Botanical Ingredient

Podophyllotoxin Safety Tips

Handling of Podophyllotoxin should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Therapy of human papillomavirus-related disease.
  Stern PL, van der Burg SH, Hampson IN, Broker TR, Fiander A, Lacey CJ, Kitchener HC, Einstein MH.Vaccine. 2012 Nov 20;30 Suppl 5:F71-82. doi: 10.1016/j.vaccine.2012.05.091.
• 2. Comparison of outcomes in patients treated with multi-agent regiments of cisplatin, adriamycin, and VP-16 versus carboplatin and paclitaxel for advanced and recurrent endometrial cancer.
  Olawaiye AB, Godoy HE, Shahzad MM, Rauh-Hain JA, Lele SB, Odunsi K.Eur J Gynaecol Oncol. 2012;33(5):477-9.
• 3. Next Generation Sequencing in Predicting Gene Function in Podophyllotoxin Biosynthesis.
  Marques JV, Kim KW, Lee C, Costa MA, May GD, Crow JA, Davin LB, Lewis NG.J Biol Chem. 2012 Nov 16. [Epub ahead of print]
• 4. Lignopurines: A new family of hybrids between cyclolignans and purines. Synthesis and biological evaluation.
  Castro MÁ, Miguel Del Corral JM, García PA, Rojo MV, Bento AC, Mollinedo F, Francesch AM, San Feliciano A.Eur J Med Chem. 2012 Dec;58:377-89. doi: 10.1016/j.ejmech.2012.10.026. Epub 2012 Oct 26.
• 5. Protective effects and mechanisms of curcumin on podophyllotoxin toxicity in vitro and in vivo.
  Li J, Dai CX, Sun H, Jin L, Guo CY, Cao W, Wu J, Tian HY, Luo C, Ye WC, Jiang RW.Toxicol Appl Pharmacol. 2012 Dec 1;265(2):190-9. doi: 10.1016/j.taap.2012.10.010. Epub 2012 Oct 23.
• 6. Strucure Activity Relationship of Arylidene  Pyrrolo and Pyrido [2,1-b] Quinazolones as Cytotoxic Agents: Synthesis, SAR Studies,  Biological Evaluation and Docking Studies.
  Mangla V, Nepali K, Singh G, Singh J, Guru S, Gupta MK, Mahajan P, Lal Dhar K.Med Chem. 2012 Oct 5. [Epub ahead of print]
• 7. Adva-27a, a novel podophyllotoxin derivative found to be effective against multidrug resistant human cancer cells.
  Merzouki A, Buschmann MD, Jean M, Young RS, Liao S, Gal S, Li Z, Slilaty SN.Anticancer Res. 2012 Oct;32(10):4423-32.
• 8. [Escalated BEACOPP as an alternative in high risk Hodgkin lymphoma].
  Jurczak W, Krochmalczyk D, Giza A, Sobocinski M, Skotnicki AB.Przegl Lek. 2012;69(5):171-5. Polish.
• 9. [Antiproliferative and cytotoxic effects of different type cytostatics on mouse pluripotent stem and teratocarcinoma cells].
  Gordeeva OF.Ontogenez. 2012 Jul-Aug;43(4):268-77. Russian.
• 10. Synthesis and biological evaluation of a series of podophyllotoxins derivatives as a class of potent antitubulin agents.
  Liu Y, Wei D, Zhao Y, Cheng W, Lu Y, Ma Y, Li X, Han C, Wei Y, Cao H, Zhao C.Bioorg Med Chem. 2012 Nov 1;20(21):6285-95. doi: 10.1016/j.bmc.2012.09.009. Epub 2012 Sep 13.
• 11. Quantification of limonin in human urine using solid-phase extraction by LC-MS/MS.
  Liu S, Zhang J, Zhou L, Yu B, Li C, Liu Z, Ju W.J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Oct 15;907:163-7. doi: 10.1016/j.jchromb.2012.08.038. Epub 2012 Sep 7.
• 12. DNA-PKcs-dependent NHEJ pathway supports the progression of topoisomerase II poison-induced chromosome aberrant cells.
  Elguero ME, de Campos-Nebel M, González-Cid M.Environ Mol Mutagen. 2012 Oct;53(8):608-18. doi: 10.1002/em.21729. Epub 2012 Sep 18.
• 13. Coilin levels modulate cell cycle progression and γH2AX levels in etoposide treated U2OS cells.
  Velma V, Carrero ZI, Allen CB, Hebert MD.FEBS Lett. 2012 Sep 21;586(19):3404-9. doi: 10.1016/j.febslet.2012.07.054. Epub 2012 Aug 7.
• 14. Synthesis, characterization and biological evaluation of some novel 2,4-thiazolidinediones as potential cytotoxic, antimicrobial and antihyperglycemic agents.
  Avupati VR, Yejella RP, Akula A, Guntuku GS, Doddi BR, Vutla VR, Anagani SR, Adimulam LS, Vyricharla AK.Bioorg Med Chem Lett. 2012 Oct 15;22(20):6442-50. doi: 10.1016/j.bmcl.2012.08.052. Epub 2012 Aug 21.
• 15. Young women’s experiences of managing self-treatment for anogenital warts.
  Hammarlund K, Nyström M, Jomeen J.Sex Reprod Healthc. 2012 Oct;3(3):117-21. doi: 10.1016/j.srhc.2012.07.002. Epub 2012 Aug 10.
• 16. Topical treatments for cutaneous warts.
  Kwok CS, Gibbs S, Bennett C, Holland R, Abbott R.Cochrane Database Syst Rev. 2012 Sep 12;9:CD001781. doi: 10.1002/14651858.CD001781.pub3. Review.
• 17. Semi-Synthesis and Biological Evaluation of 1,2,3-Triazole-Based Podophyllotoxin Congeners as Potent Antitumor Agents Inducing Apoptosis in HepG2 Cells.
  Chen J, Ma L, Zhang R, Tang J, Lai H, Wang J, Wang G, Xu Q, Chen T, Peng F, Qiu J, Liang X, Cao D, Ran Y, Peng A, Wei Y, Chen L.Arch Pharm (Weinheim). 2012 Dec;345(12):945-56. doi: 10.1002/ardp.201100438. Epub 2012 Sep 5.
• 18. Ultrahigh pressure extraction of lignan compounds from Dysosma versipellis and purification by high-speed counter-current chromatography.
  Zhu Q, Liu F, Xu M, Lin X, Wang X.J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Sep 15;905:145-9. doi: 10.1016/j.jchromb.2012.08.016. Epub 2012 Aug 21.
• 19. Fatal cases of gestational trophoblastic neoplasia over four decades in the Netherlands: a retrospective cohort study.
  Lybol C, Centen DW, Thomas CM, ten Kate-Booij MJ, Verheijen RH, Sweep FC, Ottevanger PB, Massuger LF.BJOG. 2012 Nov;119(12):1465-72. doi: 10.1111/j.1471-0528.2012.03480.x. Epub 2012 Aug 24.
• 20. Safety and activity of a new intensive short-term chemoimmunotherapy in HIV-positive patients with Burkitt lymphoma.
  Ferreri AJ, Bruno Ventre M, Donadoni G, Cattaneo C, Fumagalli L, Foppoli M, Mappa S, Govi S, Di Nicola M, Rossi G, Tirelli U, Caligaris-Cappio F, Spina M, Re A.Br J Haematol. 2012 Oct;159(2):252-5. doi: 10.1111/bjh.12020. Epub 2012 Aug 25. No abstract available.

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