Botanical Ingredient

Emodin Safety Tips

Handling of Emodin should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Emodin Improves Lipopolysaccharide-Induced Microcirculatory Disturbance in Rat Mesentery.
  Li A, et al. Microcirculation. 2013. [Epub ahead of Print].
• 2. Anthraquinone emodin inhibits human cancer cell invasiveness by antagonizing P2X7 receptors
  Jelassi B, et al. Carcinogenesis. 2013. [Epub ahead of Print].
• 3. Stilbene glucoside inhibits the glucuronidation of emodin in rats through the down-regulation of UDP-glucuronosyltransferases 1A8: Application to a drug-drug interaction study in Radix Polygoni Multiflori
  Ma J, et al. J Ethnopharmacol. 2013. [Epub ahead of Print].
• 4. Emodin ameliorates lipopolysaccharide-induced mastitis in mice by inhibiting activation of NF-kB and MAPKs signal pathways
  Li D, et al. Eur J Pharmacol. 2013. [Epub ahead of Print].
• 5. Synthesis of emodin derivatives and their inhibiting effects on proliferation of leukemia cell lines
  Zheng JT, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2013. [Epub ahead of Print].
• 6. [New method of processing on Rhei Radix Et Rhizoma and study on quality control of its processing products].
  Wang ZS, Han GR, Gao F, An LN, Ji YZ.Zhong Yao Cai. 2012 May;35(5):699-702. Chinese.
• 7. Exploration of effects of emodin in selected cancer cell lines: enhanced growth inhibition by ascorbic acid and regulation of LRP1 and AR under hypoxia-like conditions.
  Masaldan S, Iyer VV.J Appl Toxicol. 2012 Dec 5. doi: 10.1002/jat.2838. [Epub ahead of print]
• 8. The Influence of Rhein 8-O-β-D-Glucopyranoside on the Purgative Action of Sennoside A from Rhubarb in Mice.
  Takayama K, Tsutsumi H, Ishizu T, Okamura N.Biol Pharm Bull. 2012;35(12):2204-8.
• 9. Injurious Effects of Emodin on Maturation of Mouse Oocytes, Fertilization and Fetal Development via Apoptosis.
  Chang MH, Chang SC, Chan WH.Int J Mol Sci. 2012 Oct 29;13(11):13911-25. doi: 10.3390/ijms131113911.
• 10. Comparative Pharmacokinetics of Five Rhubarb Anthraquinones in Normal and Thrombotic Focal Cerebral Ischemia-Induced Rats.
  Feng SX, Li JS, Qu LB, Shi YM, Zhao D.Phytother Res. 2012 Nov 26. doi: 10.1002/ptr.4890. [Epub ahead of print]
• 11. Anti-inflammatory properties of anthraquinones and their relationship with the regulation of P-glycoprotein function and expression.
  Choi RJ, Ngoc TM, Bae K, Cho HJ, Kim DD, Chun J, Khan S, Kim YS.Eur J Pharm Sci. 2012 Nov 19;48(1-2):272-281. doi: 10.1016/j.ejps.2012.10.027. [Epub ahead of print]
• 12. Detection of active P-glycoprotein in systemic lupus erythematosus patients with poor disease control.
  Zhang B, Shi Y, Lei TC.Exp Ther Med. 2012 Oct;4(4):705-710. Epub 2012 Aug 16.
• 13. Emodin-6-O-β-d-glucoside inhibits HMGB1-induced inflammatory responses in vitro and in vivo.
  Lee W, Ku SK, Kim TH, Bae JS.Food Chem Toxicol. 2012 Nov 9;52C:97-104. doi: 10.1016/j.fct.2012.10.061. [Epub ahead of print]
• 14. Anti-inflammatory activity of a novel family of aryl ureas compounds in an endotoxin-induced airway epithelial cell injury model.
  Cabrera-Benitez NE, Pérez-Roth E, Casula M, Ramos-Nuez A, Ríos-Luci C, Rodríguez-Gallego C, Sologuren I, Jakubkiene V, Slutsky AS, Padrón JM, Villar J.PLoS One. 2012;7(11):e48468. doi: 10.1371/journal.pone.0048468. Epub 2012 Nov 8.
• 15. Bioactive anthraquinones from endophytic fungus Aspergillus versicolor isolated from red sea algae.
  Hawas UW, El-Beih AA, El-Halawany AM.Arch Pharm Res. 2012 Oct;35(10):1749-56. doi: 10.1007/s12272-012-1006-x. Epub 2012 Nov 9.
• 16. Effect of acute pancreatitis on the pharmacokinetics of Chinese herbal ointment Liu-He-Dan in anaesthetized rats.
  Zhao XL, Xiang J, Wan MH, Yu Q, Chen WW, Chen GY, Tang WF.J Ethnopharmacol. 2012 Nov 2. doi:pii: S0378-8741(12)00733-7.  10.1016/j.jep.2012.10.036. [Epub ahead of print]
• 17. Anthraquinone profile, antioxidant and antimicrobial activity of bark extracts of Rhamnus alaternus, R. fallax, R. intermedia and R. pumila.
  Kosalec I, Kremer D, Locatelli M, Epifano F, Genovese S, Carlucci G, Randi? M, Zovko Kon?i? M.Food Chem. 2013 Jan 15;136(2):335-41. doi: 10.1016/j.foodchem.2012.08.026. Epub 2012 Aug 23.
• 18. Study on Spectrum-Effect Relationship of Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Aurantii Immaturus and their Formula.
  Xie RF, Zhou X, Shi ZN, Li YM, Li ZC.J Chromatogr Sci. 2012 Oct 31. [Epub ahead of print]
• 19. Chemical constituents of Arisaema franchetianum tubers.
  Su Y, Xu JJ, Bi JL, Wang YH, Hu GW, Yang J, Yin GF, Long CL.J Asian Nat Prod Res. 2012 Oct 29. [Epub ahead of print]
• 20. The analytical application and spectral investigation of DNA-CPB-emodin and sensitive determination of DNA by resonance Rayleigh light scattering technique.
  Bi S, Wang Y, Wang T, Pang B, Zhao T.Spectrochim Acta A Mol Biomol Spectrosc. 2013 Jan 15;101:233-8. doi: 10.1016/j.saa.2012.09.088. Epub 2012 Oct 5.

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