Botanical Ingredient

Sinomenine Safety Tips

Handling of Sinomenine should only be performed by personnel trained and familiar with the handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Analysis of active alkaloids in the Menispermaceae family by nonaqueous capillary electrophoresis-ion trap mass spectrometry.
  Chen Q, Zhang J, Zhang W, Chen Z.J Sep Sci. 2012 Dec 18. doi: 10.1002/jssc.201200678. [Epub ahead of print]
• 2. [Effects of sinomenine and methotrexate on fibroblast-like synoviocytes in rheumatoid arthritis].
  Sun Y, Ding CZ, Yao Y.Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 Aug;32(8):1107-11. Chinese.
• 3. Sinomenine hydrochloride inhibits human hepatocellular carcinoma cell             growth in vitro and in vivo: involvement of cell cycle arrest and apoptosis induction.
  Lu XL, Zeng J, Chen YL, He PM, Wen MX, Ren MD, Hu YN, Lu GF, He SΧ.Int J Oncol. 2013 Jan;42(1):229-38. doi: 10.3892/ijo.2012.1704. Epub 2012 Nov 16.
• 4. Probing the influences of urea on the interaction of sinomenine with human serum albumin by steady-state fluorescence.
  Li D, Hong D, Guo H, Chen J, Ji B.J Photochem Photobiol B. 2012 Dec 5;117:126-31. doi: 10.1016/j.jphotobiol.2012.09.007. Epub 2012 Oct 8.
• 5. Effect of sinomenine on vascular smooth muscle cell dedifferentiation and neointima formation after vascular injury in mice.
  Zhu L, Hao Y, Guan H, Cui C, Tian S, Yang D, Wang X, Zhang S, Wang L, Jiang H.Mol Cell Biochem. 2012 Oct 13. [Epub ahead of print]
• 6. Anti-inflammatory effect of sinomenine by inhibition of pro-inflammatory mediators in PMA plus A23187-stimulated HMC-1 Cells.
  Oh YC, Kang OH, Kim SB, Mun SH, Park CB, Kim YG, Kim YI, Lee YS, Han SH, Keum JH, Shin DW, Ma JY, Kwon DY.Eur Rev Med Pharmacol Sci. 2012 Sep;16(9):1184-91.
• 7. Effects of alkaloid sinomenine on levels of IFN-γ, IL-1β, TNF-α and IL-6 in a rat renal allograft model.
  Xiong L, Yang L.Immunotherapy. 2012 Aug;4(8):785-91. doi: 10.2217/imt.12.80.
• 8. Sinomenine hydrochloride enhancement of the inhibitory effects of anti-transferrin receptor antibody-dependent on the COX-2 pathway in human hepatoma cells.
  Hong Y, Yang J, Shen X, Zhu H, Sun X, Wen X, Bian J, Hu H, Yuan L, Tao J, Lei P, Shen G.Cancer Immunol Immunother. 2012 Sep 2. [Epub ahead of print]
• 9. Gastrodin inhibits cell proliferation in vascular smooth muscle cells             and attenuates neointima formation in vivo.
  Zhu L, Guan H, Cui C, Tian S, Yang D, Wang X, Zhang S, Wang L, Jiang H.Int J Mol Med. 2012 Nov;30(5):1034-40. doi: 10.3892/ijmm.2012.1100. Epub 2012 Aug 20.
• 10. Design, synthesis and molecular docking studies of sinomenine derivatives.
  Chai X, Guan Z, Yu S, Zhao Q, Hu H, Zou Y, Tao X, Wu Q.Bioorg Med Chem Lett. 2012 Sep 15;22(18):5849-52. doi: 10.1016/j.bmcl.2012.07.087. Epub 2012 Aug 1.
• 11. Therapeutic effect of an injectable sustained-release sinomenine hydrochloride and sodium hyaluronate compound in a rabbit model of osteoarthritis.
  Liu WG, Ling PX, Lin XK, Chen JY, Wang SJ, Li P, Wu XJ, Zhao DM, Liu SH.Chin Med J (Engl). 2012 Jul;125(14):2543-7.
• 12. Sinomenine inhibits proliferation of SGC-7901 gastric adenocarcinoma cells via suppression of cyclooxygenase-2 expression.
  Lv Y, Li C, Li S, Hao Z.Oncol Lett. 2011 Jul;2(4):741-745. Epub 2011 May 13.
• 13. Sinomenine can prolong high-risk corneal graft survival in a rat model.
  Wang Y, Ma D, Jie Y, Wu Y, Pan Z.Immunotherapy. 2012 Jun;4(6):581-6. doi: 10.2217/imt.12.45.
• 14. Sinomenium acutum: a review of chemistry, pharmacology, pharmacokinetics, and clinical use.
  Zhao XX, Peng C, Zhang H, Qin LP.Pharm Biol. 2012 Aug;50(8):1053-61. doi: 10.3109/13880209.2012.656847. Review.
• 15. Tissue-specific metabolite profiling of alkaloids in Sinomenii Caulis using laser microdissection and liquid chromatography-quadrupole/time of flight-mass spectrometry.
  Yi L, Liang ZT, Peng Y, Yao X, Chen HB, Zhao ZZ.J Chromatogr A. 2012 Jul 27;1248:93-103. doi: 10.1016/j.chroma.2012.05.058. Epub 2012 May 24.
• 16. Protective effects of sinomenine against doxorubicin-induced nephrosis in rats.
  Zhang J, Hu R, Xia ZK, Ren XG, Zhang LW, Liang YH, Liu GL.J Asian Nat Prod Res. 2012;14(7):678-87. doi: 10.1080/10286020.2012.685070. Epub 2012 May 15.
• 17. Activation of PI3K/Akt and ERK signaling pathways antagonized sinomenine-induced             lung cancer cell apoptosis.
  Zhou L, Luan H, Liu Q, Jiang T, Liang H, Dong X, Shang H.Mol Med Report. 2012 May;5(5):1256-60. doi: 10.3892/mmr.2012.798. Epub 2012 Feb 20.
• 18. Determination of sinomenine sustained-release capsules in healthy Chinese volunteers by liquid chromatography-tandem mass spectrometry.
  Su MX, Song M, Sun DZ, Zhao H, Gu X, Zhu L, Zhan XL, Xu ZN, Wen AD, Hang TJ.J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Mar 15;889-890:39-43. doi: 10.1016/j.jchromb.2012.01.027. Epub 2012 Feb 2.
• 19. Synthesis and biological evaluation of novel sinomenine derivatives as anti-inflammatory agents.
  Teng P, Liu HL, Zhang L, Feng LL, Huai Y, Deng ZS, Sun Y, Xu Q, Li JX.Eur J Med Chem. 2012 Apr;50:63-74. doi: 10.1016/j.ejmech.2012.01.036. Epub 2012 Jan 28.
• 20. Effect of the Japanese herbal medicine, Boiogito, on the osteoarthritis of the knee with joint effusion.
  Majima T, Inoue M, Kasahara Y, Onodera T, Takahashi D, Minami A.Sports Med Arthrosc Rehabil Ther Technol. 2012 Jan 10;4:3. doi: 10.1186/1758-2555-4-3.

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