Botanical Ingredient

Hesperetin Safety Tips

Handling of Hesperetin should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. A comparison study on the binding of hesperetin and luteolin to bovine serum albumin by spectroscopy.
  Tang L, Jia W.Spectrochim Acta A Mol Biomol Spectrosc. 2012 Nov 7;103C:114-119. doi: 10.1016/j.saa.2012.10.068. [Epub ahead of print]
• 2. The citrus flavonone hesperetin prevents letrozole-induced bone loss in a mouse model of breast cancer.
  Li F, Chow S, Cheung WH, Chan FL, Chen S, Leung LK.J Nutr Biochem. 2012 Dec 10. doi:pii: S0955-2863(12)00227-6.  10.1016/j.jnutbio.2012.08.010. [Epub ahead of print]
• 3. Assessment of phytochemical content in human milk during different stages of lactation.
  Song BJ, Jouni ZE, Ferruzzi MG.Nutrition. 2013 Jan;29(1):195-202. doi: 10.1016/j.nut.2012.07.015.
• 4. The inhibitory effect of polyphenols on human gut microbiota.
  Duda-Chodak A.J Physiol Pharmacol. 2012 Oct;63(5):497-503.
• 5. Antioxidant and hepatoprotective effects of Schisandra chinensis pollen extract on CCl(4)-induced acute liver damage in mice.
  Cheng N, Ren N, Gao H, Lei X, Zheng J, Cao W.Food Chem Toxicol. 2012 Nov 28. doi:pii: S0278-6915(12)00829-0.  10.1016/j.fct.2012.11.022. [Epub ahead of print]
• 6. Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3.
  Straub I, Mohr F, Stab J, Konrad M, Philipp S, Oberwinkler J, Schaefer M.Br J Pharmacol. 2012 Nov 28. doi: 10.1111/bph.12076. [Epub ahead of print]
• 7. Hesperetin: An inhibitor of the transforming growth factor-β (TGF-β) signaling pathway.
  Yang Y, Wolfram J, Shen H, Fang X, Ferrari M.Eur J Med Chem. 2012 Dec;58:390-5. doi: 10.1016/j.ejmech.2012.10.028. Epub 2012 Oct 25.
• 8. Pharmacokinetics of Hesperetin and Naringenin in the Zhi Zhu Wan, a Traditional Chinese Medicinal Formulae, and its Pharmacodynamics Study.
  Sun H, Dong T, Zhang A, Yang J, Yan G, Sakurai T, Wu X, Han Y, Wang X.Phytother Res. 2012 Nov 12. doi: 10.1002/ptr.4867. [Epub ahead of print]
• 9. Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions.
  Shirasaka Y, Shichiri M, Mori T, Nakanishi T, Tamai I.J Pharm Sci. 2013 Jan;102(1):280-8. doi: 10.1002/jps.23357. Epub 2012 Nov 6.
• 10. Identification of flavonoids with trypsin inhibitory activity extracted from orange peel and green tea leaves.
  Shahwar D, Raza MA, Atta-Ur-Rahman.J Sci Food Agric. 2012 Sep 11. doi: 10.1002/jsfa.5910. [Epub ahead of print]
• 11. Hesperidinase encapsulation towards hesperitin production targeting improved bioavailability.
  Furtado AF, Nunes MA, Ribeiro MH.J Mol Recognit. 2012 Nov;25(11):595-603. doi: 10.1002/jmr.2224.
• 12. Composition of native Australian herbs polyphenolic-rich fractions and in vitro inhibitory activities against key enzymes relevant to metabolic syndrome.
  Sakulnarmrat K, Konczak I.Food Chem. 2012 Sep 15;134(2):1011-9. doi: 10.1016/j.foodchem.2012.02.217. Epub 2012 Mar 8.
• 13. Empirical, thermodynamic, and quantum-chemical investigations of inclusion complexation between flavanones and (2-hydroxypropyl)-cyclodextrins.
  Liu B, Li W, Nguyen TA, Zhao J.Food Chem. 2012 Sep 15;134(2):926-32. doi: 10.1016/j.foodchem.2012.02.207. Epub 2012 Mar 8.
• 14. Hesperetin impairs glucose uptake and inhibits proliferation of breast cancer cells.
  Yang Y, Wolfram J, Boom K, Fang X, Shen H, Ferrari M.Cell Biochem Funct. 2012 Oct 8. doi: 10.1002/cbf.2905. [Epub ahead of print]
• 15. Iron reduction potentiates hydroxyl radical formation only in flavonols.
  Macáková K, Mladenka P, Filipský T, ?íha M, Jahodá? L, Trejtnar F, Bovicelli P, Proietti Silvestri I, Hrdina R, Saso L.Food Chem. 2012 Dec 15;135(4):2584-92. doi: 10.1016/j.foodchem.2012.06.107. Epub 2012 Jul 14.
• 16. Enzymatic bioconversion of citrus hesperidin by Aspergillus sojae naringinase: enhanced solubility of hesperetin-7-O-glucoside with in vitro inhibition of human intestinal maltase, HMG-CoA reductase, and growth of Helicobacter pylori.
  Lee YS, Huh JY, Nam SH, Moon SK, Lee SB.Food Chem. 2012 Dec 15;135(4):2253-9. doi: 10.1016/j.foodchem.2012.07.007. Epub 2012 Jul 14.
• 17. Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress.
  Chen ZT, Chu HL, Chyau CC, Chu CC, Duh PD.Food Chem. 2012 Dec 15;135(4):2119-27. doi: 10.1016/j.foodchem.2012.07.041. Epub 2012 Jul 15.
• 18. 7,3′-dimethoxy hesperetin inhibits inflammation by inducing synovial apoptosis in rats with adjuvant-induced arthritis.
  Li R, Cai L, Xie XF, Peng L, Wu TN, Li J.Immunopharmacol Immunotoxicol. 2013 Feb;35(1):139-46. doi: 10.3109/08923973.2012.723010. Epub 2012 Sep 17.
• 19. Hesperetin ameliorates hyperglycemia induced retinal vasculopathy via anti-angiogenic effects in experimental diabetic rats.
  Kumar B, Gupta SK, Srinivasan BP, Nag TC, Srivastava S, Saxena R.Vascul Pharmacol. 2012 Nov-Dec;57(5-6):201-7. doi: 10.1016/j.vph.2012.02.007. Epub 2012 Feb 21.
• 20. Evaluation of matrix effect in determination of some bioflavonoids in food samples by LC-MS/MS method.
  ?iri? A, Prosen H, Jeliki?-Stankov M, ?ur?evi? P.Talanta. 2012 Sep 15;99:780-90. doi: 10.1016/j.talanta.2012.07.025. Epub 2012 Jul 20.

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