Standard Herbal Extract

Guarana Seed Extract Safety Tips

Handling of Guarana Seed Extract should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Dermocosmetics for dry skin: a new role for botanical extracts.
  Casetti F, Wölfle U, Gehring W, Schempp CM.Skin Pharmacol Physiol. 2011;24(6):289-93. doi: 10.1159/000329214. Epub 2011 Jun 25. Review.
• 2. Tigloylshikonin, a new minor Shikonin derivative, from the roots and the commercial root extract of lithospermum erythrorhizon.
  Ito Y, Onobori K, Yamazaki T, Kawamura Y.Chem Pharm Bull (Tokyo). 2011;59(1):117-9.
• 3. Lithospermic acid derivatives from Lithospermum erythrorhizon increased expression of serine palmitoyltransferase in human HaCaT cells.
  Thuong PT, Kang KW, Kim JK, Seo DB, Lee SJ, Kim SH, Oh WK.Bioorg Med Chem Lett. 2009 Mar 15;19(6):1815-7. doi: 10.1016/j.bmcl.2009.01.052. Epub 2009 Jan 22.
• 4. Cosmetic formulations containing Lithospermum erythrorhizon root extract show moisturizing effects on human skin.
  Chang MJ, Huang HC, Chang HC, Chang TM.Arch Dermatol Res. 2008 Jul;300(6):317-23. doi: 10.1007/s00403-008-0867-9. Epub 2008 Jun 10.
• 5. Lithospermi radix extract inhibits histamine release and production of inflammatory cytokine in mast cells.
  Kim EK, Kim EY, Moon PD, Um JY, Kim HM, Lee HS, Sohn Y, Park SK, Jung HS, Sohn NW.Biosci Biotechnol Biochem. 2007 Dec;71(12):2886-92. Epub 2007 Dec 7.
• 6. Protection of human keratinocytes from UVB-induced inflammation using root extract of Lithospermum erythrorhizon.
  Ishida T, Sakaguchi I.Biol Pharm Bull. 2007 May;30(5):928-34.
• 7. Non-radioactive and colorimetric quantification of monocyte adhesion to endothelial cells in early atherogenesis.
  Jun HJ, Chung MJ, Kim SY, Lee HJ, Lee SJ.Biotechnol Lett. 2006 Nov;28(22):1805-10. Epub 2006 Sep 26.
• 8. Monoamine oxidase inhibitory naphthoquinones from the roots of Lithospermum erythrorhizon.
  Choi WH, Hong SS, Lee SA, Han XH, Lee KS, Lee MK, Hwang BY, Ro JS.Arch Pharm Res. 2005 Apr;28(4):400-4.
• 9. Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo.
  Staniforth V, Wang SY, Shyur LF, Yang NS.J Biol Chem. 2004 Feb 13;279(7):5877-85. Epub 2003 Nov 25.
• 10. An extract of the root of Lithospermun erythrorhison accelerates wound healing in diabetic mice.
  Fujita N, Sakaguchi I, Kobayashi H, Ikeda N, Kato Y, Minamino M, Ishii M.Biol Pharm Bull. 2003 Mar;26(3):329-35.
• 11. Shikonin production by extractive cultivation in transformed-suspension and hairy root cultures of Lithospermum erythrorhizon.
  Sim SJ, Kim DJ, Chang HN.Ann N Y Acad Sci. 1994 Nov 30;745:442-54.
• 12. [Screening test of crude drug extract on anti-HIV activity].
  Yamasaki K, Otake T, Mori H, Morimoto M, Ueba N, Kurokawa Y, Shiota K, Yuge T.Yakugaku Zasshi. 1993 Nov;113(11):818-24. Japanese.

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