Botanical Ingredient

Osthole Safety Tips

Handling of Osthole should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. [Inhibition effect of osthole on proliferation of rat chondrocytes].
  Ding DF, Wei SP, Li XF, Zhang XG, Zhan HS, Duan TL, Cao YL.Zhong Xi Yi Jie He Xue Bao. 2012 Dec;10(12):1413-8. doi: 10.3736/jcim20121213. Chinese.
• 2. Investigation of the biotransformation of osthole by liquid chromatography/tandem mass spectrometry.
  Li J, Chan W.J Pharm Biomed Anal. 2013 Feb 23;74:156-61. doi: 10.1016/j.jpba.2012.10.018. Epub 2012 Oct 25.
• 3. Osthole relaxes pulmonary arteries through endothelial phosphatidylinositol 3-kinase/Akt-eNOS-NO signaling pathway in rats.
  Yao L, Lu P, Li Y, Yang L, Feng H, Huang Y, Zhang D, Chen J, Zhu D.Eur J Pharmacol. 2012 Dec 7. doi:pii: S0014-2999(12)00988-0.  10.1016/j.ejphar.2012.11.056. [Epub ahead of print]
• 4. Antispasmodic effect of osthole and Prangos ferulacea extract on rat uterus smooth muscle motility.
  Sadraei H, Shokoohinia Y, Sajjadi SE, Ghadirian B.Res Pharm Sci. 2012 Jul;7(3):141-9.
• 5. Comparative study of pharmacokinetics and tissue distribution of osthole in rats after oral administration of pure osthole and Libanotis buchtormensis supercritical extract.
  Shi J, Fu Q, Chen W, Yang HP, Liu J, Wang XM, He X.J Ethnopharmacol. 2012 Nov 6. doi:pii: S0378-8741(12)00700-3.  10.1016/j.jep.2012.10.028. [Epub ahead of print]
• 6. Modification of rat model of sciatica induced by lumber disc herniation and the anti-inflammatory effect of osthole given by epidural catheterization.
  Wei M, Mo SL, Nabar NR, Chen Y, Zhang JJ, He QL, Zou XN, Liu XG, Sun LB, Zhou SF.Pharmacology. 2012;90(5-6):251-63. doi: 10.1159/000340023. Epub 2012 Sep 25.
• 7. Pharmacokinetics and tissue distribution study of praeruptorin d from radix peucedani in rats by high-performance liquid chromatography (HPLC).
  Liang T, Yue W, Du X, Ren L, Li Q.Int J Mol Sci. 2012;13(7):9129-41. doi: 10.3390/ijms13079129. Epub 2012 Jul 20.
• 8. Osthole suppresses migration and invasion of A549 human lung cancer cells through inhibition of matrix metalloproteinase-2 and matrix metallopeptidase-9             in vitro.
  Xu XM, Zhang Y, Qu D, Feng XW, Chen Y, Zhao L.Mol Med Report. 2012 Nov;6(5):1018-22. doi: 10.3892/mmr.2012.1044. Epub 2012 Aug 21.
• 9. Reduction of rat cardiac hypertrophy by osthol is related to regulation of cardiac oxidative stress and lipid metabolism.
  Zhou F, Zhong W, Xue J, Gu ZL, Xie ML.Lipids. 2012 Oct;47(10):987-94. Epub 2012 Aug 24.
• 10. Osthole attenuates focal inflammatory reaction following permanent middle cerebral artery occlusion in rats.
  Li F, Gong Q, Wang L, Shi J.Biol Pharm Bull. 2012;35(10):1686-90. Epub 2012 Aug 8.
• 11. Bioactive constituents of Clausena lansium and a method for discrimination of aldose enantiomers.
  Shen DY, Chao CH, Chan HH, Huang GJ, Hwang TL, Lai CY, Lee KH, Thang TD, Wu TS.Phytochemistry. 2012 Oct;82:110-7. doi: 10.1016/j.phytochem.2012.06.019. Epub 2012 Jul 18.
• 12. Synthesis and anthelmintic activity of osthol analogs against Dactylogyrus intermedius in goldfish.
  Liu GL, Hao B, Liu SP, Wang GX.Eur J Med Chem. 2012 Aug;54:582-90. doi: 10.1016/j.ejmech.2012.06.009. Epub 2012 Jun 15.
• 13. Growth inhibition and apoptosis induced by osthole, a natural coumarin, in hepatocellular carcinoma.
  Zhang L, Jiang G, Yao F, He Y, Liang G, Zhang Y, Hu B, Wu Y, Li Y, Liu H.PLoS One. 2012;7(5):e37865. doi: 10.1371/journal.pone.0037865. Epub 2012 May 25.
• 14. Osthole, a herbal compound, alleviates nucleus pulposus-evoked nociceptive responses through the suppression of overexpression of acid-sensing ion channel 3 (ASIC3) in rat dorsal root ganglion.
  He QL, Chen Y, Qin J, Mo SL, Wei M, Zhang JJ, Li MN, Zou XN, Zhou SF, Chen XW, Sun LB.Med Sci Monit. 2012 Jun;18(6):BR229-36.
• 15. Isolation and identification of metabolites of osthole in rats.
  Lv X, Wang CY, Hou J, Zhang BJ, Deng S, Tian Y, Huang SS, Zhang HL, Shu XH, Zhen YH, Liu KX, Yao JH, Ma XC.Xenobiotica. 2012 Nov;42(11):1120-7. doi: 10.3109/00498254.2012.689887. Epub 2012 May 26.
• 16. [Effect of osthol on apoptosis and bone resorption of osteoclasts cultured in vitro].
  Ming LG, Wang MG, Chen KM, Zhou J, Han GQ, Zhu RQ.Yao Xue Xue Bao. 2012 Feb;47(2):174-9. Chinese.
• 17. Osthole inhibits the invasive ability of human lung adenocarcinoma cells via suppression of NF-κB-mediated matrix metalloproteinase-9 expression.
  Kao SJ, Su JL, Chen CK, Yu MC, Bai KJ, Chang JH, Bien MY, Yang SF, Chien MH.Toxicol Appl Pharmacol. 2012 May 15;261(1):105-15. doi: 10.1016/j.taap.2012.03.020. Epub 2012 Apr 4.
• 18. Larvicidal activity of Cnidium monnieri fruit coumarins and structurally related compounds against insecticide-susceptible and insecticide-resistant Culex pipiens pallens and Aedes aegypti.
  Wang Z, Kim JR, Wang M, Shu S, Ahn YJ.Pest Manag Sci. 2012 Jul;68(7):1041-7. doi: 10.1002/ps.3265. Epub 2012 Mar 5.
• 19. Analysis of herbal dietary supplements for sexual performance enhancement: first characterization of propoxyphenyl-thiohydroxyhomosildenafil and identification of sildenafil, thiosildenafil, phentolamine and tetrahydropalmatine as adulterants.
  Balayssac S, Gilard V, Zedde C, Martino R, Malet-Martino M.J Pharm Biomed Anal. 2012 Apr 7;63:135-50. doi: 10.1016/j.jpba.2012.01.035. Epub 2012 Feb 4.
• 20. Aliphatic esters as targets of esterase activity in the parsnip webworm (Depressaria pastinacella).
  Zangerl AR, Liao LH, Jogesh T, Berenbaum MR.J Chem Ecol. 2012 Feb;38(2):188-94. doi: 10.1007/s10886-012-0073-2. Epub 2012 Feb 16.

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