Standard Herbal Extract

Persimmon Leaf Extract Safety Tips

Handling of Persimmon Leaf Extract should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Nuclear Factor-κB: central regulator in ocular surface inflammation and diseases.
  Lan W, Petznick A, Heryati S, Rifada M, Tong L.Ocul Surf. 2012 Jul;10(3):137-48. doi: 10.1016/j.jtos.2012.04.001. Epub 2012 Apr 30. Review.
• 2. Isolation, identification, and biological evaluation of Nrf2-ARE activator from the leaves of green perilla (Perilla frutescens var. crispa f. viridis).
  Izumi Y, Matsumura A, Wakita S, Akagi K, Fukuda H, Kume T, Irie K, Takada-Takatori Y, Sugimoto H, Hashimoto T, Akaike A.Free Radic Biol Med. 2012 Aug 15;53(4):669-79. doi: 10.1016/j.freeradbiomed.2012.06.021. Epub 2012 Jun 27.
• 3. Optimization of Antibacterial Activity of Perilla frutescens var. acuta Leaf against Staphylococcus aureus Using Evolutionary Operation Factorial Design Technique.
  Kim DH, Kim YC, Choi UK.Int J Mol Sci. 2011;12(4):2395-407. doi: 10.3390/ijms12042395. Epub 2011 Apr 6.
• 4. Separation of anthocyanins from Perilla frutescens by high speed countercurrent chromatography.
  Hu XD, Sun AD, Zhang DQ.Zhong Yao Cai. 2010 Oct;33(10):1586-8.
• 5. Effect of Perilla frutescens var. acuta Kudo and rosmarinic acid on allergic inflammatory reactions.
  Oh HA, Park CS, Ahn HJ, Park YS, Kim HM.Exp Biol Med (Maywood). 2011 Jan;236(1):99-106. doi: 10.1258/ebm.2010.010252.
• 6. Optimization of Antibacterial Activity of Perilla frutescens var. acuta Leaf against Pseudomonas aeruginosa Using the Evolutionary Operation-Factorial Design Technique.
  Choi UK, Lee OH, Lim SI, Kim YC.Int J Mol Sci. 2010 Oct 14;11(10):3922-32. doi: 10.3390/ijms11103922.
• 7. Perilla leaf, Perilla frutescens, induces apoptosis and G1 phase arrest in human leukemia HL-60 cells through the combinations of death receptor-mediated, mitochondrial, and endoplasmic reticulum stress-induced pathways.
  Kwak CS, Yeo EJ, Moon SC, Kim YW, Ahn HJ, Park SC.J Med Food. 2009 Jun;12(3):508-17. doi: 10.1089/jmf.2008.1103.
• 8. Perilla leaf extract ameliorates obesity and dyslipidemia induced by high-fat diet.
  Kim MJ, Kim HK.Phytother Res. 2009 Dec;23(12):1685-90. doi: 10.1002/ptr.2811.
• 9. Beta-secretase (BACE1) inhibitors from Perilla frutescens var. acuta.
  Choi SH, Hur JM, Yang EJ, Jun M, Park HJ, Lee KB, Moon E, Song KS.Arch Pharm Res. 2008 Feb;31(2):183-7.
• 10. Growth inhibitory and apoptosis inducing effect of Perilla frutescens extract on human hepatoma HepG2 cells.
  Lin CS, Kuo CL, Wang JP, Cheng JS, Huang ZW, Chen CF.J Ethnopharmacol. 2007 Jul 25;112(3):557-67. Epub 2007 May 10.
• 11. Protective effect of aqueous extract of Perilla frutescens on tert-butyl hydroperoxide-induced oxidative hepatotoxicity in rats.
  Kim MK, Lee HS, Kim EJ, Won NH, Chi YM, Kim BC, Lee KW.Food Chem Toxicol. 2007 Sep;45(9):1738-44. Epub 2007 Mar 18.
• 12. [Case of drug-induced pneumonitis associated with a dietary supplement containing CoQ10].
  Nishino M, Usami M, Sugimura S, Yoshizaki S.Nihon Kokyuki Gakkai Zasshi. 2006 Oct;44(10):766-70. Japanese.
• 13. Anthocyanin and flavonoid production from Perilla frutescens: pilot plant scale processing including cross-flow microfiltration and reverse osmosis.
  Meng L, Lozano Y, Bombarda I, Gaydou E, Li B.J Agric Food Chem. 2006 Jun 14;54(12):4297-303.
• 14. [The influence of common perilla (Perilla frutescens (L.) Britton) on non-specific cell-mediated immunity–phagocytosis activity].
  Simoniene G, Jurkstiene V, Jankauskiene K, Gailys V, Kevelaitis E, Venskutonis PR.Medicina (Kaunas). 2005;41(12):1042-7. Lithuanian.
• 15. Effects of volatile constituents of a rosemary extract on allergic airway inflammation related to house dust mite allergen in mice.
  Inoue K, Takano H, Shiga A, Fujita Y, Makino H, Yanagisawa R, Ichinose T, Kato Y, Yamada T, Yoshikawa T.Int J Mol Med. 2005 Aug;16(2):315-9.
• 16. Rosmarinic acid in perilla extract inhibits allergic inflammation induced by mite allergen, in a mouse model.
  Sanbongi C, Takano H, Osakabe N, Sasa N, Natsume M, Yanagisawa R, Inoue KI, Sadakane K, Ichinose T, Yoshikawa T.Clin Exp Allergy. 2004 Jun;34(6):971-7.
• 17. Inhibitory effect of Perilla leaf extract and luteolin on mouse skin tumor promotion.
  Ueda H, Yamazaki C, Yamazaki M.Biol Pharm Bull. 2003 Apr;26(4):560-3.
• 18. Anti-allergic effect of Perilla frutescens and its active constituents.
  Makino T, Furuta Y, Wakushima H, Fujii H, Saito K, Kano Y.Phytother Res. 2003 Mar;17(3):240-3.
• 19. Luteolin is an anti-inflammatory and anti-allergic constituent of Perilla frutescens.
  Ueda H, Yamazaki C, Yamazaki M.Biol Pharm Bull. 2002 Sep;25(9):1197-202.
• 20. Effect of Perilla frutescens on nitric oxide production and DNA synthesis in cultured murine vascular smooth muscle cells.
  Makino T, Ono T, Muso E, Honda G.Phytother Res. 2002 Mar;16 Suppl 1:S19-23.