Botanical Ingredient

Helicid Safety Tips

Handling of Helicid should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Metabolite discovery of helicidum in rat urine with XCMS based on the data of ultra performance liquid chromatography coupled to time-of-flight mass spectrometry.
  Liu Q, Shi Y, Guo T, Wang Y, Cong W, Zhu J.J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Oct 15;907:146-53. doi: 10.1016/j.jchromb.2012.09.029. Epub 2012 Sep 20.
• 2. Intensity of parasitic mite infection decreases with hibernation duration of the host snail.
  Haeussler EM, Pizá J, Schmera D, Baur B.Parasitology. 2012 Jul;139(8):1038-44. doi: 10.1017/S0031182012000327. Epub 2012 Mar 23.
• 3. LC-MS/MS determination of helicid in human plasma and its application in pharmacokinetic studies.
  Xie H, Jia Y, Tan Z, Zhang W, Chen R, Sun H, Shen J, Zhou H.J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Nov 15;879(30):3607-11. doi: 10.1016/j.jchromb.2011.10.001. Epub 2011 Oct 7.
• 4. Reappraisal of the “Molecular phylogeny of Western Palaearctic Helicidae s.l. (Gastropoda: Stylommatophora)”: when poor science meets GenBank.
  Groenenberg DS, Neubert E, Gittenberger E.Mol Phylogenet Evol. 2011 Dec;61(3):914-23. doi: 10.1016/j.ympev.2011.08.024. Epub 2011 Sep 10.
• 5. Physiological relevance and contribution to metal balance of specific and non-specific Metallothionein isoforms in the garden snail, Cantareus aspersus.
  Höckner M, Stefanon K, de Vaufleury A, Monteiro F, Pérez-Rafael S, Palacios O, Capdevila M, Atrian S, Dallinger R.Biometals. 2011 Dec;24(6):1079-92. doi: 10.1007/s10534-011-9466-x. Epub 2011 May 31.
• 6. Brachylaima aspersae n. sp. (Digenea: Brachylaimidae) infecting farmed snails in NW Spain: morphology, life cycle, pathology, and implications for heliciculture.
  Segade P, Crespo C, García N, García-Estévez JM, Arias C, Iglesias R.Vet Parasitol. 2011 Feb 10;175(3-4):273-86. doi: 10.1016/j.vetpar.2010.10.026. Epub 2010 Oct 21.
• 7. Within- and among-family variation in parasite load and parasite-induced mortality in the land snail Arianta arbustorum, a host of parasitic mites.
  Schüpbach HU, Baur B.J Parasitol. 2010 Aug;96(4):830-2. doi: 10.1645/GE-2315.1.
• 8. Multicomponent amorphous nanofibers electrospun from hot aqueous solutions of a poorly soluble drug.
  Yu DG, Gao LD, White K, Branford-White C, Lu WY, Zhu LM.Pharm Res. 2010 Nov;27(11):2466-77. doi: 10.1007/s11095-010-0239-y. Epub 2010 Aug 19.
• 9. Magnesium and the regulation of lead in three populations of the garden snail Cantareus aspersus.
  Beeby A, Richmond L.Environ Pollut. 2010 Jun;158(6):2288-93. doi: 10.1016/j.envpol.2010.02.002. Epub 2010 Mar 4.
• 10. Quantitative determination of helicid in rat biosamples by liquid chromatography electrospray ionization mass spectrometry.
  Jia Y, Xie H, Wang G, Sun J, Wang W, Qing H, Wang X, Yang H, Xu M, Gu Y, Yao C, Shen J.J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Mar 15;878(9-10):791-7. doi: 10.1016/j.jchromb.2010.01.038. Epub 2010 Jan 29.
• 11. [The improvement of poorly water-soluble drug solubility through electrospun drug-loaded nanofibers].
  Yu DG, Zhang XF, Shen XX, Branford-White C, Zhu LM.Yao Xue Xue Bao. 2009 Oct;44(10):1179-82. Chinese.
• 12. Coping with cadmium exposure in various ways: the two helicid snails Helix pomatia and Cantareus aspersus share the metal transcription factor-2, but differ in promoter organization and transcription of their Cd-metallothionein genes.
  Höckner M, Stefanon K, Schuler D, Fantur R, de Vaufleury A, Dallinger R.J Exp Zool A Ecol Genet Physiol. 2009 Dec 1;311(10):776-87. doi: 10.1002/jez.564.
• 13. [Investigation on pharmacokinetics of helicid in rats].
  Chen Z, Jiang XH, Ren J, Liu TM, Ma G, Wang L.Zhongguo Zhong Yao Za Zhi. 2008 Nov;33(22):2662-6. Chinese.
• 14. (E)-4-(β-d-Allopyran-os-yloxy)cinnamyl 4-bromo-phenyl ketone ethanol solvate.
  Yin XJ, Bai X, Zheng L, Li Y, Yin SF.Acta Crystallogr Sect E Struct Rep Online. 2009 Jul 31;65(Pt 8):o2044. doi: 10.1107/S1600536809029687.
• 15. 1-[4-(2,3,4,6-Tetra-O-acetyl-β-d-allo-pyranos-yloxy)benzyl-idene]thio-semi-carbazide.
  Fu L, Yin XJ, Zheng L, Li Y, Yin SF.Acta Crystallogr Sect E Struct Rep Online. 2009 Mar 6;65(Pt 4):o679. doi: 10.1107/S1600536809007260.
• 16. E-[4-(β-d-Allopyranos-yloxy)phen-yl]-1-(4-chloro-phen-yl)prop-2-enone ethanol solvate.
  Yang CL, Luo HL, Yin XJ, Li Y, Yin SF.Acta Crystallogr Sect E Struct Rep Online. 2009 Feb 28;65(Pt 3):o634. doi: 10.1107/S1600536809006424.
• 17. Experimental evidence for a new transmission route in a parasitic mite and its mucus-dependent orientation towards the host snail.
  Schüpbach HU, Baur B.Parasitology. 2008 Dec;135(14):1679-84. doi: 10.1017/S0031182008005039. Epub 2008 Nov 12.
• 18. Synthesis and biological evaluation of helicid analogues as mushroom tyrosinase inhibitors.
  Yi W, Cao R, Wen H, Yan Q, Zhou B, Wan Y, Ma L, Song H.Bioorg Med Chem Lett. 2008 Dec 15;18(24):6490-3. doi: 10.1016/j.bmcl.2008.10.056. Epub 2008 Oct 17.
• 19. Application of elemental microanalysis to elucidate the role of spherites in the digestive gland of the helicid snail Chilostoma lefeburiana.
  Delakorda SL, Letofsky-Papst I, Novak T, Giovannelli M, Hofer F, Pabst MA.J Microsc. 2008 Jul;231(Pt 1):38-46. doi: 10.1111/j.1365-2818.2008.02015.x.
• 20. Analysis of currently used pesticides in fine airborne particulate matter (PM 2.5) by pressurized liquid extraction and liquid chromatography-tandem mass spectrometry.
  Coscollà C, Yusà V, Martí P, Pastor A.J Chromatogr A. 2008 Jul 25;1200(2):100-7. doi: 10.1016/j.chroma.2008.05.075. Epub 2008 Jun 21.