Standard Herbal Extract

Grapefruit Seed Extract Safety Tips

Handling of Grapefruit Seed Extract should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Grape seed extract as photochemopreventive agent against UVB-induced skin cancer.
  Perde-Schrepler M, Chereches G, Brie I, Tatomir C, Postescu ID, Soran L, Filip A.J Photochem Photobiol B. 2012 Nov 3. doi:pii: S1011-1344(12)00226-6.  10.1016/j.jphotobiol.2012.10.008. [Epub ahead of print]
• 2. An extract procedure for studying the free and glycosilated aroma compounds in grapes.
  Genovese A, Gambuti A, Lamorte SA, Moio L.Food Chem. 2013 Jan 15;136(2):822-34. doi: 10.1016/j.foodchem.2012.08.061. Epub 2012 Sep 12.
• 3. Modulation of lipid metabolism by polyphenol-rich grape skin extract improves liver steatosis and adiposity in high fat fed mice.
  Park HJ, Jung UJ, Lee MK, Cho SJ, Jung HK, Hong JH, Park YB, Kim SR, Shim S, Jung J, Choi MS.Mol Nutr Food Res. 2012 Oct 29. doi: 10.1002/mnfr.201200447. [Epub ahead of print]
• 4. Protective effect of grape seed and skin extract on garlic-induced erythrocyte oxidative stress.
  Hamlaoui S, Mokni M, Limam N, Zouaoui K, Ben Rayana MC, Carrier A, Limam F, Amri M, Marzouki L, Aouani E.J Physiol Pharmacol. 2012 Aug;63(4):381-8.
• 5. Anti-obesity effect of resveratrol-amplified grape skin extracts on 3T3-L1 adipocytes differentiation.
  Zhang XH, Huang B, Choi SK, Seo JS.Nutr Res Pract. 2012 Aug;6(4):286-93. doi: 10.4162/nrp.2012.6.4.286. Epub 2012 Aug 31.
• 6. Analysis of phenolic composition of Noble muscadine (Vitis rotundifolia) by HPLC-MS and the relationship to its antioxidant capacity.
  You Q, Chen F, Wang X, Sharp JL, You Y.J Food Sci. 2012 Oct;77(10):C1115-23. doi: 10.1111/j.1750-3841.2012.02888.x. Epub 2012 Aug 27.
• 7. Grape skin extract reduces adipogenesis- and lipogenesis-related gene expression in 3T3-L1 adipocytes through the peroxisome proliferator-activated receptor-γ signaling pathway.
  Jeong YS, Hong JH, Cho KH, Jung HK.Nutr Res. 2012 Jul;32(7):514-21. doi: 10.1016/j.nutres.2012.06.001. Epub 2012 Jul 18.
• 8. Clinical and laboratory investigation of oral allergy syndrome to grape.
  Falak R, Sankian M, Tehrani M, Jabbari Azad F, Abolhasani A, Varasteh A.Iran J Allergy Asthma Immunol. 2012 Jun;11(2):147-55. doi: 011.02/ijaai.147155.
• 9. Grape seed proanthocyanidins reactivate silenced tumor suppressor genes in human skin cancer cells by targeting epigenetic regulators.
  Vaid M, Prasad R, Singh T, Jones V, Katiyar SK.Toxicol Appl Pharmacol. 2012 Aug 15;263(1):122-30. doi: 10.1016/j.taap.2012.06.013. Epub 2012 Jun 27.
• 10. Grape seed and skin extract prevents high-fat diet-induced brain lipotoxicity in rat.
  Charradi K, Elkahoui S, Karkouch I, Limam F, Hassine FB, Aouani E.Neurochem Res. 2012 Sep;37(9):2004-13. doi: 10.1007/s11064-012-0821-2. Epub 2012 Jun 9.
• 11. Biomarine extracts significantly protect from ultraviolet A-induced skin photoaging: an ex vivo study.
  Marotta F, Kumari A, Yadav H, Polimeni A, Soresi V, Lorenzetti A, Naito Y, Jain S.Rejuvenation Res. 2012 Apr;15(2):157-60. doi: 10.1089/rej.2011.1267.
• 12. Grape seed and skin extract mitigates garlic-induced oxidative stress in rat liver.
  Hamlaoui-Gasmi S, Mokni M, Limam N, N’guessan P, Carrier A, Limam F, Amri M, Aouani E, Marzouki L.Can J Physiol Pharmacol. 2012 May;90(5):547-56. doi: 10.1139/y2012-025. Epub 2012 Apr 19.
• 13. Clinical, biometric and ultrasound assessment of the effects of daily use of a nutraceutical composed of lycopene, acerola extract, grape seed extract and Biomarine Complex in photoaged human skin.
  Costa A, Lindmark L, Arruda LH, Assumpção EC, Ota FS, Pereira Mde O, Langen SS.An Bras Dermatol. 2012 Jan-Feb;87(1):52-61.
• 14. Grape seed and skin extract protects against acute chemotherapy toxicity induced by doxorubicin in rat heart.
  Mokni M, Hamlaoui-Guesmi S, Amri M, Marzouki L, Limam F, Aouani E.Cardiovasc Toxicol. 2012 Jun;12(2):158-65. doi: 10.1007/s12012-012-9155-1.
• 15. Vitis vinifera L. grape skin extract activates the insulin-signalling cascade and reduces hyperglycaemia in alloxan-induced diabetic mice.
  Soares de Moura R, da Costa GF, Moreira AS, Queiroz EF, Moreira DD, Garcia-Souza EP, Resende AC, Moura AS, Teixeira MT.J Pharm Pharmacol. 2012 Feb;64(2):268-76. doi: 10.1111/j.2042-7158.2011.01395.x. Epub 2011 Nov 18.
• 16. Topical grape seed proanthocyandin extract reduces sunburn cells and mutant p53 positive epidermal cell formation, and prevents depletion of Langerhans cells in an acute sunburn model.
  Yuan XY, Liu W, Hao JC, Gu WJ, Zhao YS.Photomed Laser Surg. 2012 Jan;30(1):20-5. doi: 10.1089/pho.2011.3043. Epub 2011 Nov 21.
• 17. Polyphenols: skin photoprotection and inhibition of photocarcinogenesis.
  Afaq F, Katiyar SK.Mini Rev Med Chem. 2011 Dec;11(14):1200-15. Review.
• 18. Red grape skin and seeds polyphenols: Evidence of their protective effects on endothelial progenitor cells and improvement of their intestinal absorption.
  Felice F, Zambito Y, Di Colo G, D’Onofrio C, Fausto C, Balbarini A, Di Stefano R.Eur J Pharm Biopharm. 2012 Jan;80(1):176-84. doi: 10.1016/j.ejpb.2011.09.002. Epub 2011 Sep 24.
• 19. Aqueous extract from Vitis vinifera tendrils is able to enrich keratinocyte antioxidant defences.
  Fraternale D, De Bellis R, Calcabrini C, Potenza L, Cucchiarini L, Mancini U, Dachà M, Ricci D.Nat Prod Commun. 2011 Sep;6(9):1315-9.
• 20. The effects of grape seeds polyphenols on SKH-1 mice skin irradiated with multiple doses of UV-B.
  Filip A, Daicoviciu D, Clichici S, Bolfa P, Catoi C, Baldea I, Bolojan L, Olteanu D, Muresan A, Postescu ID.J Photochem Photobiol B. 2011 Nov 3;105(2):133-42. doi: 10.1016/j.jphotobiol.2011.08.002. Epub 2011 Aug 26.

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