Botanical Ingredient

Escin Safety Tips

Handling of Escin should only be performed by personnel trained and familiar with the handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Escin Inhibits Type I Allergic Dermatitis in a Novel Porcine Model.
  Sipos W, Reutterer B, Frank M, Unger H, Grassauer A, Prieschl-Grassauer E, Doerfler P.Int Arch Allergy Immunol. 2012 Dec 14;161(1):44-52. [Epub ahead of print]
• 2. Interaction Between Titanium and Cadmium in Various Guinea Pig Organs.
  Takano T, Kaneda T, Kaneshige M, Tsutsumi T, Ochiai Y, Shimizu K, Hondo R, Mochizuki M, Ueda F.Biol Trace Elem Res. 2012 Dec 13. [Epub ahead of print]
• 3. Potent anti-inflammatory agent escin does not affect the healing of tibia fracture and abdominal wound in an animal model.
  Zhang L, Wang H, Wang T, Jiang N, Yu P, Liu F, Chong Y, Fu F.Exp Ther Med. 2012 Apr;3(4):735-739. Epub 2012 Jan 31.
• 4. Use of Escin as a Perforating Agent on the IonWorks Quattro Automated Electrophysiology Platform.
  Morton MJ, Main MJ.J Biomol Screen. 2012 Aug 24. [Epub ahead of print]
• 5. The Apoptotic Effects of Escin in The H-Ras Transformed 5RP7 Cell Line.
  Güney G, Kutlu HM, I?can A.Phytother Res. 2012 Aug 21. doi: 10.1002/ptr.4804. [Epub ahead of print]
• 6. Escin inhibits lipopolysaccharide-induced inflammation in human periodontal ligament cells.
  Liu S, Wang H, Qiu C, Zhang J, Zhang T, Zhou W, Lu Z, Rausch-Fan X, Liu Z.Mol Med Report. 2012 Nov;6(5):1150-4. doi: 10.3892/mmr.2012.1031. Epub 2012 Aug 10.
• 7. [Application of recording SK2 current in human atrial myocytes by perforated patch clamp techniques with the mix of beta-escin and amphotericin B].
  Wang H, Li T, Lei M, Li ML, Ding YY, Yang Y, Zeng XR.Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2012 May;28(3):214-8. Chinese.
• 8. Caffeine relaxes smooth muscle through actin depolymerization.
  Tazzeo T, Bates G, Roman HN, Lauzon AM, Khasnis MD, Eto M, Janssen LJ.Am J Physiol Lung Cell Mol Physiol. 2012 Aug 15;303(4):L334-42. doi: 10.1152/ajplung.00103.2012. Epub 2012 Jun 8.
• 9. Biophysical and pharmacological properties of glucagon-like peptide-1 in rats under isoflurane anesthesia.
  Kawano T, Tanaka K, Chi H, Eguchi S, Yamazaki F, Kitamura S, Kumagai N, Yokoyama M.Anesth Analg. 2012 Jul;115(1):62-9. doi: 10.1213/ANE.0b013e318253cbf0. Epub 2012 Apr 13.
• 10. Escin augments the efficacy of gemcitabine through the down-regulation of nuclear factor-κB and nuclear factor-κB-regulated gene products in pancreatic cancer both in vitro and in vivo.
  Wang YW, Wang SJ, Zhou YN, Pan SH, Sun B.J Cancer Res Clin Oncol. 2012 May;138(5):785-97. doi: 10.1007/s00432-012-1152-z. Epub 2012 Jan 24.
• 11. Aescin: microcirculatory activity. Effects of accessory components on clinical and microcirculatory efficacy.
  Luzzi R, Feragalli B, Belcaro G, Cesarone MR, Cornelli U, Dugall M, Hosoi M.Panminerva Med. 2011 Sep;53(3 Suppl 1):51-5.
• 12. Comparative pharmacokinetics and bioavailability of escin Ia and isoescin Ia after administration of escin and of pure escin Ia and isoescin Ia in rat.
  Wu XJ, Zhang ML, Cui XY, Gao F, He Q, Li XJ, Zhang JW, Fawcett JP, Gu JK.J Ethnopharmacol. 2012 Jan 6;139(1):201-6. doi: 10.1016/j.jep.2011.11.003. Epub 2011 Nov 10.
• 13. The impact of sodium aescinate on acute lung injury induced by oleic acid in rats.
  Wei T, Tong W, Wen-ping S, Xiao-hui D, Qiang X, Tian-shui L, Zhi-fang C, Hong-fang J, Li N, Bin Z, Jun-bao D, Bao-ming G.Exp Lung Res. 2011 Dec;37(10):585-99. doi: 10.3109/01902148.2011.622426.
• 14. Intracellular drug delivery in Leishmania-infected macrophages: Evaluation of saponin-loaded PLGA nanoparticles.
  Van de Ven H, Vermeersch M, Vandenbroucke RE, Matheeussen A, Apers S, Weyenberg W, De Smedt SC, Cos P, Maes L, Ludwig A.J Drug Target. 2012 Feb;20(2):142-54. doi: 10.3109/1061186X.2011.595491. Epub 2011 Nov 14.
• 15. The antinociceptive effect of intrathecal escin in the rat formalin test.
  Li Q, Ouyang H, Wang P, Zeng W.Eur J Pharmacol. 2012 Jan 15;674(2-3):234-8. doi: 10.1016/j.ejphar.2011.10.025. Epub 2011 Oct 26.
• 16. Mixture designs in the optimisation of PLGA nanoparticles: influence of organic phase composition on β-aescin encapsulation.
  Ven HV, Vandervoort J, Weyenberg W, Apers S, Ludwig A.J Microencapsul. 2012;29(2):115-25. doi: 10.3109/02652048.2011.630108. Epub 2011 Nov 2.
• 17. Synchronous phosphorylation of CPI-17 and MYPT1 is essential for inducing Ca(2+)  sensitization in intestinal smooth muscle.
  Mori D, Hori M, Murata T, Ohama T, Kishi H, Kobayashi S, Ozaki H.Neurogastroenterol Motil. 2011 Dec;23(12):1111-22. doi: 10.1111/j.1365-2982.2011.01799.x. Epub 2011 Oct 17.
• 18. 3′,4′-Dihydroxyflavonol reduces vascular contraction through Ca²? desensitization in permeabilized rat mesenteric artery.
  Kim HY, Seok YM, Woodman OL, Williams SJ, Kim IK.Naunyn Schmiedebergs Arch Pharmacol. 2012 Feb;385(2):191-202. doi: 10.1007/s00210-011-0697-8. Epub 2011 Oct 14.
• 19. Synergistic interactions of saponins and monoterpenes in HeLa cells, Cos7 cells and in erythrocytes.
  Herrmann F, Wink M.Phytomedicine. 2011 Oct 15;18(13):1191-6. doi: 10.1016/j.phymed.2011.08.070. Epub 2011 Oct 2.
• 20. PLGA nanoparticles loaded with the antileishmanial saponin β-aescin: factor influence study and in vitro efficacy evaluation.
  Van de Ven H, Vermeersch M, Matheeussen A, Vandervoort J, Weyenberg W, Apers S, Cos P, Maes L, Ludwig A.Int J Pharm. 2011 Nov 25;420(1):122-32. doi: 10.1016/j.ijpharm.2011.08.016. Epub 2011 Aug 16.

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