Standard Herbal Extract

Motherwort Extract Safety Tips

Handling of Motherwort Extract should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Evaluation of the effect of hydroxypropyl-β-cyclodextrin on topical administration of milk thistle extract.
  Spada G, Gavini E, Cossu M, Rassu G, Carta A, Giunchedi P.Carbohydr Polym. 2013 Jan 30;92(1):40-7. doi: 10.1016/j.carbpol.2012.09.018. Epub 2012 Sep 16.
• 2. Absolute Configuration of Isosilybin A by X-ray Crystallography of the Heavy Atom Analogue 7-(4-Bromobenzoyl)isosilybin A.
  Sy-Cordero AA, Day CS, Oberlies NH.J Nat Prod. 2012 Nov 1. [Epub ahead of print]
• 3. Absorption and metabolism of milk thistle flavanolignans in humans.
  Calani L, Brighenti F, Bruni R, Del Rio D.Phytomedicine. 2012 Dec 15;20(1):40-6. doi: 10.1016/j.phymed.2012.09.004. Epub 2012 Oct 13.
• 4. Silymarin for HCV infection.
  Polyak SJ, Oberlies NH, Pécheur EI, Ferenci P, Pawlotsky JM.Antivir Ther. 2012 Sep 24. doi: 10.3851/IMP2402. [Epub ahead of print]
• 5. Silibinin Regulates Matrix Metalloproteinase 3 (Stromelysine1) Gene Expression, Hexoseamines and Collagen Production During Rat Skin Wound Healing.
  Tabandeh MR, Oryan A, Mohhammad-Alipour A, Tabatabaei-Naieni A.Phytother Res. 2012 Sep 13. doi: 10.1002/ptr.4839. [Epub ahead of print]
• 6. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial.
  Fried MW, Navarro VJ, Afdhal N, Belle SH, Wahed AS, Hawke RL, Doo E, Meyers CM, Reddy KR; Silymarin in NASH and C Hepatitis (SyNCH) Study Group.JAMA. 2012 Jul 18;308(3):274-82. doi: 10.1001/jama.2012.8265.
• 7. A sensitive LC-MS/MS assay for the simultaneous analysis of the major active components of silymarin in human plasma.
  Brinda BJ, Zhu HJ, Markowitz JS.J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Aug 1;902:1-9. doi: 10.1016/j.jchromb.2012.06.003. Epub 2012 Jun 12.
• 8. Angiopreventive efficacy of pure flavonolignans from milk thistle extract against prostate cancer: targeting VEGF-VEGFR signaling.
  Deep G, Gangar SC, Rajamanickam S, Raina K, Gu M, Agarwal C, Oberlies NH, Agarwal R.PLoS One. 2012;7(4):e34630. doi: 10.1371/journal.pone.0034630. Epub 2012 Apr 13.
• 9. Occurrence of aflatoxins in milk thistle herbal supplements.
  Tournas VH, Sapp C, Trucksess MW.Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2012;29(6):994-9. doi: 10.1080/19440049.2012.664788. Epub 2012 Mar 23.
• 10. [Effects of the mixture of Swertia pseudochinensis Hara and Silybum marianum Gaertn extracts on CCl(4)-induced liver injury in rats with non-alcoholic fatty liver disease].
  Mao ZM, Song HY, Yang LL, Liu T, Li DF, Zheng PY, Liu P, Ji G.Zhong Xi Yi Jie He Xue Bao. 2012 Feb;10(2):193-9. Chinese.
• 11. Anti-inflammatory/anti-fibrotic effects of the hepatoprotective silymarin and the schistosomicide praziquantel against Schistosoma mansoni-induced liver fibrosis.
  El-Lakkany NM, Hammam OA, El-Maadawy WH, Badawy AA, Ain-Shoka AA, Ebeid FA.Parasit Vectors. 2012 Jan 11;5:9. doi: 10.1186/1756-3305-5-9.
• 12. Metabolic effects of silibinin in the rat liver.
  Colturato CP, Constantin RP, Maeda AS Jr, Constantin RP, Yamamoto NS, Bracht A, Ishii-Iwamoto EL, Constantin J.Chem Biol Interact. 2012 Jan 25;195(2):119-32. doi: 10.1016/j.cbi.2011.11.006. Epub 2011 Nov 25.
• 13. The effects of milk thistle on hepatic fibrosis due to methotrexate in rat.
  Ghaffari AR, Noshad H, Ostadi A, Ghojazadeh M, Asadi P.Hepat Mon. 2011 Jun;11(6):464-8.
• 14. Silymarin prevents the toxicity induced by benzo(a)pyrene in human erythrocytes by preserving its membrane integrity: An in vitro study.
  Kiruthiga P, Karutha Pandian S, Pandima Devi K.Environ Toxicol. 2011 Nov 3. doi: 10.1002/tox.20783. [Epub ahead of print]
• 15. A new approach to enhance oral bioavailability of Silybum Marianum dry extract: association of mechanochemical activation and spray congealing.
  Passerini N, Perissutti B, Albertini B, Franceschinis E, Lenaz D, Hasa D, Locatelli I, Voinovich D.Phytomedicine. 2012 Jan 15;19(2):160-8. doi: 10.1016/j.phymed.2011.06.027. Epub 2011 Jul 30.
• 16. Toxicology and carcinogenesis studies of milk thistle extract (CAS No. 84604-20-6) in F344/N rats and B6C3F1 mice (Feed Studies).
  National Toxicology Program.Natl Toxicol Program Tech Rep Ser. 2011 May;(565):1-177. Review.
• 17. Evidence for differences in regioselective and stereoselective glucuronidation of silybin diastereomers from milk thistle (Silybum marianum) by human UDP-glucuronosyltransferases.
  Jan?ová P, Siller M, Anzenbacherová E, K?en V, Anzenbacher P, Simánek V.Xenobiotica. 2011 Sep;41(9):743-51. doi: 10.3109/00498254.2011.573017. Epub 2011 Apr 27.
• 18. Effects of long-term silymarin oral supplementation on the blood biochemical profile of rainbow trout (Oncorhynchus mykiss).
  Banaee M, Sureda A, Mirvaghefi AR, Rafei GR.Fish Physiol Biochem. 2011 Dec;37(4):885-96. doi: 10.1007/s10695-011-9486-z. Epub 2011 Apr 26.
• 19. [Development of a new HPLC technique for analyzing monosaccharide composition and its application in the quality control of Silybum marianum polysaccharide].
  Tian LM, Qiu XM, Pan ZJ, Lü Y, Yang XB.Yao Xue Xue Bao. 2010 Apr;45(4):498-504. Chinese.
• 20. Investigating the potential for toxicity from long-term use of the herbal products, goldenseal and milk thistle.
  Dunnick JK, Singh B, Nyska A, Peckham J, Kissling GE, Sanders JM.Toxicol Pathol. 2011 Feb;39(2):398-409. doi: 10.1177/0192623310394211. Epub 2011 Feb 7.

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