Botanical Ingredient

Salvianolic Acid B Safety Tips

Handling of Salvianolic Acid B should only be performed by personnel trained and familiar with the handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Salvianolic Acid B Attenuates Rat Hepatic Fibrosis via Downregulating Angiotensin II Signaling.
  Li S, Wang L, Yan X, Wang Q, Tao Y, Li J, Peng Y, Liu P, Liu C.Evid Based Complement Alternat Med. 2012;2012:160726. doi: 10.1155/2012/160726. Epub 2012 Nov 12.
• 2. Competitive inhibition of human organic anion transporters 1 (SLC22A6), 3 (SLC22A8), and 4 (SLC22A11) by major components of the medicinal herb Salvia miltiorrhiza (Danshen).
  Wang L, Sweet DH.Drug Metab Pharmacokinet. 2012 Dec 11. [Epub ahead of print]
• 3. Cardioprotective effect of salvianolic acid B against arsenic trioxide-induced injury in cardiac H9c2 cells via the PI3K/Akt signal pathway.
  Wang M, Sun GB, Sun X, Wang HW, Meng XB, Qin M, Sun J, Luo Y, Sun XB.Toxicol Lett. 2012 Nov 30. doi:pii: S0378-4274(12)01403-8.  10.1016/j.toxlet.2012.11.023. [Epub ahead of print]
• 4. Salvianolic acid B inhibits the amyloid formation of human islet amyloid polypeptide and protects pancreatic beta-cells against cytotoxicity.
  Cheng B, Gong H, Li X, Sun Y, Chen H, Zhang X, Wu Q, Zheng L, Huang K.Proteins. 2012 Nov 23. doi: 10.1002/prot.24216. [Epub ahead of print]
• 5. [Hydrogen peroxide is involved in the signal transduction of salicylic acid-induced salvianolic acid B biosynthesis in Salvia miltiorrhiza cell cultures].
  Chen H, Liu L, Dong J, Xia G.Sheng Wu Gong Cheng Xue Bao. 2012 Jul;28(7):834-46. Chinese.
• 6. [Effects of different light quality on growth, active ingredients and enzymes activitiesof Salvia miltiorrhiza].
  Liang Z, Li Q, Xu W.Zhongguo Zhong Yao Za Zhi. 2012 Jul;37(14):2055-60. Chinese.
• 7. Salvianolic Acid B reducing portal hypertension depends on macrophages in isolated portal perfused rat livers with chronic hepatitis.
  Zhao X, Jia H, Yang S, Liu Y, Deng B, Xu X, Zhang T, Zhou H, Zu C, Yin H, Li T, Song Y, Wang Y, Li P, Zou Z, Cai D.Evid Based Complement Alternat Med. 2012;2012:786365. doi: 10.1155/2012/786365. Epub 2012 Oct 16.
• 8. Bioavailability and foam cells permeability enhancement of Salvianolic acid B pellets based on drug-phospholipids complex technique.
  Li J, Liu P, Liu JP, Yang JK, Zhang WL, Fan YQ, Kan SL, Cui Y, Zhang WJ.Eur J Pharm Biopharm. 2012 Oct 22. doi:pii: S0939-6411(12)00319-0.  10.1016/j.ejpb.2012.09.021. [Epub ahead of print]
• 9. Effects of salvianolic acid B on survival, self-renewal and neuronal differentiation of bone marrow-derived neural stem cells.
  Zhang N, Kang T, Xia Y, Wen Q, Zhang X, Li H, Hu Y, Hao H, Zhao D, Sun D, Yan Y, Zhang GX, Yang J.Eur J Pharmacol. 2012 Dec 15;697(1-3):32-9. doi: 10.1016/j.ejphar.2012.10.008. Epub 2012 Oct 18.
• 10. Salvianolic acid B possesses vasodilation potential through NO and its related signals in rabbit thoracic aortic rings.
  Shou Q, Pan Y, Xu X, Xu J, Wang D, Ling Y, Chen M.Eur J Pharmacol. 2012 Dec 15;697(1-3):81-7. doi: 10.1016/j.ejphar.2012.09.044. Epub 2012 Oct 7.
• 11. Inhibitory effects of salvianolic acid B on CCl(4)-induced hepatic fibrosis through regulating NF-κB/IκBα signaling.
  Wang R, Yu XY, Guo ZY, Wang YJ, Wu Y, Yuan YF.J Ethnopharmacol. 2012 Dec 18;144(3):592-8. doi: 10.1016/j.jep.2012.09.048. Epub 2012 Oct 3.
• 12. [Pharmacokinetics of Danshen multi-component osmotic pump tablets in Beagle dogs].
  Zhou L, Liu X, Zheng J, Wu Q, Du S.Zhongguo Zhong Yao Za Zhi. 2012 Jun;37(12):1761-4. Chinese.
• 13. [Method for discriminating key quality control indicators of concentrated solution before traditional Chinese medicine ethanol precipitation].
  Yan A, Gong X, Qu H.Zhongguo Zhong Yao Za Zhi. 2012 Jun;37(11):1558-63. Chinese.
• 14. Salvianolic acid B lowers portal pressure in cirrhotic rats and attenuates contraction of rat hepatic stellate cells by inhibiting RhoA signaling pathway.
  Xu H, Zhou Y, Lu C, Ping J, Xu LM.Lab Invest. 2012 Dec;92(12):1738-48. doi: 10.1038/labinvest.2012.113. Epub 2012 Sep 17.
• 15. Biotransformation of salvianolic acid B by Fusarium oxysporum f. sp. Cucumerinum and its two degradation routes.
  Kan S, Lin H, Li J, Shao L, Chen D.Nat Prod Commun. 2012 Jul;7(7):885-8.
• 16. Three-channel column-switching high-performance liquid chromatography with electrochemical detection for determining bioactive redox components in Salvia miltiorrhiza.
  Chen X, Kotani A, Hakamata H, Wang J, Du S, Kusu F.J Chromatogr A. 2012 Sep 21;1256:105-13. doi: 10.1016/j.chroma.2012.07.061. Epub 2012 Jul 27.
• 17. Inhibition of hypoxia and serum deprivation-induced apoptosis by salvianolic acid in rat mesenchymal stem cells.
  Cao W, Guo XW, Chen K, Xu RX, Zheng HZ, Wang J.J Tradit Chin Med. 2012 Jun;32(2):222-8.
• 18. Active Hydrophilic Components of the Medicinal Herb Salvia miltiorrhiza (Danshen) Potently Inhibit Organic Anion Transporters 1 (Slc22a6) and 3 (Slc22a8).
  Wang L, Sweet DH.Evid Based Complement Alternat Med. 2012;2012:872458. doi: 10.1155/2012/872458. Epub 2012 Jul 15.
• 19. [Study on preparation method of Yueanjian for treatmen of premenstrual syndrome].
  Li X, Gan Y, Zhang H, Qiao M, Hou Z, Guan Z, Liang M.Zhongguo Zhong Yao Za Zhi. 2012 Apr;37(7):925-8. Chinese.
• 20. Chemical conversions of salvianolic acid B by decoction in aqueous solution.
  Lee HJ, Cho JY, Moon JH.Fitoterapia. 2012 Oct;83(7):1196-204. doi: 10.1016/j.fitote.2012.06.015. Epub 2012 Jul 8.

Details