Standard Herbal Extract

Siberian Ginseng Extract Safety Tips

Handling of Siberian Ginseng Extract should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Structural characterization and study of immunoenhancing properties of a glucan isolated from a hybrid mushroom of Pleurotus florida and Lentinula edodes.
  Maji PK, Sen IK, Behera B, Maiti TK, Mallick P, Sikdar SR, Islam SS.Carbohydr Res. 2012 Sep 1;358:110-5. doi: 10.1016/j.carres.2012.06.017. Epub 2012 Jul 5.
• 2. Direct cytotoxicity of Lentinula edodes mycelia extract on the human hepatocellular carcinoma cell line.
  Yukawa H, Ishikawa S, Kawanishi T, Tamesada M, Tomi H.Biol Pharm Bull. 2012;35(7):1014-21.
• 3. The anticaries effect of a food extract (shiitake) in a short-term clinical study.
  Lingström P, Zaura E, Hassan H, Buijs MJ, Hedelin P, Pratten J, Spratt D, Daglia M, Karbowiak A, Signoretto C, Rosema M, van der Weijden F, Wilson M.J Biomed Biotechnol. 2012;2012:217164. doi: 10.1155/2012/217164. Epub 2012 Feb 7.
• 4. A multiherbal formulation influencing immune response in vitro.
  Menghini L, Leporini L, Scanu N, Pintore G, Ferrante C, Recinella L, Orlando G, Vacca M, Brunetti L.Minerva Med. 2012 Feb;103(1):13-21.
• 5. Physicochemical properties and acute toxicity studies of a lectin from the saline extract of the fruiting bodies of the shiitake mushroom, Lentinula edodes (Berk).
  Eghianruwa Q, Odekanyin O, Kuku A.Int J Biochem Mol Biol. 2011;2(4):309-17. Epub 2011 Nov 10.
• 6. Efficacy of orally administered Lentinula edodes mycelia extract for advanced gastrointestinal cancer patients undergoing cancer chemotherapy: a pilot study.
  Okuno K, Uno K.Asian Pac J Cancer Prev. 2011;12(7):1671-4.
• 7. Oral ingestion of Lentinula edodes mycelia extract can restore the antitumor             T cell response of mice inoculated with colon-26 cells into the subserosal space             of the cecum.
  Tanaka K, Matsui Y, Ishikawa S, Kawanishi T, Harada M.Oncol Rep. 2012 Feb;27(2):325-32. doi: 10.3892/or.2011.1549. Epub 2011 Nov 11.
• 8. In vitro assessment of shiitake mushroom (Lentinula edodes) extract for its antigingivitis activity.
  Ciric L, Tymon A, Zaura E, Lingström P, Stauder M, Papetti A, Signoretto C, Pratten J, Wilson M, Spratt D.J Biomed Biotechnol. 2011;2011:507908. doi: 10.1155/2011/507908. Epub 2011 Sep 28.
• 9. The effects of fractions from shiitake mushroom on composition and cariogenicity of dental plaque microcosms in an in vitro caries model.
  Zaura E, Buijs MJ, Hoogenkamp MA, Ciric L, Papetti A, Signoretto C, Stauder M, Lingström P, Pratten J, Spratt DA, Wilson M.J Biomed Biotechnol. 2011;2011:135034. doi: 10.1155/2011/135034. Epub 2011 Sep 14.
• 10. Testing a low molecular mass fraction of a mushroom (Lentinus edodes) extract formulated as an oral rinse in a cohort of volunteers.
  Signoretto C, Burlacchini G, Marchi A, Grillenzoni M, Cavalleri G, Ciric L, Lingström P, Pezzati E, Daglia M, Zaura E, Pratten J, Spratt DA, Wilson M, Canepari P.J Biomed Biotechnol. 2011;2011:857987. doi: 10.1155/2011/857987. Epub 2011 Sep 8.
• 11. Low-molecular-weight lignin-rich fraction in the extract of cultured Lentinula edodes mycelia attenuates carbon tetrachloride-induced toxicity in primary cultures of rat hepatocytes.
  Yoshioka Y, Kojima H, Tamura A, Tsuji K, Tamesada M, Yagi K, Murakami N.J Nat Med. 2012 Jan;66(1):185-91. doi: 10.1007/s11418-011-0580-4. Epub 2011 Sep 9.
• 12. Protective effects of fractional extracts from Panellus serotinus on non-alcoholic fatty liver disease in obese, diabetic db/db mice.
  Inafuku M, Nagao K, Nomura S, Shirouchi B, Inoue N, Nagamori N, Nakayama H, Toda T, Yanagita T.Br J Nutr. 2012 Mar;107(5):639-46. doi: 10.1017/S0007114511003485. Epub 2011 Jul 26.
• 13. An evidence-based review of a Lentinula edodes mushroom extract as complementary therapy in the surgical oncology patient.
  Shah SK, Walker PA, Moore-Olufemi SD, Sundaresan A, Kulkarni AD, Andrassy RJ.JPEN J Parenter Enteral Nutr. 2011 Jul;35(4):449-58. doi: 10.1177/0148607110380684. Epub 2011 May 31. Review.
• 14. Efficacy and safety of orally administered Lentinula edodes mycelia extract for patients undergoing cancer chemotherapy: a pilot study.
  Yamaguchi Y, Miyahara E, Hihara J.Am J Chin Med. 2011;39(3):451-9.
• 15. Oral ingestion of Lentinula edodes mycelia extract inhibits B16 melanoma growth via mitigation of regulatory T cell-mediated immunosuppression.
  Tanaka K, Ishikawa S, Matsui Y, Tamesada M, Harashima N, Harada M.Cancer Sci. 2011 Mar;102(3):516-21. doi: 10.1111/j.1349-7006.2010.01841.x. Epub 2011 Jan 25.
• 16. A repeated dose 28-day oral toxicity study of extract from cultured Lentinula edodes mycelia in Wistar rats.
  Yoshioka Y, Tamesada M, Tomi H.J Toxicol Sci. 2010 Oct;35(5):785-91.
• 17. DNA microarray analysis of signaling pathway in macrophages stimulated by lignin-carbohydrate complex from lentinus edodes mycelia (LEM) extract.
  Kawano M, Thet MM, Makino T, Kushida T, Sakagami H.Anticancer Res. 2010 Jul;30(7):2567-76.
• 18. In vitro antioxidant activity and hepatoprotective effects of Lentinula edodes against paracetamol-induced hepatotoxicity.
  Sasidharan S, Aravindran S, Latha LY, Vijenthi R, Saravanan D, Amutha S.Molecules. 2010 Jun 23;15(6):4478-89. doi: 10.3390/molecules15064478.
• 19. Inhibition of degranulation and cytokine production in bone marrow-derived mast cells by hydrolyzed rice bran.
  Hoshino Y, Hirashima N, Nakanishi M, Furuno T.Inflamm Res. 2010 Aug;59(8):615-25. doi: 10.1007/s00011-010-0173-9. Epub 2010 Mar 5.
• 20. Structural analysis of glycogen-like polysaccharides having macrophage-activating activity in extracts of Lentinula edodes mycelia.
  Kojima H, Akaki J, Nakajima S, Kamei K, Tamesada M.J Nat Med. 2010 Jan;64(1):16-23. doi: 10.1007/s11418-009-0357-1. Epub 2009 Aug 27.

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