Botanical Ingredient

Formononetin Safety Tips

Handling of Formononetin should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Analysis and retention behavior of isoflavone glycosides and aglycones in Radix Astragali by HPLC with hydroxypropyl-β-cyclodextrin as a mobile phase additive.
  Feng B, Jin J, Wang C, Song J, Yang G, Zeng A.J Sep Sci. 2012 Dec;35(24):3469-76. doi: 10.1002/jssc.201200389. Epub 2012 Nov 20.
• 2. A modified QuEChERS method as sample treatment before the determination of isoflavones in foods by ultra-performance liquid chromatography-triple quadrupole mass spectrometry.
  Delgado-Zamarreño MM, Pérez-Martín L, Bustamante-Rangel M, Carabias-Martínez R.Talanta. 2012 Oct 15;100:320-8. doi: 10.1016/j.talanta.2012.07.070. Epub 2012 Aug 16.
• 3. Antihypertensive effect of formononetin through regulating the expressions of eNOS, 5-HT(2A/1B) receptors and α(1)-adrenoceptors in spontaneously hypertensive rat arteries.
  Sun T, Wang J, Huang LH, Cao YX.Eur J Pharmacol. 2012 Oct 30. doi:pii: S0014-2999(12)00899-0.  10.1016/j.ejphar.2012.10.031. [Epub ahead of print]
• 4. Comparative Analysis of the Main Bioactive Components of San-ao Decoction and Its Series of Formulations.
  Shu X, Tang Y, Jiang C, Shang E, Fan X, Ding A.Molecules. 2012 Nov 1;17(11):12925-37. doi: 10.3390/molecules171112925.
• 5. Novel anti-angiogenic effects of formononetin in human colon cancer cells and tumor xenograft.
  Auyeung KK, Law PC, Ko JK.Oncol Rep. 2012 Dec;28(6):2188-94. doi: 10.3892/or.2012.2056. Epub 2012 Sep 26.
• 6. Influence of arbuscular mycorrhizal colonisation on cadmium-induced Medicago truncatula root isoflavonoid accumulation.
  Aloui A, Dumas-Gaudot E, Daher Z, van Tuinen D, Aschi-Smit S, Morandi D.Plant Physiol Biochem. 2012 Nov;60:233-9. doi: 10.1016/j.plaphy.2012.08.014. Epub 2012 Sep 5.
• 7. HPLC-MS/MS analysis of a traditional Chinese medical formulation of Bu-Yang-Huan-Wu-Tang and its pharmacokinetics after oral administration to rats.
  Shaw LH, Lin LC, Tsai TH.PLoS One. 2012;7(8):e43848. doi: 10.1371/journal.pone.0043848. Epub 2012 Aug 29.
• 8. Distribution of isoflavones and coumestrol in neglected tropical and subtropical legumes.
  Leuner O, Havlik J, Hummelova J, Prokudina E, Novy P, Kokoska L.J Sci Food Agric. 2012 Aug 28. doi: 10.1002/jsfa.5835. [Epub ahead of print]
• 9. Formononetin attenuates IL-1β-induced apoptosis and NF-κB activation in INS-1 cells.
  Wang Y, Zhu Y, Gao L, Yin H, Xie Z, Wang D, Zhu Z, Han X.Molecules. 2012 Aug 24;17(9):10052-64. doi: 10.3390/molecules170910052.
• 10. Expression and functional characterization of a white clover isoflavone synthase in tobacco.
  Franzmayr BK, Rasmussen S, Fraser KM, Jameson PE.Ann Bot. 2012 Nov;110(6):1291-301. doi: 10.1093/aob/mcs168. Epub 2012 Aug 22.
• 11. Chemical and biological assessment of Angelica herbal decoction: comparison of different preparations during historical applications.
  Zhang WL, Zheng KY, Zhu KY, Zhan JY, Bi CW, Chen JP, Du CY, Zhao KJ, Lau DT, Dong TT, Tsim KW.Phytomedicine. 2012 Aug 15;19(11):1042-8. doi: 10.1016/j.phymed.2012.07.009. Epub 2012 Aug 16.
• 12. Formononetin-induced Apoptosis by Activation of Ras/p38 Mitogen-activated Protein Kinase in Estrogen Receptor-positive Human Breast Cancer Cells.
  Chen J, Sun L.Horm Metab Res. 2012 Dec;44(13):943-8. doi: 10.1055/s-0032-1321818. Epub 2012 Jul 24.
• 13. The bone-promoting actions of formononetin in established osteopenia.
  Pru JK.Menopause. 2012 Aug;19(8):843-4. doi: 10.1097/gme.0b013e31825e9be3. No abstract available.
• 14. Effects of feeding dairy cows different legume-grass silages on milk phytoestrogen concentration.
  Höjer A, Adler S, Purup S, Hansen-Møller J, Martinsson K, Steinshamn H, Gustavsson AM.J Dairy Sci. 2012 Aug;95(8):4526-40. doi: 10.3168/jds.2011-5226.
• 15. Germination dramatically increases isoflavonoid content and diversity in chickpea (Cicer arietinum L.) seeds.
  Wu Z, Song L, Feng S, Liu Y, He G, Yioe Y, Liu SQ, Huang D.J Agric Food Chem. 2012 Sep 5;60(35):8606-15. doi: 10.1021/jf3021514. Epub 2012 Aug 15.
• 16. Formononetin reverses established osteopenia in adult ovariectomized rats.
  Tyagi AM, Srivastava K, Singh AK, Kumar A, Changkija B, Pandey R, Lahiri S, Nagar GK, Yadav DK, Maurya R, Trivedi R, Singh D.Menopause. 2012 Aug;19(8):856-63. doi: 10.1097/gme.0b013e31824f9306.
• 17. Profiling and identification of the metabolites of calycosin in rat hepatic 9000×g supernatant incubation system and the metabolites of calycosin-7-O-β-D-glucoside in rat urine by HPLC-DAD-ESI-IT-TOF-MS(n) technique.
  Zhang YZ, Xu F, Dong J, Liang J, Hashi Y, Shang MY, Yang DH, Wang X, Cai SQ.J Pharm Biomed Anal. 2012 Nov;70:425-39. doi: 10.1016/j.jpba.2012.06.006. Epub 2012 Jun 12.
• 18. The isolation of bioactive flavonoids from Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry.
  Khamsan S, Liawruangrath S, Teerawutkulrag A, Pyne SG, Garson MJ, Liawruangrath B.Acta Pharm. 2012 Jun 1;62(2):181-90. doi: 10.2478/v10007-012-0014-1.
• 19. Metabolomics-based optimal koji fermentation for tyrosinase inhibition supplemented with Astragalus radix.
  Kim AJ, Choi JN, Kim J, Yeo SH, Choi JH, Lee CH.Biosci Biotechnol Biochem. 2012;76(5):863-9. Epub 2012 May 7.
• 20. The membrane permeability of Astragali Radix-derived formononetin and calycosin is increased by Angelicae Sinensis Radix in Caco-2 cells: a synergistic action of an ancient herbal decoction Danggui Buxue Tang.
  Zheng KY, Choi RC, Guo AJ, Bi CW, Zhu KY, Du CY, Zhang ZX, Lau DT, Dong TT, Tsim KW.J Pharm Biomed Anal. 2012 Nov;70:671-9. doi: 10.1016/j.jpba.2012.05.018. Epub 2012 May 31.

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