Botanical Ingredient

Huperzine A Safety Tips

Handling of Huperzine A should only be performed by personnel trained and familiar with the handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Huperzine A for mild cognitive impairment.
  Yue J, Dong BR, Lin X, Yang M, Wu HM, Wu T.Cochrane Database Syst Rev. 2012 Dec 12;12:CD008827. doi: 10.1002/14651858.CD008827.pub2.
• 2. Energy Landscapes of Human Acetylcholinesterase and Its Huperzine A-Inhibited Counterpart.
  Trapp M, Trovaslet M, Nachon F, Koza MM, van Eijck L, Hill F, Weik M, Masson P, Tehei M, Peters J.J Phys Chem B. 2012 Dec 13. [Epub ahead of print]
• 3. [Effect of Panax notoginseng saponins on expression of alpha-secretase mRNA in brains of senescence-accelerated SAMP8 mice].
  Huang J, Li F, Wu D, Lu L, Gao Y, Zhong Z.Zhongguo Zhong Yao Za Zhi. 2012 Jul;37(14):2127-9. Chinese.
• 4. A combination of [+] and [-]-Huperzine A improves protection against soman toxicity compared to [+]-Huperzine A in guinea pigs.
  Wang Y, Wei Y, Oguntayo S, Doctor BP, Nambiar MP.Chem Biol Interact. 2012 Nov 2. doi:pii: S0009-2797(12)00222-0.  10.1016/j.cbi.2012.10.016. [Epub ahead of print]
• 5. Bis(12)-hupyridone, a novel acetylcholinesterase inhibitor, protects against glutamate-induced neuronal excitotoxicity via activating α7 nicotinic acetylcholine receptor/phosphoinositide 3-kinase/Akt cascade.
  Cui W, Hu S, Chan HH, Luo J, Li W, Mak S, Choi TC, Rong J, Carlier PR, Han Y.Chem Biol Interact. 2012 Oct 16. doi:pii: S0009-2797(12)00200-1.  10.1016/j.cbi.2012.10.003. [Epub ahead of print]
• 6. Huperzia quadrifariata and Huperzia reflexa alkaloids inhibit acetylcholinesterase activity in vivo in mice brain.
  Konrath EL, Neves BM, Passos Cdos S, Lunardi PS, Ortega MG, Cabrera JL, Gonçalves CA, Henriques AT.Phytomedicine. 2012 Nov 15;19(14):1321-4. doi: 10.1016/j.phymed.2012.08.009. Epub 2012 Sep 28.
• 7. New insights into huperzine A for the treatment of Alzheimer’s disease.
  Zhang HY.Acta Pharmacol Sin. 2012 Sep;33(9):1170-5. doi: 10.1038/aps.2012.128. Epub 2012 Sep 3.
• 8. On-line immobilized acetylcholinesterase microreactor for screening of inhibitors from natural extracts by capillary electrophoresis.
  Min W, Wang W, Chen J, Wang A, Hu Z.Anal Bioanal Chem. 2012 Nov;404(8):2397-405. doi: 10.1007/s00216-012-6333-8. Epub 2012 Aug 30.
• 9. Molecular cloning and characterization of copper amine oxidase from Huperzia serrata.
  Sun J, Morita H, Chen G, Noguchi H, Abe I.Bioorg Med Chem Lett. 2012 Sep 15;22(18):5784-90. doi: 10.1016/j.bmcl.2012.07.102. Epub 2012 Aug 7.
• 10. An efficient total synthesis of (-)-huperzine A.
  Ding R, Sun BF, Lin GQ.Org Lett. 2012 Sep 7;14(17):4446-9. doi: 10.1021/ol301951r. Epub 2012 Aug 17.
• 11. Simultaneously preparative purification of Huperzine A and Huperzine B from Huperzia serrata by macroporous resin and preparative high performance liquid chromatography.
  Zhang H, Liang H, Kuang P, Yuan Q, Wang Y.J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Sep 1;904:65-72. doi: 10.1016/j.jchromb.2012.07.019. Epub 2012 Jul 24.
• 12. Lycopodiaceae from Panama: A new source of acetylcholinesterase inhibitors.
  Calderón AI, Simithy-Williams J, Sanchez R, Espinosa A, Valdespino I, Gupta MP.Nat Prod Res. 2012 Jul 2. [Epub ahead of print]
• 13. Huperzine A ameliorates cognitive deficits and oxidative stress in the hippocampus of rats exposed to acute hypobaric hypoxia.
  Shi Q, Fu J, Ge D, He Y, Ran J, Liu Z, Wei J, Diao T, Lu Y.Neurochem Res. 2012 Sep;37(9):2042-52. doi: 10.1007/s11064-012-0826-x. Epub 2012 Jun 19.
• 14. Huprine X and Huperzine A Improve Cognition and Regulate Some Neurochemical Processes Related with Alzheimer’s Disease in Triple Transgenic Mice (3xTg-AD).
  Ratia M, Giménez-Llort L, Camps P, Muñoz-Torrero D, Pérez B, Clos MV, Badia A.Neurodegener Dis. 2012 May 24. [Epub ahead of print]
• 15. Examining the interactome of huperzine A by magnetic biopanning.
  Guo W, Liu S, Peng J, Wei X, Sun Y, Qiu Y, Gao G, Wang P, Xu Y.PLoS One. 2012;7(5):e37098. doi: 10.1371/journal.pone.0037098. Epub 2012 May 16.
• 16. Huperzine A-phospholipid complex-loaded biodegradable thermosensitive polymer gel for controlled drug release.
  Cai X, Luan Y, Jiang Y, Song A, Shao W, Li Z, Zhao Z.Int J Pharm. 2012 Aug 20;433(1-2):102-11. doi: 10.1016/j.ijpharm.2012.05.009. Epub 2012 May 11.
• 17. Steroidal alkaloids from Holarrhena antidysenterica as acetylcholinesterase inhibitors and the investigation for structure-activity relationships.
  Yang ZD, Duan DZ, Xue WW, Yao XJ, Li S.Life Sci. 2012 Jun 14;90(23-24):929-33. doi: 10.1016/j.lfs.2012.04.017. Epub 2012 Apr 30.
• 18. Decreased accumulation of subcellular amyloid-β with improved mitochondrial function mediates the neuroprotective effect of huperzine A.
  Yang L, Ye CY, Huang XT, Tang XC, Zhang HY.J Alzheimers Dis. 2012;31(1):131-42. doi: 10.3233/JAD-2012-120274.
• 19. Huperzine A ameliorates experimental autoimmune encephalomyelitis via the suppression of T cell-mediated neuronal inflammation in mice.
  Wang J, Chen F, Zheng P, Deng W, Yuan J, Peng B, Wang R, Liu W, Zhao H, Wang Y, Wu G.Exp Neurol. 2012 Jul;236(1):79-87. doi: 10.1016/j.expneurol.2012.03.024. Epub 2012 Apr 15.
• 20. Development and validation of a simple assay for the determination of cholinesterase activity in whole blood of laboratory animals.
  Naik RS, Liu W, Saxena A.J Appl Toxicol. 2012 Mar 12. doi: 10.1002/jat.2730. [Epub ahead of print]

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