Botanical Ingredient

Magnolol Safety Tips

Handling of Magnolol should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. [The relationship between the quality and the leaf shape of magnolia officinalis produced in Hubei enshi].
  Yang HB, Shi L, Yu JJ, Li MM.Zhong Yao Cai. 2012 Jul;35(7):1036-9. Chinese.
• 2. Comparative Inhibitory Effects of Magnolol, Honokiol, Eugenol and bis-Eugenol on Cyclooxygenase-2 Expression and Nuclear Factor-Kappa B Activation in RAW264.7 Macrophage-like Cells Stimulated with Fimbriae of Porphyromonas gingivalis.
  Murakami Y, Kawata A, Seki Y, Koh T, Yuhara K, Maruyama T, Machino M, Ito S, Kadoma Y, Fujisawa S.In Vivo. 2012 Nov;26(6):941-50.
• 3. Magnolol inhibits lipopolysaccharide-induced inflammatory response by interfering with TLR4 mediated NF-κB and MAPKs signaling pathways.
  Fu Y, Liu B, Zhang N, Liu Z, Liang D, Li F, Cao Y, Feng X, Zhang X, Yang Z.J Ethnopharmacol. 2012 Nov 2. doi:pii: S0378-8741(12)00748-9.  10.1016/j.jep.2012.10.051. [Epub ahead of print]
• 4. Study on Spectrum-Effect Relationship of Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Aurantii Immaturus and their Formula.
  Xie RF, Zhou X, Shi ZN, Li YM, Li ZC.J Chromatogr Sci. 2012 Oct 31. [Epub ahead of print]
• 5. Modulation of P-glycoprotein expression by honokiol, magnolol and 4-O-methylhonokiol, the bioactive components of Magnolia officinalis.
  Han HK, Van Anh LT.Anticancer Res. 2012 Oct;32(10):4445-52.
• 6. Protective effect of magnolol on lipopolysaccharide-induced acute lung injury in mice.
  Ni YF, Jiang T, Cheng QS, Gu ZP, Zhu YF, Zhang ZP, Wang J, Yan XL, Wang WP, Ke CK, Han Y, Li XF.Inflammation. 2012 Dec;35(6):1860-6. doi: 10.1007/s10753-012-9507-9.
• 7. Magnolol-induced apoptosis in HCT-116 colon cancer cells is associated with the AMP-activated protein kinase signaling pathway.
  Park JB, Lee MS, Cha EY, Lee JS, Sul JY, Song IS, Kim JY.Biol Pharm Bull. 2012;35(9):1614-20.
• 8. Effect of formula compatibility on the pharmacokinetics of components from Dachengqi Decoction () in rats.
  Gong HL, Tang WF, Wang J, Chen GY, Huang X.Chin J Integr Med. 2012 Sep;18(9):708-13. doi: 10.1007/s11655-012-1205-9. Epub 2012 Aug 31.
• 9. The absorption and transport of magnolol in Caco-2 cell model.
  Wu AG, Zeng B, Huang MQ, Li SM, Chen JN, Lai XP.Chin J Integr Med. 2012 Aug 18. [Epub ahead of print]
• 10. Cardiovascular protection of magnolol: cell-type specificity and dose-related effects.
  Ho JH, Hong CY.J Biomed Sci. 2012 Jul 31;19:70. doi: 10.1186/1423-0127-19-70.
• 11. Anti-hepatitis B virus constituents from the stem bark of Streblus asper.
  Li J, Huang Y, Guan XL, Li J, Deng SP, Wu Q, Zhang YJ, Su XJ, Yang RY.Phytochemistry. 2012 Oct;82:100-9. doi: 10.1016/j.phytochem.2012.06.023. Epub 2012 Jul 18.
• 12. Magnolol reduces glutamate-induced neuronal excitotoxicity and protects against permanent focal cerebral ischemia for up to 4 hours.
  Lee WT, Lin MH, Lee EJ, Hung YC, Tai SH, Chen HY, Chen TY, Wu TS.PLoS One. 2012;7(7):e39952. doi: 10.1371/journal.pone.0039952. Epub 2012 Jul 9.
• 13. Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, induces sleep via the benzodiazepine site of GABA(A) receptor in mice.
  Chen CR, Zhou XZ, Luo YJ, Huang ZL, Urade Y, Qu WM.Neuropharmacology. 2012 Nov;63(6):1191-9. doi: 10.1016/j.neuropharm.2012.06.031. Epub 2012 Jul 4.
• 14. The antiplatelet activity of magnolol is mediated by PPAR-β/γ.
  Shih CY, Chou TC.Biochem Pharmacol. 2012 Sep 15;84(6):793-803. doi: 10.1016/j.bcp.2012.06.022. Epub 2012 Jun 29.
• 15. The effect of magnolol on the Toll-like receptor 4/nuclear factor kappa B signaling pathway in lipopolysaccharide-induced acute lung injury in mice.
  Yunhe F, Bo L, Xiaosheng F, Fengyang L, Dejie L, Zhicheng L, Depeng L, Yongguo C, Xichen Z, Naisheng Z, Zhengtao Y.Eur J Pharmacol. 2012 Aug 15;689(1-3):255-61. doi: 10.1016/j.ejphar.2012.05.038. Epub 2012 Jun 7.
• 16. Honokiol and magnolol stimulate glucose uptake by activating PI3K-dependent Akt in L6 myotubes.
  Choi SS, Cha BY, Lee YS, Yonezawa T, Teruya T, Nagai K, Woo JT.Biofactors. 2012 Sep-Oct;38(5):372-7. doi: 10.1002/biof.1029. Epub 2012 Jun 7.
• 17. Magnolol Protects against MPTP/MPP(+)-Induced Toxicity via Inhibition of Oxidative Stress in In Vivo and In Vitro Models of Parkinson’s Disease.
  Muroyama A, Fujita A, Lv C, Kobayashi S, Fukuyama Y, Mitsumoto Y.Parkinsons Dis. 2012;2012:985157. doi: 10.1155/2012/985157. Epub 2012 May 8.
• 18. Ethanol Extract of Magnolia officinalis Prevents Lipopolysaccharide-Induced Memory Deficiency via Its Antineuroinflammatory and Antiamyloidogenic Effects.
  Lee YJ, Choi DY, Yun YP, Han SB, Kim HM, Lee K, Choi SH, Yang MP, Jeon HS, Jeong JH, Oh KW, Hong JT.Phytother Res. 2012 May 25. doi: 10.1002/ptr.4740. [Epub ahead of print]
• 19. Potent and selective inhibition of magnolol on catalytic activities of UGT1A7 and 1A9.
  Zhu L, Ge G, Liu Y, He G, Liang S, Fang Z, Dong P, Cao Y, Yang L.Xenobiotica. 2012 Oct;42(10):1001-8. doi: 10.3109/00498254.2012.681814. Epub 2012 May 16.
• 20. Wnt/β-catenin signaling mediates the antitumor activity of magnolol in colorectal cancer cells.
  Kang YJ, Park HJ, Chung HJ, Min HY, Park EJ, Lee MA, Shin Y, Lee SK.Mol Pharmacol. 2012 Aug;82(2):168-77. doi: 10.1124/mol.112.078535. Epub 2012 May 1.

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