Standard Herbal Extract

Gotu Kola Extract Safety Tips

Handling of Gotu Kola Extract should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Characterization of the alkaloids in goldenseal (Hydrastis canadensis) root by high resolution Orbitrap LC-MS(n).
  Le PM, McCooeye M, Windust A.Anal Bioanal Chem. 2012 Nov 24. [Epub ahead of print]
• 2. Analysis of goldenseal, Hydrastis canadensis L., and related alkaloids in urine using HPLC with UV detection.
  Dawes ML, Brettell T.J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jan 1;880(1):114-8. doi: 10.1016/j.jchromb.2011.11.026. Epub 2011 Dec 2.
• 3. Synergy-directed fractionation of botanical medicines: a case study with goldenseal (Hydrastis canadensis).
  Junio HA, Sy-Cordero AA, Ettefagh KA, Burns JT, Micko KT, Graf TN, Richter SJ, Cannon RE, Oberlies NH, Cech NB.J Nat Prod. 2011 Jul 22;74(7):1621-9. doi: 10.1021/np200336g. Epub 2011 Jun 10.
• 4. Investigating the potential for toxicity from long-term use of herbal products, goldenseal, and milk thistle.
  Dunnick JK, Singh B, Nyska A, Peckham J, Kissling GE, Sanders JM.Toxicol Pathol. 2011 Feb;39(2):398-409. doi: 10.1177/0192623310394211. Epub 2011 Feb 7.
• 5. Goldenseal (Hydrastis canadensis L.) extracts synergistically enhance the antibacterial activity of berberine via efflux pump inhibition.
  Ettefagh KA, Burns JT, Junio HA, Kaatz GW, Cech NB.Planta Med. 2011 May;77(8):835-40. doi: 10.1055/s-0030-1250606. Epub 2010 Dec 14.
• 6. Determination of hydrastine and berberine in goldenseal raw materials, extracts, and dietary supplements by high-performance liquid chromatography with UV: collaborative study.
  Brown PN, Roman MC.J AOAC Int. 2008 Jul-Aug;91(4):694-701. Erratum in: J AOAC Int. 2012 Jan-Feb;95(1):286.
• 7. Effects of herbal products and their constituents on human cytochrome P450(2E1) activity.
  Raner GM, Cornelious S, Moulick K, Wang Y, Mortenson A, Cech NB.Food Chem Toxicol. 2007 Dec;45(12):2359-65. Epub 2007 Jun 15.
• 8. An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constituents.
  Etheridge AS, Black SR, Patel PR, So J, Mathews JM.Planta Med. 2007 Jul;73(8):731-41. Epub 2007 Jul 5.
• 9. Effects of root isoquinoline alkaloids from Hydrastis canadensis on Fusarium oxysporum isolated from Hydrastis root tissue.
  Tims Mc, Batista C.J Chem Ecol. 2007 Jul;33(7):1449-55.
• 10. The medicinal plant goldenseal is a natural LDL-lowering agent with multiple bioactive components and new action mechanisms.
  Abidi P, Chen W, Kraemer FB, Li H, Liu J.J Lipid Res. 2006 Oct;47(10):2134-47. Epub 2006 Aug 2.
• 11. A reproductive screening test of goldenseal.
  Yao M, Ritchie HE, Brown-Woodman PD.Birth Defects Res B Dev Reprod Toxicol. 2005 Oct;74(5):399-404.
• 12. Chemical comparison of goldenseal (Hydrastis canadensis L.) root powder from three commercial suppliers.
  Weber HA, Zart MK, Hodges AE, Molloy HM, O’Brien BM, Moody LA, Clark AP, Harris RK, Overstreet JD, Smith CS.J Agric Food Chem. 2003 Dec 3;51(25):7352-8.
• 13. Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components.
  Chatterjee P, Franklin MR.Drug Metab Dispos. 2003 Nov;31(11):1391-7.
• 14. In vitro susceptibility of Helicobacter pylori to isoquinoline alkaloids from Sanguinaria canadensis and Hydrastis canadensis.
  Mahady GB, Pendland SL, Stoia A, Chadwick LR.Phytother Res. 2003 Mar;17(3):217-21.
• 15. Increased production of antigen-specific immunoglobulins G and M following in vivo treatment with the medicinal plants Echinacea angustifolia and Hydrastis canadensis.
  Rehman J, Dillow JM, Carter SM, Chou J, Le B, Maisel AS.Immunol Lett. 1999 Jun 1;68(2-3):391-5.
• 16. Antitubercular natural products: berberine from the roots of commercial Hydrastis canadensis powder. Isolation of inactive 8-oxotetrahydrothalifendine, canadine, beta-hydrastine, and two new quinic acid esters, hycandinic acid esters-1 and -2.
  Gentry EJ, Jampani HB, Keshavarz-Shokri A, Morton MD, Velde DV, Telikepalli H, Mitscher LA, Shawar R, Humble D, Baker W.J Nat Prod. 1998 Oct;61(10):1187-93.

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