Botanical Ingredient

Oleuropein Safety Tips

Handling of Oleuropein should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Effects of a polyphenol present in olive oil, oleuropein aglycone, in a murine model of intestinal ischemia/reperfusion injury.
  Campolo M, Di Paola R, Impellizzeri D, Crupi R, Morittu VM, Procopio A, Perri E, Britti D, Peli A, Esposito E, Cuzzocrea S.J Leukoc Biol. 2012 Dec 11. [Epub ahead of print]
• 2. Simple and fast determination of phenolic compounds from different varieties of olive oil by nonaqueous capillary electrophoresis with UV-visible and fluorescence detection.
  Godoy-Caballero Mdel P, Galeano-Díaz T, Isabel Acedo-Valenzuela M.J Sep Sci. 2012 Dec;35(24):3529-39. doi: 10.1002/jssc.201200696.
• 3. Identification of the factors responsible for the in vitro pro-oxidant and cytotoxic activities of the olive polyphenols oleuropein and hydroxytyrosol.
  Odiatou EM, Skaltsounis AL, Constantinou AI.Cancer Lett. 2012 Nov 29. doi:pii: S0304-3835(12)00693-3.  10.1016/j.canlet.2012.11.035. [Epub ahead of print]
• 4. Oleuropein Induces Anti-metastatic Effects in Breast Cancer.
  Hassan ZK, Elamin MH, Daghestani MH, Omer SA, Al-Olayan EM, Elobeid MA, Virk P, Mohammed OB.Asian Pac J Cancer Prev. 2012;13(9):4555-9.
• 5. Oleuropein reduces free fatty acid-induced lipogenesis via lowered extracellular signal-regulated kinase activation in hepatocytes.
  Hur W, Kim SW, Lee YK, Choi JE, Hong SW, Song MJ, Bae SH, Park T, Um SJ, Yoon SK.Nutr Res. 2012 Oct;32(10):778-86. doi: 10.1016/j.nutres.2012.06.017. Epub 2012 Aug 9.
• 6. A metabolite-profiling approach to assess the uptake and metabolism of phenolic compounds from olive leaves in SKBR3 cells by HPLC-ESI-QTOF-MS.
  Quirantes-Piné R, Zurek G, Barrajón-Catalán E, Bäßmann C, Micol V, Segura-Carretero A, Fernández-Gutiérrez A.J Pharm Biomed Anal. 2013 Jan;72:121-6. doi: 10.1016/j.jpba.2012.09.029. Epub 2012 Oct 6.
• 7. A focus on pressure-driven membrane technology in olive mill wastewater reclamation: state of the art.
  Ochando-Pulido JM, Martinez-Ferez A.Water Sci Technol. 2012;66(12):2505-16. doi: 10.2166/wst.2012.506.
• 8. Comprehensive Analysis of Polyphenols in 55 Extra Virgin Olive Oils by HPLC-ECD and Their Correlation with Antioxidant Activities.
  Bayram B, Esatbeyoglu T, Schulze N, Ozcelik B, Frank J, Rimbach G.Plant Foods Hum Nutr. 2012 Oct 16. [Epub ahead of print]
• 9. Oleuropein, an Anti-oxidant Polyphenol Constituent of Olive Promotes α-Secretase Cleavage of the Amyloid Precursor Protein (AβPP).
  Kostomoiri M, Fragkouli A, Sagnou M, Skaltsounis LA, Pelecanou M, Tsilibary EC, Tauzinia AK.Cell Mol Neurobiol. 2012 Oct 7. [Epub ahead of print]
• 10. [Boiling extraction of oleuropein at low temperature and reduced pressure].
  Xie P, Huang L, Zhang C, You F, Wang C, Zhou H.Zhongguo Zhong Yao Za Zhi. 2012 Jul;37(13):1946-51. Chinese.
• 11. Microchip electrophoresis with amperometric detection for a novel determination of phenolic compounds in olive oil.
  Godoy-Caballero Mdel P, Acedo-Valenzuela MI, Galeano-Díaz T, Costa-García A, Fernández-Abedul MT.Analyst. 2012 Nov 7;137(21):5153-60. doi: 10.1039/c2an35844a. Epub 2012 Sep 24.
• 12. Polyphenols from Pistacia lentiscus and Phillyrea latifolia impair the exsheathment of gastro-intestinal nematode larvae.
  Azaizeh H, Halahleh F, Abbas N, Markovics A, Muklada H, Ungar ED, Landau SY.Vet Parasitol. 2013 Jan 16;191(1-2):44-50. doi: 10.1016/j.vetpar.2012.08.016. Epub 2012 Aug 28.
• 13. Influence of harvest year, cultivar and geographical origin on Greek extra virgin olive oils composition: a study by NMR spectroscopy and biometric analysis.
  Agiomyrgianaki A, Petrakis PV, Dais P.Food Chem. 2012 Dec 15;135(4):2561-8. doi: 10.1016/j.foodchem.2012.07.050. Epub 2012 Jul 20.
• 14. Olive phenolic compounds: metabolic and transcriptional profiling during fruit development.
  Alagna F, Mariotti R, Panara F, Caporali S, Urbani S, Veneziani G, Esposto S, Taticchi A, Rosati A, Rao R, Perrotta G, Servili M, Baldoni L.BMC Plant Biol. 2012 Sep 10;12:162. doi: 10.1186/1471-2229-12-162.
• 15. Analytical evaluation of two monovarietal virgin olive oils cultivated in the south of Tunisia: Jemri-Bouchouka and Chemlali-Tataouin cultivars.
  Rigane G, Boukhris M, Bouaaziz M, Sayadi S, Ben Salem R.J Sci Food Agric. 2012 Aug 30. doi: 10.1002/jsfa.5864. [Epub ahead of print]
• 16. Oleuropein supplementation increases urinary noradrenaline and testicular testosterone levels and decreases plasma corticosterone level in rats fed high-protein diet.
  Oi-Kano Y, Kawada T, Watanabe T, Koyama F, Watanabe K, Senbongi R, Iwai K.J Nutr Biochem. 2012 Aug 15. [Epub ahead of print]
• 17. Characterisation and phenolic profiles of two rare olive oils from southern Tunisia: Dhokar and Gemri-Dhokar cultivars.
  Rigane G, Ayadi M, Boukhris M, Sayadi S, Bouaziz M.J Sci Food Agric. 2012 Aug 7. doi: 10.1002/jsfa.5815. [Epub ahead of print]
• 18. Effect of water deficit on leaf phenolic composition, gas exchange, oxidative damage and antioxidant activity of four Greek olive (Olea europaea L.) cultivars.
  Petridis A, Therios I, Samouris G, Koundouras S, Giannakoula A.Plant Physiol Biochem. 2012 Nov;60:1-11. doi: 10.1016/j.plaphy.2012.07.014. Epub 2012 Aug 2.
• 19. Secoiridoids from the stem barks of Fraxinus rhynchophylla with pancreatic lipase inhibitory activity.
  Ahn JH, Shin E, Liu Q, Kim SB, Choi KM, Yoo HS, Hwang BY, Lee MK.Nat Prod Res. 2012 Jul 30. [Epub ahead of print]
• 20. Bioconversion of oleuropein to hydroxytyrosol by lactic acid bacteria.
  Santos MM, Piccirillo C, Castro PM, Kalogerakis N, Pintado ME.World J Microbiol Biotechnol. 2012 Jun;28(6):2435-40. doi: 10.1007/s11274-012-1036-z. Epub 2012 Mar 20.

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