Botanical Ingredient

Protodioscin Safety Tips

Handling of Protodioscin should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Effects of various asparagus production methods on rutin and protodioscin contents in spears and cladophylls.
  Motoki S, Kitazawa H, Maeda T, Suzuki T, Chiji H, Nishihara E, Shinohara Y.Biosci Biotechnol Biochem. 2012;76(5):1047-50. Epub 2012 May 7.
• 2. Fenugreek with reduced bitterness prevents diet-induced metabolic disorders in rats.
  Muraki E, Chiba H, Taketani K, Hoshino S, Tsuge N, Tsunoda N, Kasono K.Lipids Health Dis. 2012 May 29;11:58. doi: 10.1186/1476-511X-11-58.
• 3. Solanum incanum and S. heteracanthum as sources of biologically active steroid glycosides: confirmation of their synonymy.
  Manase MJ, Mitaine-Offer AC, Pertuit D, Miyamoto T, Tanaka C, Delemasure S, Dutartre P, Mirjolet JF, Duchamp O, Lacaille-Dubois MA.Fitoterapia. 2012 Sep;83(6):1115-9. doi: 10.1016/j.fitote.2012.04.024. Epub 2012 May 2.
• 4. Relative feeding and development of armyworm on switchgrass and corn, and its potential effects on switchgrass grown for biomass.
  Prasifka JR, Bradshaw JD, Lee ST, Gray ME.J Econ Entomol. 2011 Oct;104(5):1561-7.
• 5. Development of a rapid HPLC-UV method for simultaneous quantification of protodioscin and rutin in white and green asparagus spears.
  Lee EJ, Yoo KS, Patil BS.J Food Sci. 2010 Nov-Dec;75(9):C703-9. doi: 10.1111/j.1750-3841.2010.01824.x. Epub 2010 Oct 7.
• 6. Differential activity of multiple saponins against omnivorous insects with varying feeding preferences.
  Dowd PF, Berhow MA, Johnson ET.J Chem Ecol. 2011 May;37(5):443-9. doi: 10.1007/s10886-011-9950-3. Epub 2011 Apr 19.
• 7. [Determination by high performance chromatography, steroid saponins in a biologically active food supplements containing the extract of Tribulus terrestris].
  Kozlova OI, Perederiaev OI, Ramenskaia GV.Vopr Pitan. 2011;80(6):67-71. Russian.
• 8. Qualitative and quantitative determination of major saponins in Paris and Trillium by HPLC-ELSD and HPLC-MS/MS.
  Man S, Gao W, Zhang Y, Wang J, Zhao W, Huang L, Liu C.J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Nov 1;878(29):2943-8. doi: 10.1016/j.jchromb.2010.08.033. Epub 2010 Oct 1.
• 9. [Effect and mechanism of methyl protodioscin in protecting cardiomyocytes against anoxia/reoxygenation injury].
  Ning Z, Li YK, Zhou Y.Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010 Apr;30(4):407-9. Chinese.
• 10. Anti-thrombotic activity and chemical characterization of steroidal saponins from Dioscorea zingiberensis C.H. Wright.
  Li H, Huang W, Wen Y, Gong G, Zhao Q, Yu G.Fitoterapia. 2010 Dec;81(8):1147-56. doi: 10.1016/j.fitote.2010.07.016. Epub 2010 Jul 23.
• 11. The effect of fenugreek on the gene expression of arachidonic acid metabolizing enzymes.
  Varjas T, Nowrasteh G, Budán F, Horváth G, Cseh J, Gyöngyi Z, Makai S, Ember I.Phytother Res. 2011 Feb;25(2):221-7. doi: 10.1002/ptr.3231.
• 12. Ligand fishing from Dioscorea nipponica extract using human serum albumin functionalized magnetic nanoparticles.
  Qinga LS, Xue Y, Zheng Y, Xiong J, Liao X, Ding LS, Li BG, Liu YM.J Chromatogr A. 2010 Jul 9;1217(28):4663-8. doi: 10.1016/j.chroma.2010.05.009.
• 13. Antihyperlipidemic effect of protodioscin, an active ingredient isolated from the rhizomes of Dioscorea nipponica.
  Wang T, Choi RC, Li J, Li J, Bi CW, Zang L, Liu Z, Dong TT, Bi K, Tsim KW.Planta Med. 2010 Oct;76(15):1642-6. doi: 10.1055/s-0030-1249960. Epub 2010 May 27.
• 14. Pharmacokinetics of methyl protodioscin in rats.
  Cao X, Yao Z, Shao M, Chen H, Ye W, Yao X.Pharmazie. 2010 May;65(5):359-62.
• 15. [Effects of methyl protodioscin on [Ca2+]i and ATPase activity in cardiomyocytes and analysis of mechanisms].
  Ning Z, Li Y, Zhang R.Zhongguo Zhong Yao Za Zhi. 2010 Jan;35(1):80-3. Chinese.
• 16. A new spirostanol glycoside from fruits of Solanum indicum L.
  El-Aasr M, Miyashita H, Ikeda T, Lee JH, Yoshimitsu H, Nohara T, Murakami K.Chem Pharm Bull (Tokyo). 2009 Jul;57(7):747-8.
• 17. Steroidal saponins from Smilax excelsa rhizomes.
  Ivanova A, Mikhova B, Klaiber I, Dinchev D, Kostova I.Nat Prod Res. 2009;23(10):916-24. doi: 10.1080/14786410802624827.
• 18. [Determination of plasma protein binding rate of methyl protodioscin with ultrafiltration].
  Yao ZH, Cao XZ, Shao M, Pan YM, Ye WC, Yao XS.Zhongguo Zhong Yao Za Zhi. 2008 Jun;33(11):1291-4. Chinese.
• 19. New thinking in the development of novel derivatization reagents for liquid chromatography-mass spectrometric detection.
  Srinivas NR.Biomed Chromatogr. 2009 Jan;23(1):107-8. doi: 10.1002/bmc.1089. No abstract available.
• 20. Pregnane glycosides and steroid saponins from Smilax bockii Warb. and their NGF-potentiating activity.
  Xu J, Li X, Zhao CC, Wang Y.Nat Prod Res. 2008;22(10):884-9. doi: 10.1080/14786410701642557.

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