Botanical Ingredient

Pterostilbene Safety Tips

Handling of Pterostilbene should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Suppression of Nitric Oxide Production and Cardiovascular Risk Factors in Healthy Seniors and Hypercholesterolemic Subjects by a Combination of Polyphenols and Vitamins.
  Qureshi AA, Khan DA, Mahjabeen W, Papasian CJ, Qureshi N.J Clin Exp Cardiolog. 2012 Jun 7;S5:8.
• 2. Involvement of caspase-3 in stilbene derivatives induced apoptosis of human neutrophils in vitro.
  Pere?ko T, Drábiková K, Nosá? R, Harmatha J, Jan?inová V.Interdiscip Toxicol. 2012 Jun;5(2):76-80. doi: 10.2478/v10102-012-0013-6.
• 3. Effect of stilbene derivative on superoxide generation and enzyme release from human neutrophils in vitro.
  Ma?i?ková T, Pe?ivová J, Harmatha J, Sviteková K, Nosá? R.Interdiscip Toxicol. 2012 Jun;5(2):71-5. doi: 10.2478/v10102-012-0012-7.
• 4. Polyphenol derivatives – potential regulators of neutrophil activity.
  Drábiková K, Pere?ko T, Nosá? R, Harmatha J, Smidrkal J, Jan?inová V.Interdiscip Toxicol. 2012 Jun;5(2):65-70. doi: 10.2478/v10102-012-0011-8.
• 5. Decreased activity and accelerated apoptosis of neutrophils in the presence of natural polyphenols.
  Jan?inová V, Pere?ko T, Harmatha J, Nosá? R, Drábiková K.Interdiscip Toxicol. 2012 Jun;5(2):59-64. doi: 10.2478/v10102-012-0010-9.
• 6. Chemopreventive Effects of Pterostilbene on Urethane-Induced Lung Carcinogenesis in Mice via the Inhibition of EGFR-Mediated Pathways and the Induction of Apoptosis and Autophagy.
  Chen RJ, Tsai SJ, Ho CT, Pan MH, Ho YS, Wu CH, Wang YJ.J Agric Food Chem. 2012 Nov 21;60(46):11533-41. doi: 10.1021/jf302778a. Epub 2012 Nov 7.
• 7. Pterostilbene-induced tumor cytotoxicity: a lysosomal membrane permeabilization-dependent mechanism.
  Mena S, Rodríguez ML, Ponsoda X, Estrela JM, Jäättela M, Ortega AL.PLoS One. 2012;7(9):e44524. doi: 10.1371/journal.pone.0044524. Epub 2012 Sep 5.
• 8. Pterostilbene ameliorates tumor necrosis factor alpha-induced pancreatitis in vitro.
  McCormack D, McDonald D, McFadden D.J Surg Res. 2012 Nov;178(1):28-32. doi: 10.1016/j.jss.2012.08.004. Epub 2012 Aug 23.
• 9. Determination of hydroxylated stilbenes in wine by dispersive liquid-liquid microextraction followed by gas chromatography mass spectrometry.
  Rodríguez-Cabo T, Rodríguez I, Cela R.J Chromatogr A. 2012 Oct 5;1258:21-9. doi: 10.1016/j.chroma.2012.08.037. Epub 2012 Aug 17.
• 10. Pterostilbene, a natural small-molecular compound, promotes cytoprotective macroautophagy in vascular endothelial cells.
  Zhang L, Cui L, Zhou G, Jing H, Guo Y, Sun W.J Nutr Biochem. 2012 Aug 13. [Epub ahead of print]
• 11. Effect of polyphenols on enniatins-induced cytotoxic effects in mammalian cells.
  Lombardi G, Prosperini A, Font G, Ruiz MJ.Toxicol Mech Methods. 2012 Nov;22(9):687-95. doi: 10.3109/15376516.2012.717120.
• 12. Antihyperuricemic and nephroprotective effects of resveratrol and its analogues in hyperuricemic mice.
  Shi YW, Wang CP, Liu L, Liu YL, Wang X, Hong Y, Li Z, Kong LD.Mol Nutr Food Res. 2012 Sep;56(9):1433-44. doi: 10.1002/mnfr.201100828. Epub 2012 Aug 3.
• 13. Pterostilbene, a natural analogue of resveratrol, potently inhibits 7,12-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse skin carcinogenesis.
  Tsai ML, Lai CS, Chang YH, Chen WJ, Ho CT, Pan MH.Food Funct. 2012 Nov;3(11):1185-94. doi: 10.1039/c2fo30105a.
• 14. [Simultaneous determination of five active components in resina draconis and its extract by HPLC].
  Li Y, Xiao W, Qin J, Guo Y, Zhu Q.Zhongguo Zhong Yao Za Zhi. 2012 Apr;37(7):929-33. Chinese.
• 15. Calcofluor white combination antifungal treatments for Trichophyton rubrum and Candida albicans.
  Kingsbury JM, Heitman J, Pinnell SR.PLoS One. 2012;7(7):e39405. doi: 10.1371/journal.pone.0039405. Epub 2012 Jul 6.
• 16. Inhibition of nitric oxide and inflammatory cytokines in LPS-stimulated murine macrophages by resveratrol, a potent proteasome inhibitor.
  Qureshi AA, Guan XQ, Reis JC, Papasian CJ, Jabre S, Morrison DC, Qureshi N.Lipids Health Dis. 2012 Jul 10;11:76. doi: 10.1186/1476-511X-11-76.
• 17. Activation of AMPK by pterostilbene suppresses lipogenesis and cell-cycle progression in p53 positive and negative human prostate cancer cells.
  Lin VC, Tsai YC, Lin JN, Fan LL, Pan MH, Ho CT, Wu JY, Way TD.J Agric Food Chem. 2012 Jun 27;60(25):6399-407. doi: 10.1021/jf301499e. Epub 2012 Jun 19.
• 18. Comparison of conventional and non conventional methods of extraction of heartwood of Pterocarpus marsupium Roxb.
  Devgun M, Nanda A, Ansari SH.Acta Pol Pharm. 2012 May-Jun;69(3):475-85.
• 19. Inhibitory effects of (-)-epigallocatechin-3-gallate and pterostilbene on pancreatic cancer growth in vitro.
  Kostin SF, McDonald DE, McFadden DW.J Surg Res. 2012 Oct;177(2):255-62. doi: 10.1016/j.jss.2012.04.023. Epub 2012 May 3.
• 20. Pterostilbene induces mitochondrially derived apoptosis in breast cancer cells in vitro.
  Moon D, McCormack D, McDonald D, McFadden D.J Surg Res. 2012 Apr 29. [Epub ahead of print]

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