Botanical Ingredient

References

• 1. Hypoglycaemic and hypolipidaemic activities of sesamin from sesame meal and its ability to ameliorate insulin resistance in KK-Ay mice.
  Hong L, Yi W, Liangliang C, Juncheng H, Qin W, Xiaoxiang Z.J Sci Food Agric. 2012 Oct 26. doi: 10.1002/jsfa.5974. [Epub ahead of print]
• 2. Long-term intake of sesamin improves left ventricular remodelling in spontaneously hypertensive rats.
  Li WX, Kong X, Zhang JX, Yang JR.Food Funct. 2012 Dec 14. [Epub ahead of print]
• 3. Sesamin suppresses activation of microglia and p44/42 MAPK pathway, which confers neuroprotection in rat intracerebral hemorrhage.
  Ohnishi M, Monda A, Takemoto R, Matsuoka Y, Kitamura C, Ohashi K, Shibuya H, Inoue A.Neuroscience. 2012 Dec 7. doi:pii: S0306-4522(12)01173-6.  10.1016/j.neuroscience.2012.11.057. [Epub ahead of print]
• 4. Fish oil at low dietary levels enhances physiological activity of sesamin to increase hepatic fatty acid oxidation in rats.
  Ide T.J Clin Biochem Nutr. 2012 Nov;51(3):241-7. doi: 10.3164/jcbn.12-38. Epub 2012 Oct 31.
• 5. In vitro inhibition of 7-ethoxyresorufin-O-deethylase (EROD) and p-nitrophenol hydroxylase (PNPH) activities by sesamin in hepatic microsomes from two fish species.
  Wagner L, Zlabek V, Trattner S, Zamaratskaia G.Mol Biol Rep. 2013 Jan;40(1):457-62. doi: 10.1007/s11033-012-2080-3. Epub 2012 Oct 12.
• 6. The sesame lignan sesamin attenuates vascular dysfunction in streptozotocin diabetic rats: Involvement of nitric oxide and oxidative stress.
  Baluchnejadmojarad T, Roghani M, Jalali Nadoushan MR, Vaez Mahdavi MR, Kalalian-Moghaddam H, Roghani-Dehkordi F, Dariani S, Raoufi S.Eur J Pharmacol. 2012 Oct 11. doi:pii: S0014-2999(12)00805-9.  10.1016/j.ejphar.2012.09.031. [Epub ahead of print]
• 7. Mechanisms Mediating the Synergistic Anticancer Effects of Combined γ-Tocotrienol and Sesamin Treatment.
  Akl MR, Ayoub NM, Sylvester PW.Planta Med. 2012 Nov;78(16):1731-9. doi: 10.1055/s-0032-1315302. Epub 2012 Sep 17.
• 8. Two new alkylresorcinols from Homalomena wendlandii and their cytotoxic activity.
  Sánchez LA, Olmedo D, López-Pérez JL, Williams TD, Gupta MP.Nat Prod Commun. 2012 Aug;7(8):1043-6.
• 9. Quercetin and sesamin protect dopaminergic cells from MPP+-induced neuroinflammation in a microglial (N9)-neuronal (PC12) coculture system.
  Bournival J, Plouffe M, Renaud J, Provencher C, Martinoli MG.Oxid Med Cell Longev. 2012;2012:921941. doi: 10.1155/2012/921941. Epub 2012 Jul 3.
• 10. Tissue distribution and cytochrome P450 inhibition of sesaminol and its tetrahydrofuranoid metabolites.
  Jan KC, Chang YW, Hwang LS, Ho CT.J Agric Food Chem. 2012 Sep 5;60(35):8616-23. doi: 10.1021/jf302699f. Epub 2012 Aug 23.
• 11. Plasma and tissue concentrations of α-tocopherol and δ-tocopherol following high dose dietary supplementation in mice.
  Baxter LL, Marugan JJ, Xiao J, Incao A, McKew JC, Zheng W, Pavan WJ.Nutrients. 2012 Jun;4(6):467-90. doi: 10.3390/nu4060467. Epub 2012 Jun 6.
• 12. Prophylactic Sesame Oil Attenuates Sinusoidal Obstruction Syndrome by Inhibiting Matrix Metalloproteinase-9 and Oxidative Stress.
  Periasamy S, Yang SS, Chen SY, Chang CC, Liu MY.JPEN J Parenter Enteral Nutr. 2012 Jul 20. [Epub ahead of print]
• 13. Sesamin modulates gene expression without corresponding effects on fatty acids in Atlantic salmon (Salmo salar L.).
  Schiller Vestergren A, Wagner L, Pickova J, Rosenlund G, Kamal-Eldin A, Trattner S.Lipids. 2012 Sep;47(9):897-911. doi: 10.1007/s11745-012-3697-7. Epub 2012 Jul 13.
• 14. Combined effect of sesamin and α-lipoic acid on hepatic fatty acid metabolism in rats.
  Ide T, Azechi A, Kitade S, Kunimatsu Y, Suzuki N, Nakajima C.Eur J Nutr. 2012 Jun 30. [Epub ahead of print]
• 15. Comparison of metabolism of sesamin and episesamin by drug-metabolizing enzymes in human liver.
  Yasuda K, Ikushiro S, Wakayama S, Itoh T, Yamamoto K, Kamakura M, Munetsuna E, Ohta M, Sakaki T.Drug Metab Dispos. 2012 Oct;40(10):1917-26. doi: 10.1124/dmd.112.045906. Epub 2012 Jun 29.
• 16. Chondroprotective and anti-inflammatory effects of sesamin.
  Phitak T, Pothacharoen P, Settakorn J, Poompimol W, Caterson B, Kongtawelert P.Phytochemistry. 2012 Aug;80:77-88. doi: 10.1016/j.phytochem.2012.05.016. Epub 2012 Jun 14.
• 17. Identification of the metabolites of episesamin in rat bile and human liver microsomes.
  Tomimori N, Nakai M, Ono Y, Kitagawa Y, Kiso Y, Shibata H.Biol Pharm Bull. 2012;35(5):709-16.
• 18. Sesamin stimulates osteoblast differentiation through p38 and ERK1/2 MAPK signaling pathways.
  Wanachewin O, Boonmaleerat K, Pothacharoen P, Reutrakul V, Kongtawelert P.BMC Complement Altern Med. 2012 May 30;12:71. doi: 10.1186/1472-6882-12-71.
• 19. Sesamin: A Naturally Occurring Lignan Inhibits CYP3A4 by Antagonizing the Pregnane X Receptor Activation.
  Lim YP, Ma CY, Liu CL, Lin YH, Hu ML, Chen JJ, Hung DZ, Hsieh WT, Huang JD.Evid Based Complement Alternat Med. 2012;2012:242810. doi: 10.1155/2012/242810. Epub 2012 May 7.
• 20. Improvement of Liver Function in Humans Using a Mixture of Schisandra Fruit Extract and Sesamin.
  Chiu HF, Chen TY, Tzeng YT, Wang CK.Phytother Res. 2012 May 21. doi: 10.1002/ptr.4702. [Epub ahead of print]