Standard Herbal Extract

Mucuna Pruriens Extract Safety Tips

Handling of Mucuna Pruriens Extract should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Spirocyclic nortriterpenoids with NGF-potentiating activity from the fruits of Leonurus heterophyllus.
  Liu Y, Kubo M, Fukuyama Y.J Nat Prod. 2012 Jul 27;75(7):1353-8. doi: 10.1021/np300287f. Epub 2012 Jun 15.
• 2. Marrubiin, a constituent of Leonotis leonurus, alleviates diabetic symptoms.
  Mnonopi N, Levendal RA, Mzilikazi N, Frost CL.Phytomedicine. 2012 Apr 15;19(6):488-93. doi: 10.1016/j.phymed.2011.12.008. Epub 2012 Feb 10.
• 3. Enhanced antibacterial activities of leonuri herba extracts containing silver nanoparticles.
  Im AR, Han L, Kim ER, Kim J, Kim YS, Park Y.Phytother Res. 2012 Aug;26(8):1249-55. doi: 10.1002/ptr.3683. Epub 2011 Dec 15.
• 4. The cardioprotective effects of marrubiin, a diterpenoid found in Leonotis leonurus extracts.
  Mnonopi N, Levendal RA, Davies-Coleman MT, Frost CL.J Ethnopharmacol. 2011 Oct 31;138(1):67-75. doi: 10.1016/j.jep.2011.08.041. Epub 2011 Aug 25.
• 5. In vivo validation of Aloe ferox (Mill). Elephantorrhiza elephantina Bruch. Skeels. and Leonotis leonurus (L) R. BR as potential anthelminthics and antiprotozoals against mixed infections of gastrointestinal nematodes in goats.
  Maphosa V, Masika PJ.Parasitol Res. 2012 Jan;110(1):103-8. doi: 10.1007/s00436-011-2455-8. Epub 2011 May 24.
• 6. Protective effects of alkaloid extract from Leonurus heterophyllus on cerebral ischemia reperfusion injury by middle cerebral ischemic injury (MCAO) in rats.
  Liang H, Liu P, Wang Y, Song S, Ji A.Phytomedicine. 2011 Jul 15;18(10):811-8. doi: 10.1016/j.phymed.2011.01.020. Epub 2011 Mar 5.
• 7. Labdane-type diterpenoids from Leonurus heterophyllus and their cholinesterase inhibitory activity.
  Hung TM, Luan TC, Vinh BT, Cuong TD, Min BS.Phytother Res. 2011 Apr;25(4):611-4. doi: 10.1002/ptr.3307. Epub 2010 Oct 27.
• 8. Effect of Leonurus cardiaca oil extract in patients with arterial hypertension accompanied by anxiety and sleep disorders.
  Shikov AN, Pozharitskaya ON, Makarov VG, Demchenko DV, Shikh EV.Phytother Res. 2011 Apr;25(4):540-3. doi: 10.1002/ptr.3292. Epub 2010 Sep 13.
• 9. Two new glycosides from Leonurus japonicus.
  Chang JM, Shen CC, Huang YL, Shieh BJ, Chen CC.J Asian Nat Prod Res. 2010 Sep;12(9):740-4. doi: 10.1080/10286020.2010.493712.
• 10. The evaluation of formulations for the preparation of new formula pellets.
  Gajdziok J, Bernatoniene J, Muselík J, Masteiková R, Dvo?á?ková K, Petkeviciute Z, Lazauskas R, Kalveniene Z, Bernatoniene R.Pharm Dev Technol. 2011 Oct;16(5):520-8. doi: 10.3109/10837450.2010.502174. Epub 2010 Jul 22.
• 11. Effect of aqueous extract of Leonotis leonurus (L.) R. Br. leaves in male Wistar rats.
  Oyedemi SO, Yakubu MT, Afolayan AJ.Hum Exp Toxicol. 2010 May;29(5):377-84. doi: 10.1177/0960327110363864. Epub 2010 Mar 1.
• 12. Leonurus sibiricus herb extract suppresses oxidative stress and ameliorates hypercholesterolemia in C57BL/6 mice and TNF-alpha induced expression of adhesion molecules and lectin-like oxidized LDL receptor-1 in human umbilical vein endothelial cells.
  Lee MJ, Lee HS, Park SD, Moon HI, Park WH.Biosci Biotechnol Biochem. 2010;74(2):279-84. Epub 2010 Feb 7.
• 13. Cardiac and electrophysiological effects of primary and refined extracts from Leonurus cardiaca L. (Ph.Eur.).
  Ritter M, Melichar K, Strahler S, Kuchta K, Schulte J, Sartiani L, Cerbai E, Mugelli A, Mohr FW, Rauwald HW, Dhein S.Planta Med. 2010 Apr;76(6):572-82. doi: 10.1055/s-0029-1240602. Epub 2009 Nov 16.
• 14. Correlation between the in vitro iron chelating activity and poly phenol and flavonoid contents of some medicinal plants.
  Ebrahimzadeh MA, Nabavi SM, Nabavi SF.Pak J Biol Sci. 2009 Jun 15;12(12):934-8.
• 15. The comparison of anti-oxidative kinetics in vitro of the fluid extract from maidenhair tree, motherwort and hawthorn.
  Bernatoniene J, Kucinskaite A, Masteikova R, Kalveniene Z, Kasparaviciene G, Savickas A.Acta Pol Pharm. 2009 Jul-Aug;66(4):415-21.
• 16. Cerebral protection of purified Herba Leonuri extract on middle cerebral artery occluded rats.
  Loh KP, Huang SH, Tan BK, Zhu YZ.J Ethnopharmacol. 2009 Sep 7;125(2):337-43. doi: 10.1016/j.jep.2009.05.025. Epub 2009 Jun 2.
• 17. Cytotoxicity of Chinese motherwort (YiMuCao) aqueous ethanol extract is  non-apoptotic and estrogen receptor independent on human breast cancer cells.
  Tao J, Zhang P, Liu G, Yan H, Bu X, Ma Z, Wang N, Wang G, Jia W.J Ethnopharmacol. 2009 Mar 18;122(2):234-9.
• 18. Safety evaluation of the aqueous extract of Leonotis leonurus shoots in rats.
  Maphosa V, Masika P, Adedapo A.Hum Exp Toxicol. 2008 Nov;27(11):837-43. doi: 10.1177/0960327108099533.
• 19. New labdane diterpenes from Leonurus cardiaca.
  Agnihotri VK, Elsohly HN, Smillie TJ, Khan IA, Walker LA.Planta Med. 2008 Aug;74(10):1288-90. doi: 10.1055/s-2008-1081304. Epub 2008 Jul 29.
• 20. [Enriching of total flavonoids from Herba Leonuri with polyamide and macroporous resin].
  Yu DN, Xu DS, Feng Y, Wei HC.Zhongguo Zhong Yao Za Zhi. 2008 Feb;33(3):264-8. Chinese.

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