Standard Herbal Extract

Plumbago Zeylanica Root Extract Safety Tips

Handling of Plumbago Zeylanica Root Extract should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Anti-inflammatory properties of fruit juices enriched with pine bark extract in an in vitro model of inflamed human intestinal epithelium: The effect of gastrointestinal digestion.
  Frontela-Saseta C, López-Nicolás R, González-Bermúdez CA, Martínez-Graciá C, Ros-Berruezo G.Food Chem Toxicol. 2012 Dec 5. doi:pii: S0278-6915(12)00831-9.  10.1016/j.fct.2012.11.024. [Epub ahead of print]
• 2. A Natural Antioxidant Pine Bark Extract, Oligopin®, Regulates the Stress Chaperone HSPB1 in Human Skeletal Muscle Cells: A Proteomics Approach.
  Poussard S, Pires-Alves A, Diallo R, Dupuy JW, Dargelos E.Phytother Res. 2012 Nov 28. doi: 10.1002/ptr.4895. [Epub ahead of print]
• 3. Production, composition, and toxicology studies of Enzogenol®Pinus radiata bark extract.
  Frevel MA, Pipingas A, Grigsby WJ, Frampton CM, Gilchrist NL.Food Chem Toxicol. 2012 Dec;50(12):4316-24. doi: 10.1016/j.fct.2012.08.051. Epub 2012 Sep 12.
• 4. Oral administration of French maritime pine bark extract (Flavangenol(®)) improves clinical symptoms in photoaged facial skin.
  Furumura M, Sato N, Kusaba N, Takagaki K, Nakayama J.Clin Interv Aging. 2012;7:275-86. doi: 10.2147/CIA.S33165. Epub 2012 Jul 27.
• 5. Analgesic and Anti-Inflammatory Activity of Pinus roxburghii Sarg.
  Kaushik D, Kumar A, Kaushik P, Rana AC.Adv Pharmacol Sci. 2012;2012:245431. doi: 10.1155/2012/245431. Epub 2012 Jun 14.
• 6. Glucose and blood pressure lowering effects of Pycnogenol® are inefficient to prevent prolongation of QT interval in experimental diabetic cardiomyopathy.
  Jankyova S, Kmecova J, Cernecka H, Mesarosova L, Musil P, Brnoliakova Z, Kyselovic J, Babal P, Klimas J.Pathol Res Pract. 2012 Aug 15;208(8):452-7. doi: 10.1016/j.prp.2012.05.010. Epub 2012 Jun 30.
• 7. Facilitated cellular uptake and suppression of inducible nitric oxide synthase by a metabolite of maritime pine bark extract (Pycnogenol).
  Uhlenhut K, Högger P.Free Radic Biol Med. 2012 Jul 15;53(2):305-13. doi: 10.1016/j.freeradbiomed.2012.04.013. Epub 2012 Apr 23.
• 8. Pycnogenol® (extract of French maritime pine bark) for the treatment of chronic disorders(®) for the treatment of chronic disorders.
  Schoonees A, Visser J, Musekiwa A, Volmink J.Cochrane Database Syst Rev. 2012 Apr 18;4:CD008294. doi: 10.1002/14651858.CD008294.pub4. Review.
• 9. Protective effects of pine bark extract on hexavalent chromium-induced dermatotoxicity in rats.
  Lee IC, Kim SH, Shin IS, Moon C, Park SH, Kim SH, Park SC, Kim HC, Kim JC.Phytother Res. 2012 Oct;26(10):1534-40. doi: 10.1002/ptr.4610. Epub 2012 Feb 17.
• 10. Pycnogenol(®) for the treatment of chronic disorders.
  Schoonees A, Visser J, Musekiwa A, Volmink J.Cochrane Database Syst Rev. 2012 Feb 15;2:CD008294. doi: 10.1002/14651858.CD008294.pub3. Review. Update in: Cochrane Database Syst Rev. 2012;4:CD008294.
• 11. Effects of pitamin on growth performance, carcass characteristics and cecal microflora of broiler chicken.
  Park BS.J Environ Biol. 2011 Sep;32(5):585-90.
• 12. Pycnogenol® effects on skin elasticity and hydration coincide with increased gene expressions of collagen type I and hyaluronic acid synthase in women.
  Marini A, Grether-Beck S, Jaenicke T, Weber M, Burki C, Formann P, Brenden H, Schönlau F, Krutmann J.Skin Pharmacol Physiol. 2012;25(2):86-92. doi: 10.1159/000335261. Epub 2012 Jan 21.
• 13. Effects of Pycnogenol on endothelial function in patients with stable coronary artery disease: a double-blind, randomized, placebo-controlled, cross-over study.
  Enseleit F, Sudano I, Périat D, Winnik S, Wolfrum M, Flammer AJ, Fröhlich GM, Kaiser P, Hirt A, Haile SR, Krasniqi N, Matter CM, Uhlenhut K, Högger P, Neidhart M, Lüscher TF, Ruschitzka F, Noll G.Eur Heart J. 2012 Jul;33(13):1589-97. doi: 10.1093/eurheartj/ehr482. Epub 2012 Jan 11.
• 14. Flavangenol (pine bark extract) and its major component procyanidin B1 enhance fatty acid oxidation in fat-loaded models.
  Shimada T, Tokuhara D, Tsubata M, Kamiya T, Kamiya-Sameshima M, Nagamine R, Takagaki K, Sai Y, Miyamoto K, Aburada M.Eur J Pharmacol. 2012 Feb 29;677(1-3):147-53. doi: 10.1016/j.ejphar.2011.12.034. Epub 2011 Dec 29.
• 15. Supplementation with Pycnogenol® improves signs and symptoms of menopausal transition.
  Errichi S, Bottari A, Belcaro G, Cesarone MR, Hosoi M, Cornelli U, Dugall M, Ledda A, Feragalli B.Panminerva Med. 2011 Sep;53(3 Suppl 1):65-70.
• 16. Pycnogenol® improvements in asthma management.
  Belcaro G, Luzzi R, Cesinaro Di Rocco P, Cesarone MR, Dugall M, Feragalli B, Errichi BM, Ippolito E, Grossi MG, Hosoi M, Errichi S, Cornelli U, Ledda A, Gizzi G.Panminerva Med. 2011 Sep;53(3 Suppl 1):57-64.
• 17. Prevention of post thrombotic syndrome with Pycnogenol® in a twelve month study.
  Errichi BM, Belcaro G, Hosoi M, Cesarone MR, Dugall M, Feragalli B, Bavera P, Hosoi M, Zulli C, Corsi M, Ledda A, Luzzi R, Ricci A.Panminerva Med. 2011 Sep;53(3 Suppl 1):21-7.
• 18. French maritime pine bark extract (Pycnogenol®) and the use of health supplements in the age of personalized medicine.
  Strong JM.Panminerva Med. 2011 Sep;53(3 Suppl 1):1-2. No abstract available.
• 19. Protective effects of pine bark extract on developmental toxicity of cyclophosphamide in rats.
  Kim SH, Lee IC, Lim JH, Moon C, Bae CS, Kim SH, Shin DH, Park SC, Kim HC, Kim JC.Food Chem Toxicol. 2012 Feb;50(2):109-15. doi: 10.1016/j.fct.2011.10.048. Epub 2011 Oct 19.
• 20. Direct assessment by electron spin resonance spectroscopy of the antioxidant effects of French maritime pine bark extract in the maxillofacial region of hairless mice.
  Yoshida A, Yoshino F, Tsubata M, Ikeguchi M, Nakamura T, Lee MC.J Clin Biochem Nutr. 2011 Sep;49(2):79-86. doi: 10.3164/jcbn.10-103. Epub 2011 Jun 3.