Botanical Ingredient

Hesperidin Methyl Chalcone Safety Tips

Handling of Hesperidin Methyl Chalcone should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Quality of life improvement in Latin American patients suffering from chronic venous disorder using a combination of Ruscus aculeatus and hesperidin methyl-chalcone and ascorbic acid (quality study).
  Guex JJ, Avril L, Enrici E, Enriquez E, Lis C, Taïeb C.Int Angiol. 2010 Dec;29(6):525-32.
• 2. Assessment of quality of life in Mexican patients suffering from chronic venous disorder – impact of oral Ruscus aculeatus-hesperidin-methyl-chalcone-ascorbic acid treatment – ‘QUALITY Study’.
  Guex JJ, Enriquez Vega DM, Avril L, Boussetta S, Taïeb C.Phlebology. 2009 Aug;24(4):157-65. doi: 10.1258/phleb.2009.008066.
• 3. Meta-analysis of clinical trials of Cyclo 3 Fort in the treatment of chronic venous insufficiency.
  Boyle P, Diehm C, Robertson C.Int Angiol. 2003 Sep;22(3):250-62.
• 4. An open-label, randomized multicenter study comparing the efficacy and safety of Cyclo 3 Fort versus hydroxyethyl rutoside in chronic venous lymphatic insufficiency.
  Beltramino R, Penenory A, Buceta AM.Angiology. 2000 Jul;51(7):535-44.
• 5. An open-label, randomised multicentre study comparing the efficacy and safety of CYCLO 3 FORT versus hydroxyethyl rutoside in chronic venous lymphatic insufficiency.
  Beltramino R, Penenory A, Buceta AM.Int Angiol. 1999 Dec;18(4):337-42.
• 6. Treatment of secondary lymphedema of the upper limb with CYCLO 3 FORT.
  Cluzan RV, Alliot F, Ghabboun S, Pascot M.Lymphology. 1996 Mar;29(1):29-35.
• 7. [Improving venous tone and capillary sealing. Effect of a combination of Ruscus extract and hesperidine methyl chalcone in healthy probands in heat stress].
  Rudofsky G.Fortschr Med. 1989 Jun 30;107(19):52, 55-8. German.
• 8. A thin-layer chromatographic-fluorometric method for quantitative analysis of hesperidin methyl chalcone in parmaceuticals.
  Silvestri S.Pharm Acta Helv. 1970 Jun;45(6):390-1. No abstract available.
• 9. Effect of hesperidin-methyl-chalcone on capillary resistance in the internal organs of the guinea pig and the rat.
  Gábor M, Antal A, Dirner Z.Acta Physiol Acad Sci Hung. 1968;34(3):221-6. No abstract available.
• 10. The effect of hesperidin methyl chalcone on the nervous control of the nictitating membrane.
  DONTAS AS, CHENOWETH MB.Arch Int Pharmacodyn Ther. 1952 Sep 1;91(1-2):202-10. English, Undetermined Language.  No abstract available.
• 11. Effect of hesperidin methyl chalcone, vitamin P, on diabetic retinopathy.
  PECK FB, MANN M.Am J Med Sci. 1949 Mar;217(3):277-82. No abstract available.
• 12. Administration of massive doses of vitamin P hesperidin methyl chalcone.
  KIRTLEY WR, PECK FB.Am J Med Sci. 1948 Jul;216(1):64-70. No abstract available.
• 13. THE INFLUENCE OF METHYL CHALCONE OF HESPERIDIN ON THE TOXICITY OF MAPHARSEN IN RABBITS.
  Goldstein DH, Stolman A, Goldfarb AE.Science. 1943 Sep 10;98(2541):245-6. No abstract available.

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