Standard Herbal Extract

Lotus Leaf Extract Safety Tips

Handling of Lotus Leaf Extract should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Protective changes of inflammation-related gene expression by the leaves of Eriobotrya japonica in the LPS-stimulated human gingival fibroblast: microarray analysis.
  Choi YG, Seok YH, Yeo S, Jeong MY, Lim S.J Ethnopharmacol. 2011 Jun 1;135(3):636-45. doi: 10.1016/j.jep.2011.03.066. Epub 2011 Apr 5.
• 2. Eriobotrya japonica hydrophilic extract modulates cytokines in normal tissues, in the tumor of Meth-A-fibrosarcoma bearing mice, and enhances their survival time.
  Alshaker HA, Qinna NA, Qadan F, Bustami M, Matalka KZ.BMC Complement Altern Med. 2011 Feb 4;11:9. doi: 10.1186/1472-6882-11-9.
• 3. [An optimized method for extracting corosolic acid from loquat leaves].
  He JR, Liu Q, Bai ZL, Huang RQ, Wang ZL.Nan Fang Yi Ke Da Xue Xue Bao. 2010 Nov;30(11):2533-5. Chinese.
• 4. In silico discovery of acylated flavonol monorhamnosides from Eriobotrya japonica as natural, small-molecular weight inhibitors of XIAP BIR3.
  Pfisterer PH, Shen C, Nikolovska-Coleska Z, Schyschka L, Schuster D, Rudy A, Wolber G, Vollmar AM, Rollinger JM, Stuppner H.Bioorg Med Chem. 2011 Jan 15;19(2):1002-9. doi: 10.1016/j.bmc.2010.10.046. Epub 2010 Oct 25.
• 5. Eriobotryae folium extract suppresses LPS-induced iNOS and COX-2 expression by inhibition of NF-kappaB and MAPK activation in murine macrophages.
  Uto T, Suangkaew N, Morinaga O, Kariyazono H, Oiso S, Shoyama Y.Am J Chin Med. 2010;38(5):985-94.
• 6. Hypotriacylglycerolemic and antiobesity properties of a new fermented tea product obtained by tea-rolling processing of third-crop green tea (Camellia sinensis) leaves and loquat (Eriobotrya japonica) leaves.
  Tanaka K, Tamaru S, Nishizono S, Miyata Y, Tamaya K, Matsui T, Tanaka T, Echizen Y, Ikeda I.Biosci Biotechnol Biochem. 2010;74(8):1606-12. Epub 2010 Aug 7.
• 7. Identification of alpha-glucosidase inhibitors from a new fermented tea obtained by tea-rolling processing of loquat (Eriobotrya japonica) and green tea leaves.
  Toshima A, Matsui T, Noguchi M, Qiu J, Tamaya K, Miyata Y, Tanaka T, Tanaka K.J Sci Food Agric. 2010 Jul;90(9):1545-50. doi: 10.1002/jsfa.3983.
• 8. Suppression of blood glucose level by a new fermented tea obtained by tea-rolling processing of loquat (Eriobotrya japonica) and green tea leaves in disaccharide-loaded Sprague-Dawley rats.
  Tamaya K, Matsui T, Toshima A, Noguchi M, Ju Q, Miyata Y, Tanaka T, Tanaka K.J Sci Food Agric. 2010 Apr 15;90(5):779-83. doi: 10.1002/jsfa.3883.
• 9. Anti-inflammatory effect of leaves of Eriobotrya japonica correlating with attenuation of p38 MAPK, ERK, and NF-kappaB activation in mast cells.
  Kim SH, Shin TY.Toxicol In Vitro. 2009 Oct;23(7):1215-9. doi: 10.1016/j.tiv.2009.07.036. Epub 2009 Aug 7.
• 10. Cinchonain Ib isolated from Eriobotrya japonica induces insulin secretion in vitro and in vivo.
  Qa’dan F, Verspohl EJ, Nahrstedt A, Petereit F, Matalka KZ.J Ethnopharmacol. 2009 Jul 15;124(2):224-7. doi: 10.1016/j.jep.2009.04.023. Epub 2009 May 3.
• 11. Euscaphic acid, a new hypoglycemic natural product from Folium Eriobotryae.
  Chen J, Li WL, Wu JL, Ren BR, Zhang HQ.Pharmazie. 2008 Oct;63(10):765-7.
• 12. The differential effect of Eriobotrya japonica hydrophilic leaf extract on cytokines production and modulation.
  Matalka KZ, Ali D, Khawad AE, Qa’dan F.Cytokine. 2007 Dec;40(3):235-40. Epub 2007 Nov 26.
• 13. Pharmacological studies on anti-hyperglycemic effect of folium eriobotryae.
  Li WL, Wu JL, Ren BR, Chen J, Lu CG.Am J Chin Med. 2007;35(4):705-11.
• 14. [Study on the use of ultrasound technique in extraction of polysaccharides from Loquat leaf].
  Wang MY, Xu RB, He JX.Zhong Yao Cai. 2006 Nov;29(11):1230-3. Chinese.
• 15. [Determination of corosolic acid in Eriobotrya japonica leaves by reversed-phase high performance liquid chromatography].
  Hu C, Chen L, Xin Y, Cai Q.Se Pu. 2006 Sep;24(5):492-4. Chinese.
• 16. Screening of traditional antidiabetic medicinal plants of Mauritius for possible alpha-amylase inhibitory effects in vitro.
  Kotowaroo MI, Mahomoodally MF, Gurib-Fakim A, Subratty AH.Phytother Res. 2006 Mar;20(3):228-31.
• 17. Anti-inflammatory and antitumor-promoting effects of the triterpene acids from the leaves of Eriobotrya japonica.
  Banno N, Akihisa T, Tokuda H, Yasukawa K, Taguchi Y, Akazawa H, Ukiya M, Kimura Y, Suzuki T, Nishino H.Biol Pharm Bull. 2005 Oct;28(10):1995-9.
• 18. Effects of combination of Caiapo with other plant-derived substance on anti-diabetic efficacy in KK-Ay mice.
  Sakuramata Y, Oe H, Kusano S, Aki O.Biofactors. 2004;22(1-4):149-52.
• 19. The effect of Eriobotrya japonica seed extract on oxidative stress in adriamycin-induced nephropathy in rats.
  Hamada A, Yoshioka S, Takuma D, Yokota J, Cui T, Kusunose M, Miyamura M, Kyotani S, Nishioka Y.Biol Pharm Bull. 2004 Dec;27(12):1961-4.
• 20. Toxic myopathy induced by the ingestion of loquat leaf extract.
  Saliba WR, Goldstein LH, Habib GS, Elias MS.Ann Rheum Dis. 2004 Oct;63(10):1355-6. No abstract available.