Botanical Ingredient

Sclareol Safety Tips

Handling of Sclareol should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Extracellular Localization of the Diterpene Sclareol in Clary Sage (Salvia sclarea L., Lamiaceae).
  Caissard JC, Olivier T, Delbecque C, Palle S, Garry PP, Audran A, Valot N, Moja S, Nicolé F, Magnard JL, Legrand S, Baudino S, Jullien F.PLoS One. 2012;7(10):e48253. doi: 10.1371/journal.pone.0048253. Epub 2012 Oct 25.
• 2. Bioactive constituents of Salvia chrysophylla Stapf.
  Culhao?lu B, Yapar G, Dirmenci T, Topçu G.Nat Prod Res. 2012 Nov 6. [Epub ahead of print]
• 3. Toward a biosynthetic route to sclareol and amber odorants.
  Schalk M, Pastore L, Mirata MA, Khim S, Schouwey M, Deguerry F, Pineda V, Rocci L, Daviet L.J Am Chem Soc. 2012 Nov 21;134(46):18900-3. doi: 10.1021/ja307404u. Epub 2012 Nov 7.
• 4. Enzymatic biotransformation of terpenes as bioactive agents.
  Sultana N, Saify ZS.J Enzyme Inhib Med Chem. 2012 Oct 9. [Epub ahead of print]
• 5. A diterpene synthase from the clary sage Salvia sclarea catalyzes the cyclization of geranylgeranyl diphosphate to (8R)-hydroxy-copalyl diphosphate.
  Günnewich N, Higashi Y, Feng X, Choi KB, Schmidt J, Kutchan TM.Phytochemistry. 2012 Sep 5. [Epub ahead of print]
• 6. Cancer cell spheroids as a model to evaluate chemotherapy protocols.
  Perche F, Torchilin VP.Cancer Biol Ther. 2012 Oct;13(12):1205-13. doi: 10.4161/cbt.21353. Epub 2012 Aug 15.
• 7. Discovery and functional characterization of two diterpene synthases for sclareol biosynthesis in Salvia sclarea (L.) and their relevance for perfume manufacture.
  Caniard A, Zerbe P, Legrand S, Cohade A, Valot N, Magnard JL, Bohlmann J, Legendre L.BMC Plant Biol. 2012 Jul 26;12:119. doi: 10.1186/1471-2229-12-119.
• 8. Identification of natural diterpenes that inhibit bacterial wilt disease in tobacco, tomato and Arabidopsis.
  Seo S, Gomi K, Kaku H, Abe H, Seto H, Nakatsu S, Neya M, Kobayashi M, Nakaho K, Ichinose Y, Mitsuhara I, Ohashi Y.Plant Cell Physiol. 2012 Aug;53(8):1432-44. doi: 10.1093/pcp/pcs085. Epub 2012 Jun 7.
• 9. Sclareol exhibits anti-inflammatory activity in both lipopolysaccharide-stimulated macrophages and the λ-carrageenan-induced paw edema model.
  Huang GJ, Pan CH, Wu CH.J Nat Prod. 2012 Jan 27;75(1):54-9. doi: 10.1021/np200512a. Epub 2012 Jan 17.
• 10. Antimicrobial evaluation of diterpenes from Copaifera langsdorffii oleoresin against periodontal anaerobic bacteria.
  Souza AB, de Souza MG, Moreira MA, Moreira MR, Furtado NA, Martins CH, Bastos JK, dos Santos RA, Heleno VC, Ambrosio SR, Veneziani RC.Molecules. 2011 Nov 18;16(11):9611-9. doi: 10.3390/molecules16119611.
• 11. First enantiospecific synthesis of marine sesquiterpene quinol akaol A.
  Alvarez-Manzaneda E, Chahboun R, Alvarez E, Fernández A, Alvarez-Manzaneda R, Haidour A, Ramos JM, Akhaouzan A.Chem Commun (Camb). 2012 Jan 14;48(4):606-8. doi: 10.1039/c1cc14608d. Epub 2011 Nov 9.
• 12. Four potato (Solanum tuberosum) ABCG transporters and their expression in response to abiotic factors and Phytophthora infestans infection.
  Ruocco M, Ambrosino P, Lanzuise S, Woo SL, Lorito M, Scala F.J Plant Physiol. 2011 Dec 15;168(18):2225-33. doi: 10.1016/j.jplph.2011.07.008. Epub 2011 Sep 9.
• 13. Synthesis of the scalarane sesterterpenoid 16-deacetoxy-12-epi-scalarafuranacetate.
  Chen XB, Yuan QJ, Wang J, Hua SK, Ren J, Zeng BB.J Org Chem. 2011 Sep 2;76(17):7216-21. doi: 10.1021/jo2008127. Epub 2011 Aug 9.
• 14. The labdane diterpene sclareol (labd-14-ene-8, 13-diol) induces apoptosis in human tumor cell lines and suppression of tumor growth in vivo via a p53-independent mechanism of action.
  Mahaira LG, Tsimplouli C, Sakellaridis N, Alevizopoulos K, Demetzos C, Han Z, Pantazis P, Dimas K.Eur J Pharmacol. 2011 Sep;666(1-3):173-82. doi: 10.1016/j.ejphar.2011.04.065. Epub 2011 May 20.
• 15. Isolation, chemical, and biotransformation routes of labdane-type diterpenes.
  Frija LM, Frade RF, Afonso CA.Chem Rev. 2011 Aug 10;111(8):4418-52. doi: 10.1021/cr100258k. Epub 2011 May 27. Review. No abstract available.
• 16. Chemical composition and antimicrobial activity of the essential oils from Cleome spinosa.
  McNeil MJ, Porter RB, Williams LA, Rainford L.Nat Prod Commun. 2010 Aug;5(8):1301-6.
• 17. Sclareol modulates the Treg intra-tumoral infiltrated cell and inhibits tumor growth in vivo.
  Noori S, Hassan ZM, Mohammadi M, Habibi Z, Sohrabi N, Bayanolhagh S.Cell Immunol. 2010;263(2):148-53. doi: 10.1016/j.cellimm.2010.02.009. Epub 2010 Mar 10.
• 18. Mitochondria-targeted liposomes improve the apoptotic and cytotoxic action of sclareol.
  Patel NR, Hatziantoniou S, Georgopoulos A, Demetzos C, Torchilin VP, Weissig V, D’Souza GG.J Liposome Res. 2010 Sep;20(3):244-9. doi: 10.3109/08982100903347931.
• 19. Hemisynthesis of two marine cheilanthane sesterterpenes from (-)-sclareol: first enantioselective synthesis of petrosaspongiolide R.
  Ferreiro-Mederos L, Lanners S, Henchiri H, Fekih A, Hanquet G.Nat Prod Res. 2009;23(3):256-63. doi: 10.1080/14786410801997075.
• 20. Fragrance material review on sclareol.
  Bhatia SP, McGinty D, Letizia CS, Api AM.Food Chem Toxicol. 2008 Nov;46 Suppl 11:S270-4. doi: 10.1016/j.fct.2008.06.074. Epub 2008 Jul 2. Review.

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