Botanical Ingredient

Oxymatrine Safety Tips

Handling of Oxymatrine should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Neuroprotective effects of oxymatrine against excitotoxicity partially through down-regulation of NR2B-containing NMDA receptors.
  Zhang K, Li YJ, Yang Q, Gerile O, Yang L, Li XB, Guo YY, Zhang N, Feng B, Liu SB, Zhao MG.Phytomedicine. 2012 Dec 5. doi:pii: S0944-7113(12)00409-6.  10.1016/j.phymed.2012.10.018. [Epub ahead of print]
• 2. Effect of oxymatrine, the active component from Radix Sophorae flavescentis (Kushen), on ventricular remodeling in spontaneously hypertensive rats.
  Huang XY, Chen CX.Phytomedicine. 2012 Dec 1. doi:pii: S0944-7113(12)00378-9.  10.1016/j.phymed.2012.10.012. [Epub ahead of print]
• 3. Effects of oxymatrine on the neuropathic pain induced by chronic constriction injury in mice.
  Liu HY, Li YX, Hao YJ, Wang HY, Dai XY, Sun T, Yu JQ.CNS Neurosci Ther. 2012 Dec;18(12):1030-2. doi: 10.1111/cns.12026. Epub 2012 Nov 16. No abstract is available.
• 4. [Effects of oxymatrine on the expressions of pro-collagen and fibronectin of fibroblats derived from human hyperplastic scars].
  Bian X, Wu JQ, Nie XJ.Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 Oct;32(10):1390-3. Chinese.
• 5. Kinetics and Computational Docking Studies on the Inhibition of Tyrosinase Induced by Oxymatrine.
  Liu XX, Sun SQ, Wang YJ, Xu W, Wang YF, Park D, Zhou HM, Han HY.Appl Biochem Biotechnol. 2012 Nov 17. [Epub ahead of print]
• 6. Arsenic trioxide-induced hERG K(+) channel deficiency can be rescued by matrine and oxymatrine through up-regulating transcription factor Sp1 expression.
  Zhang Y, Dong Z, Jin L, Zhang K, Zhao X, Fu J, Gong Y, Sun M, Yang B, Li B.Biochem Pharmacol. 2012 Oct 24. doi:pii: S0006-2952(12)00611-9.  10.1016/j.bcp.2012.09.002. [Epub ahead of print]
• 7. Human ether-a-go-go-Related Gene Channel Blockers and Its Structural Analysis for Drug Design.
  Moorthy NS, Ramos MJ, Fernandes PA.Curr Drug Targets. 2012 Oct 8. [Epub ahead of print]
• 8. [Pharmacokinetic of four alkaloids of Yanshu injection in Beagel dogs].
  Liu J, Xue M, Huang X, Wang S, Jiang Z, Zhang L.Zhongguo Zhong Yao Za Zhi. 2012 Jun;37(12):1845-9. Chinese.
• 9. Antitumor activities of kushen: literature review.
  Sun M, Cao H, Sun L, Dong S, Bian Y, Han J, Zhang L, Ren S, Hu Y, Liu C, Xu L, Liu P.Evid Based Complement Alternat Med. 2012;2012:373219. doi: 10.1155/2012/373219. Epub 2012 Aug 28.
• 10. Oxymatrine liposome attenuates hepatic fibrosis via targeting hepatic stellate cells.
  Chai NL, Fu Q, Shi H, Cai CH, Wan J, Xu SP, Wu BY.World J Gastroenterol. 2012 Aug 21;18(31):4199-206. doi: 10.3748/wjg.v18.i31.4199.
• 11. Development of an osmotically-driven pellet coated with acrylic copolymers (Eudragit® RS 30 D) for the sustained release of oxymatrine, a freely water soluble drug used to treat stress ulcers (I): in vitro and in vivo evaluation in rabbits.
  Piao H, Liu S, Piao H, Li X, Cui F.Drug Dev Ind Pharm. 2012 Aug 9. [Epub ahead of print]
• 12. Effect of oxymatrine on hepatic gene expression profile in experimental liver fibrosis of rats.
  Jian YC, Li W, He Y, Jiang M, Liu YB, Xiong WJ.Chin J Integr Med. 2012 Jun;18(6):445-50. doi: 10.1007/s11655-012-1115-x. Epub 2012 Jul 22.
• 13. Screening for the efficacy of lipid accumulation in 3T3-L1 cells is an effective tool for the identification of new anti-diabetic compounds.
  Zeng XY, Zhou X, Xu J, Chan SM, Xue CL, Molero JC, Ye JM.Biochem Pharmacol. 2012 Sep 15;84(6):830-7. doi: 10.1016/j.bcp.2012.07.003. Epub 2012 Jul 20.
• 14. Observation of antinociceptive effects of oxymatrine and its effect on delayed rectifier K? currents (Ik) in PC12 cells.
  Wang Y, Yuan J, Yuan X, Wang W, Pei X, Zhao Q, Cao H, Xu M, Liu Z.Neurochem Res. 2012 Oct;37(10):2143-9. doi: 10.1007/s11064-012-0836-8. Epub 2012 Jul 20.
• 15. [Effect of oxymatrine on vascular calcification of humans umbilical vein smooth muscle cells and its underlying mechanism].
  Wang X, Zhang J, Zhang M, Liu S, Li G, Cao J.Zhongguo Zhong Yao Za Zhi. 2012 Apr;37(7):1002-6. Chinese.
• 16. [Simultaneous determination of 7 alkaloid in herba Sophorae Alopecuroidis by HPLC].
  Ma L, Wang J, Tian J, Wang K, Li W, Wang Y.Zhongguo Zhong Yao Za Zhi. 2011 Jun;36(11):1483-6. Chinese.
• 17. Role of β2-adrenoceptor-β-arrestin2-nuclear factor-κB signal transduction pathway and intervention effects of oxymatrine in ulcerative colitis.
  Fan H, Liao Y, Tang Q, Chen XY, Zhang LJ, Liu XX, Zhong M.Chin J Integr Med. 2012 Jul;18(7):514-21. doi: 10.1007/s11655-012-1146-3. Epub 2012 Jul 7.
• 18. The protective role of oxymatrine on neuronal cell apoptosis in the hemorrhagic rat brain.
  Huang M, Hu YY, Dong XQ, Xu QP, Yu WH, Zhang ZY.J Ethnopharmacol. 2012 Aug 30;143(1):228-35. doi: 10.1016/j.jep.2012.06.028. Epub 2012 Jun 28.
• 19. Matrine- and oxymatrine-imprinted monodisperse polymers prepared by precipitation polymerization and their applications for the selective extraction of matrine-type alkaloids from Sophora flavescens Aiton.
  Funaya N, Haginaka J.J Chromatogr A. 2012 Jul 27;1248:18-23. doi: 10.1016/j.chroma.2012.05.081. Epub 2012 May 29.
• 20. [Protective effect of TGF-beta-Smads signal-based oxymatrine on myocardial fibrosis induced by acute myocardial infarction in rats].
  Shen X, Yang Y, Xu Y, Xu L, Fang T.Zhongguo Zhong Yao Za Zhi. 2012 Mar;37(5):632-6. Chinese.

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