Botanical Ingredient

Diosmin Safety Tips

Handling of Diosmin should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Enhancement of the Water Solubility of Flavone Glycosides by Disruption of Molecular Planarity of the Aglycone Moiety.
  Lewin G, Maciuk A, Moncomble A, Cornard JP.J Nat Prod. 2012 Dec 18. [Epub ahead of print]
• 2. [Flavonoid glycosides from dried and nearly ripe fruits of Evodia rutaecarpa].
  Hu CQ, Yang XB, Yang XW, Liu JX.Zhongguo Zhong Yao Za Zhi. 2012 Sep;37(17):2571-5. Chinese.
• 3. Chemical fingerprinting by RP-RRLC-DAD and principal component analysis of Ziziphora clinopodioides from different locations.
  Tiana S, Yu Q, Xin L, Zhou ZS, Upur H.Nat Prod Commun. 2012 Sep;7(9):1181-4.
• 4. [On advisability of perioperative phleboprotection in endovascular treatment of lower in varicose disease: first initial results of the decision study].
  Bogachev VIu, Golovanova OV, Kuzhetsov AN, Shekoian AO.Angiol Sosud Khir. 2012;18(2):90-5. Russian.
• 5. Phlebotonics for haemorrhoids.
  Perera N, Liolitsa D, Iype S, Croxford A, Yassin M, Lang P, Ukaegbu O, van Issum C.Cochrane Database Syst Rev. 2012 Aug 15;8:CD004322. doi: 10.1002/14651858.CD004322.pub3. Review.
• 6. [Micronized purified flavonoid fraction in treatment of pelvic varicose veins].
  Gavrilov SG, Karalkin AV, Moskalenko EP, Beliaeva ES, Ianina AM, Kirienko AI.Angiol Sosud Khir. 2012;18(1):71-5. Russian.
• 7. Meta-analysis of the impact of the principal venoactive drugs agents on malleolar venous edema.
  Allaert FA.Int Angiol. 2012 Aug;31(4):310-5. Review.
• 8. [Chemical constituents contained in seeds of Notopterygium franchetii].
  Zhang Y, Jiang S, Xu K, Shi H, Zhou Y, Deng W, Ding L, Peng S.Zhongguo Zhong Yao Za Zhi. 2012 Apr;37(7):941-5. Chinese.
• 9. Diosmin protects rat retina from ischemia/reperfusion injury.
  Tong N, Zhang Z, Gong Y, Yin L, Wu X.J Ocul Pharmacol Ther. 2012 Oct;28(5):459-66. Epub 2012 Apr 17.
• 10. Pharmacologic and compression therapies for postthrombotic syndrome: a systematic review of randomized controlled trials.
  Cohen JM, Akl EA, Kahn SR.Chest. 2012 Feb;141(2):308-20. doi: 10.1378/chest.11-1175. Review.
• 11. PP2A mediates diosmin p53 activation to block HA22T cell proliferation and tumor growth in xenografted nude mice through PI3K-Akt-MDM2 signaling suppression.
  Dung TD, Day CH, Binh TV, Lin CH, Hsu HH, Su CC, Lin YM, Tsai FJ, Kuo WW, Chen LM, Huang CY.Food Chem Toxicol. 2012 May;50(5):1802-10. doi: 10.1016/j.fct.2012.01.021. Epub 2012 Jan 25.
• 12. Diosmin, a bioflavonoid reverses alterations in blood pressure, nitric oxide, lipid peroxides and antioxidant status in DOCA-salt induced hypertensive rats.
  Silambarasan T, Raja B.Eur J Pharmacol. 2012 Mar 15;679(1-3):81-9. doi: 10.1016/j.ejphar.2011.12.040. Epub 2012 Jan 12.
• 13. Clinical effectiveness of a highly standardized and bioavailable mixture of flavonoids and triterpenes in the management of acute hemorroidal crisis.
  Di Pierro F, Spinelli G, Monsù G, Alvisi G, Bacci G, Baiocchi C, Buratta M, Martinoli A, Vitali F, Agrifoglio C, Gennaioli F, Lucarelli M.Acta Biomed. 2011 Apr;82(1):35-40.
• 14. Ameliorative effect of diosmin, a citrus flavonoid against streptozotocin-nicotinamide generated oxidative stress induced diabetic rats.
  Srinivasan S, Pari L.Chem Biol Interact. 2012 Jan 5;195(1):43-51. doi: 10.1016/j.cbi.2011.10.003. Epub 2011 Oct 28.
• 15. Diosmin ameliorates intestinal injury induced by hepatic ischemia reperfusion in rats.
  Tanrikulu Y, Kismet K, Serin Kilicoglu S, Devrim E, Erel S, Sen Tanrikulu C, Dinc S, Edebal OH, Erdemli E, Akkus MA.Bratisl Lek Listy. 2011;112(10):545-51.
• 16. Antioxidant therapy: current status and future prospects.
  Firuzi O, Miri R, Tavakkoli M, Saso L.Curr Med Chem. 2011;18(25):3871-88. Review.
• 17. The effect of a flavonoid fractions diosmin + hesperidin on radiation-induced acute proctitis in a rat model.
  Sezer A, Usta U, Kocak Z, Yagci MA.J Cancer Res Ther. 2011 Apr-Jun;7(2):152-6. doi: 10.4103/0973-1482.82927.
• 18. Chemical genoprotection: reducing biological damage to as low as reasonably achievable levels.
  Alcaraz M, Armero D, Martínez-Beneyto Y, Castillo J, Benavente-García O, Fernandez H, Alcaraz-Saura M, Canteras M.Dentomaxillofac Radiol. 2011 Jul;40(5):310-4. doi: 10.1259/dmfr/95408354.
• 19. HPLC determination of hesperidin, diosmin and eriocitrin in Iranian lime juice using polyamide as an adsorbent for solid phase extraction.
  Saeidi I, Hadjmohammadi MR, Peyrovi M, Iranshahi M, Barfi B, Babaei AB, Dust AM.J Pharm Biomed Anal. 2011 Sep 10;56(2):419-22. doi: 10.1016/j.jpba.2011.05.015. Epub 2011 May 20.
• 20. Ca(2+)-dependent contraction by the saponoside escin in rat vena cava: implications in venotonic treatment of varicose veins.
  Raffetto JD, Khalil RA.J Vasc Surg. 2011 Aug;54(2):489-96. doi: 10.1016/j.jvs.2011.01.043. Epub 2011 Apr 16.

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