Standard Herbal Extract

Hawthorn Leaf Extract Safety Tips

Handling of Hawthorn Leaf Extract should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Polyphenolic Profile and Biological Activity of Chinese Hawthorn (Crataegus pinnatifida BUNGE) Fruits.
  Jurikova T, Sochor J, Rop O, Mlcek J, Balla S, Szekeres L, Adam V, Kizek R.Molecules. 2012 Dec 6;17(12):14490-509. doi: 10.3390/molecules171214490.
• 2. An extract of Crataegus pinnatifida fruit attenuates airway inflammation by modulation of matrix metalloproteinase-9 in ovalbumin induced asthma.
  Shin IS, Lee MY, Lim HS, Ha H, Seo CS, Kim JC, Shin HK.PLoS One. 2012;7(9):e45734. doi: 10.1371/journal.pone.0045734. Epub 2012 Sep 21.
• 3. The evaluation of chinese therapeutic food for the treatment of moderate dyslipidemia.
  Sun S, Xu H, Ngeh L.Evid Based Complement Alternat Med. 2012;2012:508683. doi: 10.1155/2012/508683. Epub 2012 Mar 14.
• 4. Antioxidant activity of polyphenol and ultrasonic extracts from fruits of Crataegus pentagyna subsp. elburensis.
  Rabiei Kh, Bekhradnia S, Nabavi SM, Nabavi SF, Ebrahimzadeh MA.Nat Prod Res. 2012 Dec;26(24):2353-7. doi: 10.1080/14786419.2012.658799. Epub 2012 Mar 19.
• 5. Anti-inflammatory and anti-apoptotic effects of Crataegus oxyacantha on isoproterenol-induced myocardial damage.
  Vijayan NA, Thiruchenduran M, Devaraj SN.Mol Cell Biochem. 2012 Aug;367(1-2):1-8. doi: 10.1007/s11010-012-1251-9. Epub 2012 Feb 15.
• 6. Crataegus monogyna aqueous extract ameliorates cyclophosphamide-induced toxicity in rat testis: stereological evidences.
  Jalali AS, Hasanzadeh S, Malekinejad H.Acta Med Iran. 2012;50(1):1-8.
• 7. Decrease of blood lipids induced by Shan-Zha (fruit of Crataegus pinnatifida) is mainly related to an increase of PPARα in liver of mice fed high-fat diet.
  Niu C, Chen C, Chen L, Cheng K, Yeh C, Cheng J.Horm Metab Res. 2011 Aug;43(9):625-30. doi: 10.1055/s-0031-1283147. Epub 2011 Aug 5.
• 8. Assessment of phenolic acid content and in vitro antiradical characteristics of hawthorn.
  Öztürk N, Tunçel M.J Med Food. 2011 Jun;14(6):664-9. doi: 10.1089/jmf.2010.0063. Epub 2011 May 9.
• 9. Protective effect of hawthorn extract against genotoxicity induced by methyl methanesulfonate in human lymphocytes.
  Hosseinimehr SJ, Azadbakht M, Tanha M, Mahmodzadeh A, Mohammadifar S.Toxicol Ind Health. 2011 May;27(4):363-9. doi: 10.1177/0748233710387010. Epub 2010 Oct 14.
• 10. Protein oxidation in emulsified cooked burger patties with added fruit extracts: Influence on colour and texture deterioration during chill storage.
  Ganhão R, Morcuende D, Estévez M.Meat Sci. 2010 Jul;85(3):402-9. doi: 10.1016/j.meatsci.2010.02.008. Epub 2010 Feb 13.
• 11. Tryptophan depletion and formation of alpha-aminoadipic and gamma-glutamic semialdehydes in porcine burger patties with added phenolic-rich fruit extracts.
  Ganhão R, Morcuende D, Estévez M.J Agric Food Chem. 2010 Mar 24;58(6):3541-8. doi: 10.1021/jf903356m.
• 12. Synergetic effect and structure-activity relationship of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors from Crataegus pinnatifida Bge.
  Ye XL, Huang WW, Chen Z, Li XG, Li P, Lan P, Wang L, Gao Y, Zhao ZQ, Chen X.J Agric Food Chem. 2010 Mar 10;58(5):3132-8. doi: 10.1021/jf903337f.
• 13. A study of the comparative effects of hawthorn fruit compound and simvastatin on lowering blood lipid levels.
  Xu H, Xu HE, Ryan D.Am J Chin Med. 2009;37(5):903-8.
• 14. Antioxidant activity of Crataegus pentaegyna subsp. elburensis fruits extracts used in traditional medicine in Iran.
  Ebrahimzadeh MA, Bahramian F.Pak J Biol Sci. 2009 Mar 1;12(5):413-9.
• 15. D-camphor-crataegus berry extract combination increases blood pressure and cognitive functioning in the elderly – a randomized, placebo controlled double blind study.
  Werner NS, Duschek S, Schandry R.Phytomedicine. 2009 Dec;16(12):1077-82. doi: 10.1016/j.phymed.2009.05.006. Epub 2009 Jun 26.
• 16. The effect of crataegus fruit extract and some of its flavonoids on mitochondrial oxidative phosphorylation in the heart.
  Bernatoniene J, Trumbeckaite S, Majiene D, Baniene R, Baliutyte G, Savickas A, Toleikis A.Phytother Res. 2009 Dec;23(12):1701-7. doi: 10.1002/ptr.2815.
• 17. Triterpenic Acids Present in Hawthorn Lower Plasma Cholesterol by Inhibiting Intestinal ACAT Activity in Hamsters.
  Lin Y, Vermeer MA, Trautwein EA.Evid Based Complement Alternat Med. 2011;2011:801272. doi: 10.1093/ecam/nep007. Epub 2010 Oct 19.
• 18. Liquid chromatography tandem mass spectrometry identification of proanthocyanidins in rat plasma after oral administration of grape seed extract.
  Prasain JK, Peng N, Dai Y, Moore R, Arabshahi A, Wilson L, Barnes S, Michael Wyss J, Kim H, Watts RL.Phytomedicine. 2009 Mar;16(2-3):233-43. doi: 10.1016/j.phymed.2008.08.006. Epub 2008 Dec 17.
• 19. Free radical-scavenging activities of Crataegus monogyna extracts.
  Bernatoniene J, Masteikova R, Majiene D, Savickas A, Kevelaitis E, Bernatoniene R, Dvorácková K, Civinskiene G, Lekas R, Vitkevicius K, Peciura R.Medicina (Kaunas). 2008;44(9):706-12.
• 20. The effect of Camphor-Crataegus berry extract combination on blood pressure and mental functions in chronic hypotension – A randomized placebo controlled double blind design.
  Schandry R, Duschek S.Phytomedicine. 2008 Nov;15(11):914-22. doi: 10.1016/j.phymed.2008.09.002.

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