Standard Herbal Extract

Eucommia Ulmoides Extract Safety Tips

Handling of Eucommia Ulmoides Extract should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Epimedium koreanum Nakai Water Extract Exhibits Antiviral Activity against Porcine Epidermic Diarrhea Virus In Vitro and In Vivo.
  Cho WK, Kim H, Choi YJ, Yim NH, Yang HJ, Ma JY.Evid Based Complement Alternat Med. 2012;2012:985151. doi: 10.1155/2012/985151. Epub 2012 Nov 29.
• 2. [Analysis of the osteogenetic effects exerted on mesenchymal stem cell strain C3H10T1/2 by icariin via MAPK signaling pathway in vitro].
  Mao XY, Bian Q, Shen ZY.Zhong Xi Yi Jie He Xue Bao. 2012 Nov;10(11):1272-8. Chinese.
• 3. Epimedium koreanum Extract and Its Constituent Icariin Improve Motor Dysfunction in Spinal Cord Injury.
  Tohda C, Nagata A.Evid Based Complement Alternat Med. 2012;2012:731208. doi: 10.1155/2012/731208. Epub 2012 Aug 23.
• 4. [Comparative study on chemical quality of main species of epimedium].
  Han S, Xie YY, Wang YM, Liang QL, Luo GA.Yao Xue Xue Bao. 2012 Apr;47(4):502-7. Chinese.
• 5. High-performance liquid chromatography-based multivariate analysis to predict the estrogenic activity of an Epimedium koreanum extract.
  Islam MN, Kim U, Kim DH, Dong MS, Yoo HH.Biosci Biotechnol Biochem. 2012;76(5):923-7. Epub 2012 May 7.
• 6. A combination extract of ginseng, epimedium, polygala, and tuber curcumae increases synaptophysin expression in APPV717I transgenic mice.
  Shi J, Tian J, Zhang X, Wei M, Yin L, Wang P, Wang Y.Chin Med. 2012 Jun 9;7(1):13. doi: 10.1186/1749-8546-7-13.
• 7. Estrogenic/antiestrogenic activities of a Epimedium koreanum extract and its major components: in vitro and in vivo studies.
  Kang HK, Choi YH, Kwon H, Lee SB, Kim DH, Sung CK, Park YI, Dong MS.Food Chem Toxicol. 2012 Aug;50(8):2751-9. doi: 10.1016/j.fct.2012.05.017. Epub 2012 May 18.
• 8. Acylated flavonol glycosides from Epimedium elatum, a plant endemic to the Western Himalayas.
  Tantry MA, Dar JA, Idris A, Akbar S, Shawl AS.Fitoterapia. 2012 Jun;83(4):665-70. doi: 10.1016/j.fitote.2012.02.003. Epub 2012 Feb 18.
• 9. [Preparation of flavonol glycoside reference standard series from Epimedium brevicornum Maxim using pilot-scale preparative high performance liquid chromatography].
  Gao M, Wang L, Peng J, Xiao H.Se Pu. 2011 Sep;29(9):932-6. Chinese.
• 10. [Effect of epimedium extract on osteoprotegerin and RANKL mRNA expressions in glucocorticoid-induced femoral head necrosis in rats].
  Wang JZ, Gao HY, Wang KZ, Zhou RX, Li XD, Guo J, Lv HC.Nan Fang Yi Ke Da Xue Xue Bao. 2011 Oct;31(10):1714-7. Chinese.
• 11. Antiinflammatory effects of Epimedium brevicornum water extract on lipopolysaccharide-activated RAW264.7 macrophages.
  Yuk SS, Lim EM, Lee JY, Lee YJ, Kim YS, Lee TH, Park SK, Bae H, Kim HM, Ko SG, Oh MS, Park W.Phytother Res. 2010 Dec;24(12):1781-7. doi: 10.1002/ptr.3161.
• 12. Erectogenic and neurotrophic effects of icariin, a purified extract of horny goat weed (Epimedium spp.) in vitro and in vivo.
  Shindel AW, Xin ZC, Lin G, Fandel TM, Huang YC, Banie L, Breyer BN, Garcia MM, Lin CS, Lue TF.J Sex Med. 2010 Apr;7(4 Pt 1):1518-28. doi: 10.1111/j.1743-6109.2009.01699.x. Epub 2010 Feb 5.
• 13. Two new flavonol glycosides from Epimedium koreanum Nakai.
  Jiang F, Wang XL, Wang NL, Yao XS.J Asian Nat Prod Res. 2009;11(5):401-9. doi: 10.1080/10286020902867151.
• 14. Pharmacokinetics of prenylflavonoids and correlations with the dynamics of estrogen action in sera following ingestion of a standardized Epimedium extract.
  Wong SP, Shen P, Lee L, Li J, Yong EL.J Pharm Biomed Anal. 2009 Sep 8;50(2):216-23. doi: 10.1016/j.jpba.2009.04.022. Epub 2009 May 3.
• 15. Potent inhibition of human phosphodiesterase-5 by icariin derivatives.
  Dell’Agli M, Galli GV, Dal Cero E, Belluti F, Matera R, Zironi E, Pagliuca G, Bosisio E.J Nat Prod. 2008 Sep;71(9):1513-7. doi: 10.1021/np800049y. Epub 2008 Sep 9.
• 16. Identification and characterization of active compounds and their metabolites by high-performance liquid chromatography/Fourier transform ion cyclotron resonance mass spectrometry after oral administration of a herbal extract of Epimedium koreanum Nakai to rats.
  Wu C, Sheng Y, Zhang Y, Zhang J, Guo B.Rapid Commun Mass Spectrom. 2008 Sep;22(18):2813-24. doi: 10.1002/rcm.3664.
• 17. [Effects of rat serum containing total flavonoid extract of Epimedium sagittatum on development of osteoblasts].
  Ma HP, Jia ZP, Cheng KM, Zhang RX, Li MX, Wang J.Zhongguo Zhong Yao Za Zhi. 2008 Apr;33(8):928-31. Chinese.
• 18. Determination of icariin in rat plasma by reverse-phase high-performance liquid chromatography after oral administration of a lipid-based suspension of Epimedium koreanum extract.
  Pozharitskaya ON, Karlina MV, Shikov AN, Kosman VM, Makarova MN, Makarov VG.Biomed Chromatogr. 2008 Jun;22(6):625-9. doi: 10.1002/bmc.978.
• 19. Icariin enhances the osteogenic differentiation of bone marrow stromal cells but has no effects on the differentiation of newborn calvarial osteoblasts of rats.
  Chen KM, Ma HP, Ge BF, Liu XY, Ma LP, Bai MH, Wang Y.Pharmazie. 2007 Oct;62(10):785-9.
• 20. Antifatigue effect of Rubus coreanus Miquel extract in mice.
  Jung KA, Han D, Kwon EK, Lee CH, Kim YE.J Med Food. 2007 Dec;10(4):689-93.

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