Standard Herbal Extract

Grape Bunch Stem Extract Safety Tips

Handling of Grape Bunch Stem Extract should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Evaluation of amygdaloid neuronal dendritic arborization enhancing effect of Centella asiatica (Linn) fresh leaf extract in adult rats.
  Mohandas Rao KG, Rao MS, Rao GS.Chin J Integr Med. 2012 Dec 3. [Epub ahead of print]
• 2. Centella asiatica protects against UVB-induced HaCaT keratinocyte damage through microRNA expression changes.
  An IS, An S, Choe TΒ, Kang SΜ, Lee JH, Park IC, Jin YW, Lee SJ, Bae S.Int J Mol Med. 2012 Dec;30(6):1349-56. doi: 10.3892/ijmm.2012.1157. Epub 2012 Oct 15.
• 3. Titrated extract of Centella asiatica provides a UVB protective effect by altering microRNA expression profiles in human dermal fibroblasts.
  An IS, An S, Kang SM, Choe TB, Lee SN, Jang HH, Bae S.Int J Mol Med. 2012 Nov;30(5):1194-202. doi: 10.3892/ijmm.2012.1117. Epub 2012 Sep 4.
• 4. Inhibition of cPLA2 and sPLA2 activities in primary cultures of rat cortical neurons by Centella asiatica water extract.
  Defillipo PP, Raposo AH, Fedoce AG, Ferreira AS, Polonini HC, Gattaz WF, Raposo NR.Nat Prod Commun. 2012 Jul;7(7):841-3.
• 5. Centella asiatica attenuates the neurobehavioral, neurochemical and histological changes in transient focal middle cerebral artery occlusion rats.
  Tabassum R, Vaibhav K, Shrivastava P, Khan A, Ejaz Ahmed M, Javed H, Islam F, Ahmad S, Saeed Siddiqui M, Safhi MM, Islam F.Neurol Sci. 2012 Aug 4. [Epub ahead of print]
• 6. Anxiolytic effects of standardized extract of Centella asiatica (ECa 233) after chronic immobilization stress in mice.
  Wanasuntronwong A, Tantisira MH, Tantisira B, Watanabe H.J Ethnopharmacol. 2012 Sep 28;143(2):579-85. doi: 10.1016/j.jep.2012.07.010. Epub 2012 Jul 24.
• 7. Wound healing activities of different extracts of Centella asiatica in incision and burn wound models: an experimental animal study.
  Somboonwong J, Kankaisre M, Tantisira B, Tantisira MH.BMC Complement Altern Med. 2012 Jul 20;12:103. doi: 10.1186/1472-6882-12-103.
• 8. Development of photochemoprotective herbs containing cosmetic formulations for improving skin properties.
  Saraf S, Chhabra SK, Kaur CD, Saraf S.J Cosmet Sci. 2012 Mar-Apr;63(2):119-31.
• 9. A new method for preparing pentacyclic triterpene rich Centella asiatica extracts.
  Puttarak P, Panichayupakaranant P.Nat Prod Res. 2012 May 14. [Epub ahead of print]
• 10. Centella asiatica Extract Improves Behavioral Deficits in a Mouse Model of Alzheimer’s Disease: Investigation of a Possible Mechanism of Action.
  Soumyanath A, Zhong YP, Henson E, Wadsworth T, Bishop J, Gold BG, Quinn JF.Int J Alzheimers Dis. 2012;2012:381974. doi: 10.1155/2012/381974. Epub 2012 Feb 15.
• 11. Effect of an herbal mouth rinse in preventing periodontal inflammation in an experimental gingivitis model: a pilot study.
  Samuels N, Grbic JT, Saffer AJ, Wexler ID, Williams RC.Compend Contin Educ Dent. 2012 Mar;33(3):204-6, 208-11.
• 12. A β-cyclodextrin, polyethyleneimine and silk fibroin hydrogel containing Centella asiatica extract and hydrocortisone acetate: releasing properties and in vivo efficacy for healing of pressure sores.
  Lee MS, Seo SR, Kim JC.Clin Exp Dermatol. 2012 Oct;37(7):762-71. doi: 10.1111/j.1365-2230.2011.04331.x. Epub 2012 Mar 22.
• 13. Evaluation of antioxidant activity of two important memory enhancing medicinal plants Baccopa monnieri and Centella asiatica.
  Meena H, Pandey HK, Pandey P, Arya MC, Ahmed Z.Indian J Pharmacol. 2012 Jan;44(1):114-7. doi: 10.4103/0253-7613.91880.
• 14. Aqueous extract of Centella asiatica promotes corneal epithelium wound healing in vitro.
  Ruszymah BH, Chowdhury SR, Manan NA, Fong OS, Adenan MI, Saim AB.J Ethnopharmacol. 2012 Mar 27;140(2):333-8. doi: 10.1016/j.jep.2012.01.023. Epub 2012 Jan 24.
• 15. TECA (Titrated Extract of Centella Asiatica): new microcirculatory, biomolecular, and vascular application in preventive and clinical medicine. A status paper.
  Belcaro G, Maquart FX, Scoccianti M, Dugall M, Hosoi M, Cesarone MR, Luzzi R, Cornelli U, Ledda A, Feragalli B.Panminerva Med. 2011 Sep;53(3 Suppl 1):105-18. Review.
• 16. In vitro inhibitory potential of selected Malaysian plants against key enzymes involved in hyperglycemia and hypertension.
  Loh SP, Hadira O.Malays J Nutr. 2011 Apr;17(1):77-86.
• 17. Centella asiatica extracts modulate hydrogen peroxide-induced senescence in human dermal fibroblasts.
  Kim YJ, Cha HJ, Nam KH, Yoon Y, Lee H, An S.Exp Dermatol. 2011 Dec;20(12):998-1003. doi: 10.1111/j.1600-0625.2011.01388.x.
• 18. Exploring the role of “Brahmi” (Bocopa monnieri and Centella asiatica) in brain function and therapy.
  Shinomol GK, Muralidhara, Bharath MM.Recent Pat Endocr Metab Immune Drug Discov. 2011 Jan;5(1):33-49. Review.
• 19. Enhancement of the skin-protective activities of Centella asiatica L. Urban by a nano-encapsulation process.
  Kwon MC, Choi WY, Seo YC, Kim JS, Yoon CS, Lim HW, Kim HS, Ahn Jh, Lee HY.J Biotechnol. 2012 Jan;157(1):100-6. doi: 10.1016/j.jbiotec.2011.08.025. Epub 2011 Aug 26.
• 20. Common complementary and alternative therapies with potential use in dermatologic surgery: Risks and benefits.
  Reddy KK, Grossman L, Rogers GS.J Am Acad Dermatol. 2011 Sep 2. [Epub ahead of print]

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