Epub ahead of print]
• 11. Dioscin, a natural steroid saponin, shows remarkable protective effect against acetaminophen-induced liver damage in vitro and in vivo.
  Zhao X, Cong X, Zheng L, Xu L, Yin L, Peng J.Toxicol Lett. 2012 Oct 2;214(1):69-80. doi: 10.1016/j.toxlet.2012.08.005. Epub 2012 Aug 21.
• 12. Carbohydrate-steroid conjugation by Ugi reaction: one-pot synthesis of triple sugar/pseudo-peptide/spirostane hybrids.
  Rivera DG, Pérez-Labrada K, Lambert L, Dörner S, Westermann B, Wessjohann LA.Carbohydr Res. 2012 Oct 1;359:102-10. doi: 10.1016/j.carres.2012.05.003. Epub 2012 May 11.
• 13. Diosgenin hemihydrate.
  Hernández Linares MG, Bernès S, Flores-Alamo M, Guerrero-Luna G, Martínez-Gallegos AA.Acta Crystallogr Sect E Struct Rep Online. 2012 Aug 1;68(Pt 8):o2357. doi: 10.1107/S1600536812027912. Epub 2012 Jul 7.
• 14. Anticlastogenic effect of diosgenin on 7,12-dimethylbenz(a)anthracene treated experimental animals.
  Rajalingam K, Sugunadevi G, Vijayaanand MA, Sathiyapriya J, Sivakumar K, Suresh K.Toxicol Mech Methods. 2012 Oct 3. [Epub ahead of print]
• 15. Molluscicidal activity of Balanites aegyptiaca against Monacha cartusiana.
  Dawidar AE, Mortada MM, Raghib HM, Abdel-Mogib M.Pharm Biol. 2012 Oct;50(10):1326-9. doi: 10.3109/13880209.2012.674950. Epub 2012 Aug 14.
• 16. Diosgenin is an exogenous activator of 1,25D?-MARRS/Pdia3/ERp57 and improves Alzheimer’s disease pathologies in 5XFAD mice.
  Tohda C, Urano T, Umezaki M, Nemere I, Kuboyama T.Sci Rep. 2012;2:535. doi: 10.1038/srep00535. Epub 2012 Jul 26.
• 17. A novel β-glucosidase from Aspergillus fumigates releases diosgenin from spirostanosides of Dioscorea zingiberensis C. H. Wright (DZW).
  Lei J, Niu H, Li T, Huang W.World J Microbiol Biotechnol. 2012 Mar;28(3):1309-14. doi: 10.1007/s11274-011-0907-z. Epub 2011 Nov 19.
• 18. [Novel derivatives of diosgenin: design, synthesis and anti-tumor activity].
  Ding XY, He G, Jiang HP, Wan JF, Fan JZ.Yao Xue Xue Bao. 2012 Apr;47(4):479-85. Chinese.
• 19. Beneficial role of diosgenin on oxidative stress in aorta of streptozotocin induced diabetic rats.
  Pari L, Monisha P, Mohamed Jalaludeen A.Eur J Pharmacol. 2012 Sep 15;691(1-3):143-50. doi: 10.1016/j.ejphar.2012.06.038. Epub 2012 Jul 4.
• 20. Synthesis and selective anticancer activity of steroidal glycoconjugates.
  Fernández-Herrera MA, López-Muñoz H, Hernández-Vázquez JM, Sánchez-Sánchez L, Escobar-Sánchez ML, Pinto BM, Sandoval-Ramírez J.Eur J Med Chem. 2012 Aug;54:721-7. doi: 10.1016/j.ejmech.2012.06.027. Epub 2012 Jun 21.

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